Transplacental transmission of mRNA injections confirmed: does this evidence by Hanna and colleagues support their proposition as a promising prenatal gene therapy?

Опубликована: Авг. 25, 2024

A recent study by Hanna and collaborators assessed the presence of COVID-19 mRNA productsin placenta umbilical cord blood following maternal “vaccination” during human pregnancy.Their analysis 2 pregnant women revealed that genetic injections was detected inboth placentas. Spike protein expression confirmed in one them. Furthermore,the engineered mother, wherethose samples were available for analysis. They also found integrity injected varied across samples, but overall, a substantial or even overwhelming majority consisted non-integrous species. The authors provide several theoretical reasons they believe explain their experiential observations. Based on results shifting aim, indicate benefits suggest related gene therapies, particularly mRNA-based treatments, may have great promise as prenatal therapy. This article analyses findings interpretations identifies gaps inconsistencies explanations. It provides short synopsis update known problems with outlines major pitfalls unknowns underlying thepromised intended therapy applications.

Язык: Английский

Autoantibodies Targeting G-Protein-Coupled Receptors and RAS-Related Molecules in Post-Acute COVID Vaccination Syndrome: A Retrospective Case Series Study

Biomedicines, Год журнала: 2024, Номер 12(12), С. 2852 - 2852

Опубликована: Дек. 15, 2024

Background/Objectives: While post-acute COVID-19 syndrome is well known and extensively studied, the COVID vaccination (PACVS) a more recent nosological entity that poorly defined at immunopathological level, although it shares many symptoms with sequelae of viral infections. Methods: This single-center retrospective study reports case series 17 subjects vaccinated mRNA or adenoviral vector vaccines who were healthy before had never been infected SARS-CoV-2 but presented similar to PACVS for median time 20 months (min 4, max 32). The medical records all patients referred our outpatient clinic over one-year period retrospectively analyzed. Results: In this group, serological tests showed that, in addition positivity anti-spike protein antibodies, high percentage positive antibodies against G protein-coupled receptors molecules involved response SARS-CoV-2. panel 16 autoantibodies tested, few positively associated some reported by patients: anti-ATR1 lymphadenopathy and/or tonsillitis; anti-ACE2 skin such as ecchymosis, oedema, rash; anti-MAS1 widespread burning sensation; anti-STAB1 oedema rash. Anti-ADRA2A negatively memory loss mental fog. ACE2 correlated serum levels anti-S supporting hypothesis an anti-idiotype mechanism immunopathogenesis PACVS. Conclusions: exploratory analysis suggests directed ACE2, probably also MAS1 STAB1, may serve biomarkers

Язык: Английский