Predominant pro-inflammatory environment in mid-gestation pregnant women with history of recurrent pregnancy loss: a South Indian study DOI Creative Commons
Rashmi Bhuwalka, Sufaya Jameel,

Fazul Rahaman

и другие.

Exploration of Immunology, Год журнала: 2025, Номер 5

Опубликована: Апрель 8, 2025

Aim: To assess circulating levels of tumor necrosis factor-alpha (TNF-α) and transforming growth factor-beta (TGF-β) in mid-gestation pregnant women from South India, with (RPL) without history recurrent pregnancy loss (non-RPL) its correlation neutrophil to lymphocyte ratio (NLR). Methods: Blood samples were collected 400 attending government maternity hospital, Hyderabad, subjected enzyme linked immunosorbent assay (ELISA) for cytokines. NLR was calculated absolute cell counts obtained hospital records. Mann-Whitney U Spearman r conducted as data followed non-normal distribution. Results: We found significantly decreased level TGF-β elevated TNF-α, TNF-α/TGF-β (P < 0.0001), = 0.0007) patients over controls. Receiver operating curve characteristics (area under curve: 0.96) superior individual cytokines when compared the control group. A negative noted between RPL group 0.0041). Conclusions: Our results are indicative predominant pro-inflammatory environment during contrary anti-inflammatory milieu This is first study that attempted connect cellular RPL. The affordability track inflammation promised by inverse TGF-β. However, further longitudinal studies warranted spanning all stages gestation normal establish our observations. limitations include other factors drive status like emotional dysregulation associated chronic unexplored.

Язык: Английский

Decoding immune tolerance in infertility: Exploring immune pathways and non-coding RNAs as pioneering biomarkers and therapeutic targets DOI
Harikumar Pallathadka,

Abdulrahman Qais Khaleel,

Ahmed Hjazi

и другие.

Human Immunology, Год журнала: 2025, Номер 86(3), С. 111264 - 111264

Опубликована: Фев. 20, 2025

Язык: Английский

Процитировано

0
Functions of the Fusogenic and Non-fusogenic Activities of Syncytin-1 in Human Physiological and Pathological Processes DOI

Yuling Chen,

Ya Xu, Yu Zhang

и другие.

Biochemical and Biophysical Research Communications, Год журнала: 2025, Номер unknown, С. 151746 - 151746

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Predominant pro-inflammatory environment in mid-gestation pregnant women with history of recurrent pregnancy loss: a South Indian study DOI Creative Commons
Rashmi Bhuwalka, Sufaya Jameel,

Fazul Rahaman

и другие.

Exploration of Immunology, Год журнала: 2025, Номер 5

Опубликована: Апрель 8, 2025

Aim: To assess circulating levels of tumor necrosis factor-alpha (TNF-α) and transforming growth factor-beta (TGF-β) in mid-gestation pregnant women from South India, with (RPL) without history recurrent pregnancy loss (non-RPL) its correlation neutrophil to lymphocyte ratio (NLR). Methods: Blood samples were collected 400 attending government maternity hospital, Hyderabad, subjected enzyme linked immunosorbent assay (ELISA) for cytokines. NLR was calculated absolute cell counts obtained hospital records. Mann-Whitney U Spearman r conducted as data followed non-normal distribution. Results: We found significantly decreased level TGF-β elevated TNF-α, TNF-α/TGF-β (P < 0.0001), = 0.0007) patients over controls. Receiver operating curve characteristics (area under curve: 0.96) superior individual cytokines when compared the control group. A negative noted between RPL group 0.0041). Conclusions: Our results are indicative predominant pro-inflammatory environment during contrary anti-inflammatory milieu This is first study that attempted connect cellular RPL. The affordability track inflammation promised by inverse TGF-β. However, further longitudinal studies warranted spanning all stages gestation normal establish our observations. limitations include other factors drive status like emotional dysregulation associated chronic unexplored.

Язык: Английский

Процитировано

0