Advancements in MRSA treatment: the role of berberine in enhancing antibiotic therapy DOI Creative Commons

Fangfang Zhou,

Xuemei Gu,

Wei Wang

и другие.

BMC Microbiology, Год журнала: 2024, Номер 24(1)

Опубликована: Дек. 27, 2024

Язык: Английский

The Imidazolium Ionic Liquids Toxicity is Due to Their Effect on the Plasma Membrane DOI
С. С. Соколов,

Ekaterina A. Smirnova,

Tatyana I. Rokitskaya

и другие.

Biochemistry (Moscow), Год журнала: 2024, Номер 89(3), С. 451 - 461

Опубликована: Март 1, 2024

Язык: Английский

Процитировано

1
Triphenylphosphonium Analogs of Short Peptide Related to Bactenecin 7 and Oncocin 112 as Antimicrobial Agents DOI Creative Commons
Andrey G. Tereshchenkov, Zimfira Z. Khairullina, Inna A. Volynkina

и другие.

Pharmaceutics, Год журнала: 2024, Номер 16(1), С. 148 - 148

Опубликована: Янв. 22, 2024

Antimicrobial peptides (AMPs) have recently attracted attention as promising antibacterial agents capable of acting against resistant bacterial strains. In this work, an approach was applied, consisting the conjugation a peptide related to sequences bactenecin 7 (Bac7) and oncocin (Onc112) with alkyl(triphenyl)phosphonium (alkyl-TPP) fragment in order improve properties AMP introduce new ones, expand spectrum antimicrobial activity, reduce inhibitory effect on eukaryotic translation process. Triphenylphosphonium (TPP) derivatives decapeptide RRIRPRPPYL were synthesized. It comprehensively studied how modification affected compounds. shown that while reduction Bac7 length 10 a.a. residues dramatically decreased affinity ribosomes, alkyl-TPP moieties led increase affinity. New analogs structures combined Onc112—Bac(1–10, R/Y)—and TPP attached C-terminal amino acid residue via alkylamide linkers, inhibited vitro found be more selective inhibitors compared than Onc112 Bac7. The suppressed growth both Gram-negative bacteria, similar Bac7, Gram-positive derivatives, also acted some laboratory Bac(1–10, R/Y)-C2-TPP, containing short linker between TPP, transferred into E. coli cells SbmA transporter protein. R/Y) either decylamide or ethylamide caused B. subtilis membrane depolarization, alkyl-TPP. R/Y)-C2-TPP analog proven non-toxic for mammalian using MTT test.

Язык: Английский

Процитировано

0
Synthesis of Triphenylphosphonium-Linked Derivative of 3,5-Ditert-butyl-4-hydroxybenzylidene-malononitrile (SF6847) via Knoevenagel Reaction Yields an Effective Mitochondria-Targeted Protonophoric Uncoupler DOI Creative Commons
Roman S. Kirsanov,

Ljudmila S. Khailova,

Tatyana I. Rokitskaya

и другие.

ACS Omega, Год журнала: 2024, Номер 9(10), С. 11551 - 11561

Опубликована: Фев. 29, 2024

Mitochondrial uncouplers are actively sought as potential therapeutics. Here, we report the first successful synthesis of mitochondria-targeted derivatives highly potent uncoupler 3,5-ditert-butyl-4-hydroxybenzylidene-malononitrile (SF6847), bearing a cationic alkyl(triphenyl)phosphonium (TPP) group. As key step synthesis, used condensation ketophenol with malononitrile via Knoevenagel reaction. SF-C5-TPP pentamethylene linker between SF6847 and TPP, stimulating respiration collapsing membrane rat liver mitochondria at submicromolar concentrations, proved to be most effective series. showed pronounced protonophoric activity on model planar bilayer lipid membrane. Importantly, exhibited rather low toxicity in fibroblast cell culture, causing mitochondrial depolarization cells concentrations that only slightly affected viability. was more decreasing culture than SF6847, contrast case isolated mitochondria. Like other zwitterionic uncouplers, inhibited growth Bacillus subtilis micromolar concentration range.

Язык: Английский

Процитировано

0
KOH-treated tire pyrolyzed carbon as green and easily available adsorbent for Bisphenol A and Methylene blue adsorption DOI

Shiva Deepti Rangu,

Harsha S. Rangappa,

Phyu Phyu Mon

и другие.

Environmental Science and Pollution Research, Год журнала: 2024, Номер unknown

Опубликована: Авг. 20, 2024

Язык: Английский

Процитировано

0
The Imidazolium Ionic Liquids Toxicity Is Due to Their Effect on the Plasma Membrane DOI
С. С. Соколов, Е. А. Смирнова, Tatyana I. Rokitskaya

и другие.

Биохимия, Год журнала: 2024, Номер 89(3), С. 406 - 417

Опубликована: Сен. 14, 2024

Ionic liquids (ILs) are organic salts with a low melting point, which is due to the fact that alkyl side chains chemically bonded ion hinder crystallization of ILs. The point ILs has led their widespread use as relatively harmless solvents. However, have toxic properties, mechanism largely unknown, so identifying cellular targets practical importance. In our work, we showed imidazolium not able penetrate model membranes without damaging them. We also found inactivation multidrug resistance (MDR) pumps in yeast cells does increase sensitivity latter indicates target toxicity cytoplasm. Thus, data suggest disruption plasma membrane barrier function main cause concentrations supplementation restores growth kinetically blocked glycolysis. Our indicate IL-induced minor may, some cases, be beneficial for cells.

Язык: Английский

Процитировано

0
Inhibitory effects of berberine on fungal growth, biofilm formation, virulence, and drug resistance as an antifungal drug and adjuvant with prospects for future applications DOI

Junping Ding,

Yan Zhong, Liang Peng

и другие.

World Journal of Microbiology and Biotechnology, Год журнала: 2024, Номер 41(1)

Опубликована: Дек. 18, 2024

Язык: Английский

Процитировано

0
Advancements in MRSA treatment: the role of berberine in enhancing antibiotic therapy DOI Creative Commons

Fangfang Zhou,

Xuemei Gu,

Wei Wang

и другие.

BMC Microbiology, Год журнала: 2024, Номер 24(1)

Опубликована: Дек. 27, 2024

Язык: Английский

Процитировано

0