Salivary biomarkers for the molecular diagnosis of dementia with Lewy bodies DOI Creative Commons
Fabrizia D’Antonio, Giorgio Vivacqua,

Marco Serrentino

и другие.

Journal of Alzheimer s Disease, Год журнала: 2025, Номер unknown

Опубликована: Март 14, 2025

Background Despite dementia with Lewy bodies (DLB) being the second most common form of neurodegenerative dementia, more than 80% DLB cases are initially misdiagnosed. Alpha-synuclein (a-syn) and tau species have been detected in peripheral tissues biological fluids patients among different fluids, saliva represent an easely accessible non-invasive source for biomarker detection. Objective This study aimed to investigate salivary a-syn as molecular disease biomarkers, assessing their potential diagnosis differential on respect Alzheimer's (AD) Parkinson's (PD). Methods We measured total oligomeric a-syn, total-tau, S199-phosphorylated-tau (pS199-tau) 21 DLB, 20 AD, PD patients, healthy subjects (HS) using quantitative enzyme-linked immunosorbent assay (ELISA) analyses. Results Salivary was not significantly changed between groups, whereas all pathological groups had a higher concentration HS. total-tau HS, concentrations did differ patients’ groups. Conversely, levels pS199-tau AD HS patients. Both correlation matrix principal component analysis showed that core clinical features were related pathology, while cognitive decline associated both Receiver operating characteristic reported high diagnostic accuracy oligomers pS199-tau, adequate PD. optimal Conclusions These findings provide preliminary evidence might be promising identifying is limited AD.

Язык: Английский

Salivary biomarkers for the molecular diagnosis of dementia with Lewy bodies DOI Creative Commons
Fabrizia D’Antonio, Giorgio Vivacqua,

Marco Serrentino

и другие.

Journal of Alzheimer s Disease, Год журнала: 2025, Номер unknown

Опубликована: Март 14, 2025

Background Despite dementia with Lewy bodies (DLB) being the second most common form of neurodegenerative dementia, more than 80% DLB cases are initially misdiagnosed. Alpha-synuclein (a-syn) and tau species have been detected in peripheral tissues biological fluids patients among different fluids, saliva represent an easely accessible non-invasive source for biomarker detection. Objective This study aimed to investigate salivary a-syn as molecular disease biomarkers, assessing their potential diagnosis differential on respect Alzheimer's (AD) Parkinson's (PD). Methods We measured total oligomeric a-syn, total-tau, S199-phosphorylated-tau (pS199-tau) 21 DLB, 20 AD, PD patients, healthy subjects (HS) using quantitative enzyme-linked immunosorbent assay (ELISA) analyses. Results Salivary was not significantly changed between groups, whereas all pathological groups had a higher concentration HS. total-tau HS, concentrations did differ patients’ groups. Conversely, levels pS199-tau AD HS patients. Both correlation matrix principal component analysis showed that core clinical features were related pathology, while cognitive decline associated both Receiver operating characteristic reported high diagnostic accuracy oligomers pS199-tau, adequate PD. optimal Conclusions These findings provide preliminary evidence might be promising identifying is limited AD.

Язык: Английский

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