Metabolites, Год журнала: 2025, Номер 15(3), С. 179 - 179

Опубликована: Март 6, 2025

Background/Objectives: Prenatal depression (PND) poses a significant threat to the health of both mother and developing fetus. Despite its increasing prevalence, pathophysiology PND is not yet fully elucidated. Methods: In this study, we aimed investigate fecal metabolites gut microbiota in patients compared healthy controls explore potential correlations between these factors. Results: Through untargeted metabolomics analysis, identified 75 significantly altered patients, which 27 were structurally annotated implicated key pathways, such as linoleic acid metabolism phenylalanine, tyrosine, tryptophan biosynthesis. Notably, two Clostridia-associated enterobacteria, unclassified_c_Clostridia unclassified_f_Lachnospiraceae, enriched group, positively correlated with tyrosine negatively multiple sulfated neurosteroids. Conclusions: Our findings underscore robust association dysbiosis metabolic disturbances PND, specific alterations noted metabolism, neurosteroid homeostasis, pathways. These dysregulated metabolites-tyrosine, neurosteroids, acid-may serve diagnostic biomarkers therapeutic targets. Moreover, their interplay provides new insights into pathophysiological mechanisms particularly highlighting role gut-brain axis signaling neuroendocrine dysregulation inflammatory responses. However, further large-scale studies animal models are required validate detailed mechanistic

Язык: Английский