Liquid biopsy: an emerging field with new opportunities for cancer diagnosis and prognosis
Asia-Pacific Journal of Oncology,
Год журнала:
2025,
Номер
unknown, С. 9 - 17
Опубликована: Янв. 14, 2025
Cancer
grades
among
the
deadliest
diseases,
globally
causing
death
of
a
over
million
people
each
year.
Early
diagnosis
has
been
considered
ideal
for
efficient
treatment
as
during
later
stages
chances
become
limited.
However,
gold
standard
tissue
biopsy
various
limitation
instance,
late-stage
and
its
intrusive
operation
making
it
unfit
repeated
sampling.
Scientists
are
passionately
looking
new
technologies
techniques
cancer
prognosis.
Liquid
emerged
diagnostic
prognostic
tool
cancer,
that
relies
on
body
fluids
to
identify
biomarkers
cancer.
It
offers
advantages
like
non-invasive
operation,
timely
detection,
amenable
sampling,
covers
tumor
heterogeneity.
Wide
attention
garnered
by
liquid
is
undergoing
rapid
progress
in
list
target
biomarkers.
The
most
common
circulating
cells,
DNA,
exosomes,
educated
platelets,
non-coding
RNAs
(miRNA,
lncRNA
etc.).
Each
these
have
unique
advantages,
indeed
technology
future
with
clinical
utility.
In
this
article,
we
tried
provide
thorough
introduction
markers,
highlighted
deployed
biopsy,
briefly
overview
their
implications
indispensable
entities
diverse
types
Moreover,
discussed
prospects
revolutionary
realm
treatment.
Язык: Английский
The Current Roadmap of Lung Cancer Biology, Genomics and Racial Disparity
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(8), С. 3818 - 3818
Опубликована: Апрель 17, 2025
Globally,
lung
cancer
is
the
most
prevalent
cause
of
cancer-related
death.
There
are
two
large
histological
groups
cancer:
small-cell
(SCLC)
and
non-small-cell
(NSCLC).
Based
on
histopathological
molecular
features,
adenocarcinoma
(ADC)
squamous
cell
carcinoma
(SCC)
major
histologic
subtypes
NSCLC.
Various
epidemiological
environmental
factors
linked
with
an
increased
risk
cancer.
However,
these
show
disparities
in
patients
divergent
racial
ethnic
backgrounds.
Interestingly,
different
populations
were
found
to
harbor
distinct
features
as
evidenced
by
variations
genetic
mutation
profiles.
Moreover,
diverse
progression
patterns
identified
cancer,
which
could
be
crucial
improving
diagnosis,
prognosis,
therapeutic
planning.
In
concert
a
plethora
nuclear
alterations,
mitochondrial
alteration,
epigenetic
reprogramming,
microbial
dysbiosis,
immune
alteration
signatures
have
been
various
types.
This
review
article
provides
comprehensive
overview
screening
tests
treatment
strategies
for
NSCLC
SCLC,
including
surgery,
radiation
therapy,
chemotherapy,
targeted
therapies,
immunotherapies.
Through
unification
aspects,
this
aspires
complete
understanding
cancer’s
genomics,
biology,
landscapes,
disparity
seeks
understand
essential
role
occurrence
treatment.
Язык: Английский