Brazilian Journal of Physics, Год журнала: 2024, Номер 54(5)
Опубликована: Июль 31, 2024
Язык: Английский
Journal of Functional Biomaterials, Год журнала: 2025, Номер 16(1), С. 24 - 24
Опубликована: Янв. 14, 2025
Autoimmune diseases present complex therapeutic challenges due to their chronic nature, systemic impact, and requirement for precise immunomodulation avoid adverse side effects. Recent advancements in biodegradable stimuli-responsive nanomaterials have opened new avenues targeted drug delivery systems capable of addressing these challenges. This review provides a comprehensive analysis state-of-the-art nanocarriers such as polymeric nanoparticles, liposomes, hydrogels engineered autoimmune therapies. These are designed degrade safely the body while releasing agents response specific stimuli, including pH, temperature, redox conditions, enzymatic activity. By achieving localized controlled release anti-inflammatory immunosuppressive agents, minimize toxicity enhance efficacy. We discuss underlying mechanisms nanomaterials, recent applications treating rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, design considerations essential clinical translation. Additionally, we address current challenges, biocompatibility, scalability, regulatory hurdles, well future directions integrating advanced nanotechnology with personalized medicine treatment. highlights transformative potential presenting them promising strategy advance precision improve patient outcomes disease management.
Язык: Английский
Процитировано
5
ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown
Опубликована: Янв. 8, 2025
Nanomedicine is revolutionizing precision medicine, providing targeted, personalized treatment options. Lipid-based nanomedicines offer distinct benefits including high potency, targeted delivery, extended retention in the body, reduced toxicity, and lower required doses. These characteristics make lipid-based nanoparticles ideal for drug delivery areas such as gene therapy, cancer treatment, mRNA vaccines. However, traditional bulk synthesis methods LNPs often produce larger particle sizes, significant polydispersity, low encapsulation efficiency, which can reduce therapeutic effectiveness. issues primarily result from uneven mixing limited control over formation during synthesis. Microfluidic technology has emerged a solution, precise size, uniformity, efficiency. In this mini review, we introduce state-of-the-art microfluidic systems nanoparticle functionalization. We include working principles of different types systems, use LNP synthesis, cargo encapsulation, nanomedicine delivery. end, briefly discuss clinical enabled by devices.
Язык: Английский
Процитировано
3
Pharmaceutics, Год журнала: 2024, Номер 16(5), С. 670 - 670
Опубликована: Май 16, 2024
In recent years, biopolymer-based nano-drug delivery systems with antioxidative properties have gained significant attention in the field of pharmaceutical research. These offer promising strategies for targeted and controlled drug while also providing antioxidant effects that can mitigate oxidative stress-related diseases. Generally, healthcare landscape is constantly evolving, necessitating continual development innovative therapeutic approaches (DDSs). DDSs play a pivotal role enhancing treatment efficacy, minimizing adverse effects, optimizing patient compliance. Among these, nanotechnology-driven garnered due to their unique properties, such as improved solubility, release, delivery. Nanomaterials, including nanoparticles, nanocapsules, nanotubes, etc., versatile platforms tissue engineering applications. Additionally, hold immense promise, leveraging natural or synthetic biopolymers encapsulate drugs enable release. numerous advantages, biocompatibility, biodegradability, low immunogenicity. The utilization polysaccharides, polynucleotides, proteins, polyesters biopolymer matrices further enhances versatility applicability DDSs. Moreover, substances emerged key players combating diseases, offering protection against cellular damage chronic illnesses. nanoformulations represents burgeoning research area, substantial increase publications years. This review provides comprehensive overview developments within this area over past five It discusses various materials, fabrication techniques, stabilizers, factors influencing degradation, it highlights emerging trends, challenges, prospects rapidly evolving field.
Язык: Английский
Процитировано
13
Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 178 - 178
Опубликована: Янв. 31, 2025
Lipid nanoparticles (LNPs) are versatile delivery systems with high interest because they allow the release of hydrophobic and hydrophilic molecules, such as essential oils (EOs) plant extracts. This review covers published works between 2019 2024 that have reported use EO-based LNPs antimicrobial properties applications in human animal health, well biopesticides. In healthcare field, reports addressed effect encapsulating EOs lipid nanosystems antiviral, antibacterial, antiprotozoal antifungal activities. care, this still needs to be more deeply explored while looking for sustainable alternatives against different types parasites affect health. Overall, antibacterial activities carrying described synthetic antibiotics. field agriculture, studies showed these approaches control phytopathogens other pests food production. There is a growing demand innovative technologies. However, there some challenges overcome order innovations reach market.
Язык: Английский
Процитировано
2
Polymers, Год журнала: 2025, Номер 17(7), С. 833 - 833
Опубликована: Март 21, 2025
Polymeric nanoparticles (PNPs) represent a groundbreaking advancement in targeted drug delivery, offering significant benefits over conventional systems. This includes their versatility, biocompatibility, and ability to encapsulate diverse therapeutic agents provide controlled release, improving efficacy while minimizing side effects. The polymers used PNP formulations are critical, as they influence the nanoparticles' physicochemical properties such size, shape, surface charge, drug-loading capacity. Recent developments polymer chemistry nanotechnology have led creation of smart PNPs that can respond specific stimuli, enabling precise release environments. review explores mechanisms innovations polymeric formulations, fabrication characterization techniques enhance delivery Additionally, it discusses challenges future directions field, highlighting potential for personalized medicine role artificial intelligence optimizing nanoparticle design. By examining relationship between characteristics performance, aims promote innovative strategies modern medicine. Despite promise polymer-based systems, toxicity, stability, scalability, regulatory compliance must be addressed. Future research should focus on rigorous testing, clear risk communication, sustainable practices support clinical translation commercial viability. Overall, integration these elements is crucial advancing applications.
Язык: Английский
Процитировано
2
Expert Opinion on Drug Delivery, Год журнала: 2024, Номер 21(10), С. 1479 - 1490
Опубликована: Окт. 2, 2024
Nanoparticles (NPs) are widely used in the pharmaceutical field to treat various human disorders. Among these, lipid-based NPs (LNPs), including solid lipid nanoparticles (SLN) and nanostructured carriers (NLC), favored for drug/bioactive delivery due their high stability, biocompatibility, encapsulation efficiency, sustained/controlled release. These properties make them particularly suitable as of compounds derived from plant sources.
Язык: Английский
Процитировано
7
BIO Integration, Год журнала: 2025, Номер 6(1)
Опубликована: Янв. 1, 2025
Lipid-based Nanoparticles (LBNPs) have emerged as a transformative approach in cancer treatment, offering innovative drug delivery solutions that enhance therapeutic efficacy while minimizing adverse effects. By exploring the characterization, classification, synthesis, targeting strategies, and advantages of LBNPs, this study highlights how LBNPs been used to overcome limitations traditional chemotherapy improve patient outcomes. As nanotechnology revolutionizes therapy, emergence promising strategy for targeted has led optimism regarding future treatment. This review extensively assesses structure, categories, production methods, benefits, recent advancements treating cancer. It also current challenges possible directions. is aimed at providing comprehensive understanding LBNPs’ potential therapy. Liposomes, nanostructured lipid carriers, solid nanoparticles, lipid-polymer hybrid nanoparticles are all types each with unique features interest These particles can be synthesized through various procedures, such bulk nanoprecipitation, solvent-based emulsification, or microfluidics. Passive systems, active responsive platforms direct tumors. Consequently, provide an improved release pattern minimizes side effects enhancing efficacy. With combination offer hopeful Continued research expected outcomes overall quality life care.
Язык: Английский
Процитировано
1
International Journal of Pharmaceutics X, Год журнала: 2024, Номер 8, С. 100283 - 100283
Опубликована: Сен. 10, 2024
Язык: Английский
Процитировано
6
Nanomaterials, Год журнала: 2024, Номер 14(11), С. 902 - 902
Опубликована: Май 21, 2024
This study’s main objective was to fabricate an innovative three-dimensional microfluidic platform suitable for well-controlled chemical syntheses required producing fine-tuned nanostructured materials. work proposes using vortex mixing principles confined within a 3D multilayered microreactor synthesize magnetic core-shell nanoparticles with tailored dimensions and polydispersity. The newly designed allowed the simultaneous obtainment of Fe3O4 cores their functionalization salicylic acid shell in short reaction time under high flow rate. Synthesis optimization also performed, employing variation reagents ratio highlight concentration domains which magnetite is mainly produced, formation different diameters low polydispersity, stability colloidal dispersions water. obtained materials were further characterized by X-ray diffraction (XRD), Fourier-transform infrared (FT-IR) spectroscopy, dynamic light scattering (DLS), transmission electron microscopy (TEM), experimental results confirming production acid-functionalized iron oxide (Fe3O4-SA) adapted applications.
Язык: Английский
Процитировано
5
Micromachines, Год журнала: 2025, Номер 16(1), С. 95 - 95
Опубликована: Янв. 15, 2025
Chronic lymphocytic leukemia (CLL), the most common type of leukemia, remains incurable with conventional therapy. Despite advances in therapies targeting Bruton's tyrosine kinase and anti-apoptotic protein BCL-2, little is known about their effect on red blood cell (RBC) aggregation flow. In this study, we applied a microfluidic device newly developed Software Image Flow Analysis to assess extent RBC CLL patients elucidate hemorheological effects commonly therapeutics Obinutuzumab/Venetoclax Ibrutinib. The results revealed that, samples from untreated patients, complex 3D clusters large aggregates are formed, number significantly increased compared healthy control samples. application combination did not affect aspect RBCs' rheological behavior. contrast, targeted therapy Ibrutinib preserves state RBCs levels seen controls, demonstrating that mitigates alterations properties associated CLL. Our findings highlight impact different properties, which critical for predicting potential complications side treatments, particularly concerning flow dynamics.
Язык: Английский
Процитировано
0