The
importance
of
diet
shaping
the
gut
microbiota
is
well
known
and
may
help
with
improving
overall
health
an
individual.
Many
other
factors
also
have
influence,
such
as
genetics,
age,
exercise,
antibiotic
therapy,
or
tobacco
use.
purpose
this
review
to
summarize
how
three
distinct
dietary
types
(plant-based
diet,
Mediterranean
Western
diet)
affect
composition
development
non-communicable
diseases
(NCDs).
PubMed,
Web
Science
Scopus
databases
were
used
for
searching
papers
emphasis
on
keywords
‘‘dietary
pattern’’,
‘‘gut
microbiota’’
‘‘dysbiosis’’.
Plant-based
promote
production
beneficial
bacterial
products,
more
microbial
diversity
therefore
are
generally
considered
healthy
types.
On
hand,
a
typical
example
unhealthy
approach
nutrition
which
leads
overgrowth
pathogenic
bacteria.
Moreover,
understanding
impact
modulation
give
rise
new
therapeutical
strategies.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Апрель 30, 2024
Abstract
Hyperuricemia
(HUA)
is
a
symptom
of
high
blood
uric
acid
(UA)
levels,
which
causes
disorders
such
as
gout
and
renal
urinary
calculus.
Prolonged
HUA
often
associated
with
hypertension,
atherosclerosis,
diabetes
mellitus,
chronic
kidney
disease.
Studies
have
shown
that
gut
microbiota
(GM)
affect
these
diseases.
This
study
aimed
to
determine
the
relationship
between
GM.
The
microbiome
224
men
254
women
aged
40
years
was
analyzed
through
next-generation
sequencing
machine
learning.
We
obtained
GM
data
16S
rRNA-based
fecal
samples,
finding
alpha-diversity
by
Shannon
index
significantly
low
in
group.
Linear
discriminant
effect
size
analysis
detected
abundance
genera
Collinsella
Faecalibacterium
non-HUA
groups.
Based
on
light
gradient
boosting
learning,
we
propose
can
be
predicted
AUC
using
four
clinical
characteristics
relative
nine
bacterial
genera,
including
Dorea
.
In
addition,
causal
relationships
direct
linear
non-Gaussian
acyclic
model
indicated
positive
genus
UA
levels.
Our
results
suggest
abundant
increase
Medicine,
Год журнала:
2024,
Номер
103(13), С. e37628 - e37628
Опубликована: Март 29, 2024
Growing
evidence
has
suggested
that
gut
microbiota
is
associated
with
gynecologic
cancers.
However,
whether
there
a
causal
relationship
between
these
associations
remains
to
be
determined.
A
two-sample
Mendelian
randomization
(MR)
evaluation
was
carried
out
investigate
the
mechanism
associating
and
3
prevalent
gynecological
cancers,
ovarian
cancer
(OC),
endometrial
cancer,
cervical
as
well
their
subtypes
in
individuals
of
European
ancestry.
The
Genome-wide
association
studies
statistics,
which
are
publically
accessible,
were
used.
Eligible
instrumental
single
nucleotide
polymorphisms
significantly
related
selected.
Multiple
MR
analysis
approaches
out,
including
inverse
variance
weighted,
MR-Egger,
Weighted
Median
methods,
range
sensitivity
analyses.
Lastly,
we
undertook
reverse
evaluate
potential
causality.
We
sifted
through
196
bacterial
taxa
identified
33
suggestive
relationships
genetic
liability
found
11
genera
could
pathogenic
risk
factors
for
while
19
lessen
cancer.
In
other
direction,
cancers
altered
composition.
Our
revealed
causally
OC,
This
may
assist
providing
new
insights
further
mechanistic
clinical
microbiota-mediated
Ecology and Evolution,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 1, 2025
ABSTRACT
Gut
microbiota
are
fundamental
for
healthy
animal
function,
but
the
evidence
that
host
function
can
be
predicted
from
taxonomy
remains
equivocal,
and
natural
populations
remain
understudied
compared
to
laboratory
animals.
Paired
analyses
of
covariation
in
parameters
powerful
approaches
characterise
host–microbiome
relationships
mechanistically,
especially
wild
animals
also
lab
models,
enabling
insight
into
ecological
basis
at
molecular
cellular
levels.
The
fruitfly
Drosophila
melanogaster
is
a
preeminent
model
organism,
amenable
field
investigation
by
‘omic
analyses.
Previous
work
male
D.
guts
analysed
paired
measurements
(A)
bacterial
diversity
abundance,
measured
16S
amplicon
sequencing;
(B)
gut
transcriptome,
no
signature
was
detected.
Here,
we
re‐analyse
those
data
comprehensively.
We
find
orthogonal
axes
microbial
genera,
which
correspond
differential
expression
genes.
differentially
expressed
gene
sets
were
enriched
functions
including
protein
translation,
mitochondrial
respiration,
immunity
reproduction.
Each
set
had
distinct
functional
signature,
suggesting
flies
exhibit
range
variation,
microbiome
variation.
These
findings
lay
foundation
better
connect
ecology
genetics
leading
host‐microbiome
model.
Advanced Sensor Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 2, 2025
Abstract
Advancements
in
sensor
technologies
capable
of
measuring
key
biomarkers
can
greatly
enhance
medical
diagnostics
and
health
monitoring,
facilitating
more
effective
diagnosis,
treatment,
prevention.
While
there
are
numerous
interest,
gaseous
ammonia
(NH
3
)
stands
out
due
to
its
significance
as
an
indicator
organ
function
(e.g.,
liver
kidney
failure)
or
bacterial
infections
Helicobacter
pylori
,
Proteus
mirabilis
the
body.
This
review
discusses
metabolism
presence
NH
body
organs,
well
clinical
conditions
associated
with
regulation
concentrations.
paper
reviews
various
sensing
materials
parameters,
along
current
state‐of‐the‐art
gas
sensors
detecting
for
biomedical
applications.
Additionally,
it
addresses
challenges
faced
by
already
use
highlights
that
while
applications
breath
analysis
well‐developed,
vivo
remains
early
stages
faces
significant
challenges.
Finally,
promising
future
research
directions
discussed,
including
integration
catheters
Simulator
Human
Intestinal
Microbial
Ecosystem,
detection
antibiotic‐resistant
bacteria
diagnostics.
Nutrition Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Although
the
human
gut
microbiome,
and
its
role
in
health
disease,
have
been
extensively
studied
different
populations,
a
comprehensive
assessment
of
microbiome
composition
has
not
performed
vulnerable
refugee
populations.
In
this
study,
we
hypothesized
that
overall
nutritional
status,
as
indicated
by
serum
micronutrients
concentrations,
is
an
important
driver
variations
composition.
Therefore,
gut-microbiome
diversity
associated
demographic,
factors
were
assessed
adolescent
Afghan
refugees
(n=206).
Blood
faecal
samples
collected
analysed
for
nutrition
status
markers
16S
rRNA
gene
amplicon-based
community
profiling,
respectively.
Bioinformatics
statistical
analysis
using
SPSS,
QIIME
R.
Overall,
56
distinct
phyla,
117
families
252
genera
identified
samples.
Bacterial
(alpha
beta
diversity)
Firmicutes:Bacteroidetes
(F/B)
ratio
significantly
higher
15
to
19
year
old
age
group
(cf.
10-14
group)
but
lower
underweight
vitamin
D
deficient
groups.
Furthermore,
LEfSe
significant
differences
relative
abundance
bacterial
based
on
age,
BMI
micronutrient
(vitamins
minerals)
status.
These
results
further
scrutinised
correlation
which
confirmed
show
correlations
with
F/B
specific
taxa.
Collectively,
our
study
provides
first
indication
how
gut-microbiota
profile
range
nutrition-status
factors.
findings
can
thus
provide
basis
translational
microbiota
research
aimed
at
improving
such
understudied
