The Roles of Functional Bacterial Amyloids in Neurological Physiology and Pathophysiology: Pros and Cons for Neurodegeneration

Microbial Pathogenesis, Год журнала: 2025, Номер unknown, С. 107363 - 107363

Опубликована: Фев. 1, 2025

Язык: Английский

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Black raspberry supplementation on overweight and Helicobacter pylori infected mild dementia patients a pilot study

npj Science of Food, Год журнала: 2025, Номер 9(1)

Опубликована: Фев. 12, 2025

Язык: Английский

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Extracellular vesicles from Lacticaseibacillus paracasei reduce neuroinflammation in hippocampus and restore some cognitive functions in hyperammonemic rats

Microbiological Research, Год журнала: 2025, Номер 294, С. 128101 - 128101

Опубликована: Фев. 14, 2025

Язык: Английский

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Traumatic Brain Injury and Gut Microbiome: The Role of the Gut-Brain Axis in Neurodegenerative Processes

Current Neurology and Neuroscience Reports, Год журнала: 2025, Номер 25(1)

Опубликована: Март 15, 2025

Язык: Английский

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Effect of probiotics on cognitive function and cardiovascular risk factors in mild cognitive impairment and Alzheimer’s disease: an umbrella meta-analysis

Journal of Health Population and Nutrition, Год журнала: 2025, Номер 44(1)

Опубликована: Апрель 8, 2025

This umbrella meta-analysis evaluates the effects of probiotics on cognitive function and metabolic health in Alzheimer's disease (AD) mild impairment (MCI) by synthesizing findings from meta-analyses randomized controlled trials (RCTs), as existing evidence remains inconclusive. A systematic search was conducted PubMed, Web Science, Scopus to identify RCTs investigating impact probiotic supplementation biomarkers. The random-effects model used. Heterogeneity publication bias were assessed. Thirteen meta-analyses, comprising 3910 patients, included. Probiotics significantly improved AD (SMD = 0.78, 95% CI: 0.33 1.23) MCI 0.43, 0.15 0.70). also increased total antioxidant capacity 0.40, 0.11 0.70) reduced MDA - 0.35, 0.62 0.09) hs-CRP 0.59, 0.87 0.30). Insulin resistance improved, reflected decreased HOMA-IR 0.34, 0.43 0.26). No significant observed glutathione, nitric oxide, or lipid profiles. Probiotic appears enhance parameters individuals with AD, likely through mechanisms involving inflammation reduction, oxidative stress modulation, insulin sensitivity. Further high-quality are required validate these determine optimal formulations.

Язык: Английский

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Insights into the Current and Possible Future Use of Opioid Antagonists in Relation to Opioid-Induced Constipation and Dysbiosis

Molecules, Год журнала: 2023, Номер 28(23), С. 7766 - 7766

Опубликована: Ноя. 24, 2023

Opioid receptor agonists, particularly those that activate µ-opioid receptors (MORs), are essential analgesic agents for acute or chronic mild to severe pain treatment. However, their use has raised concerns including, among others, intestinal dysbiosis. In addition, growing data on constipation-evoked dysbiosis have been reported. Opioid-induced constipation (OIC) creates an obstacle continuing treatment with opioid analgesics. When non-opioid therapies fail overcome the OIC, antagonists peripheral, fast first-pass metabolism, and gastrointestinal localized effects remain drug of choice which discussed here. At first glance, seems only be restricted constipation, however, recent OIC-related its contribution appearance several side garnered a great attention from researchers. Peripheral MORs also considered as future target analgesics limited central effects. The properties MOR counteracting influence possibly peripheral MOR-mediated antinociception, will highlighted. A new concept is proposed developing gut-selective treat restore OIC while keeping antinociception unaffected. impact in relation changes gut microbiome included.

Язык: Английский

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Gut-brain axis: gut dysbiosis and psychiatric disorders in Alzheimer’s and Parkinson’s disease

Frontiers in Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Ноя. 13, 2023

Gut dysbiosis and psychiatric symptoms are common early manifestations of Alzheimer's disease (AD) Parkinson's (PD). These diseases, characterised by progressive neuron loss pathological protein accumulation, impose debilitating effects on patients. Recently, these proteins have been linked with gut disorders. The gut-brain axis links the enteric central nervous systems, acting as a bidirectional communication pathway to influence brain function behavior. relationship triad between dysbiosis, disorders, neurodegeneration has investigated in pairs; however, evidence suggests that they all interrelated deeper understanding is required unravel nuances neurodegenerative diseases. Therefore, this review aims summarise current literature roles disorders protein-related We discussed how changes environment can development progression features overlap AD PD. Moreover, research interplay remains its phase. In review, we highlighted potential therapeutic approaches aimed at mitigating gastrointestinal problems alter rate neurodegeneration. Further assess molecular mechanisms underlying PD pathogenesis crucial for developing more effective treatments achieving earlier diagnoses. exploring non-invasive, preventive measures interventions relatively unexplored but important avenue

Язык: Английский

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Modulation of gut microbiota with probiotics as a strategy to counteract endogenous and exogenous neurotoxicity

Advances in neurotoxicology, Год журнала: 2024, Номер unknown, С. 133 - 176

Опубликована: Янв. 1, 2024

Язык: Английский

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Innovative mechanisms of micro- and nanoplastic-induced brain injury: Emphasis on the microbiota-gut-brain axis

Life Sciences, Год журнала: 2024, Номер 357, С. 123107 - 123107

Опубликована: Окт. 5, 2024

Язык: Английский

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A Review on the Protective Effects of Probiotics against Alzheimer’s Disease

Biology, Год журнала: 2023, Номер 13(1), С. 8 - 8

Опубликована: Дек. 22, 2023

This review summarizes the protective effects of probiotics against Alzheimer’s disease (AD), one most common neurodegenerative disorders affecting older adults. is characterized by deposition tau and amyloid β peptide (Aβ) in different parts brain. Symptoms observed patients with AD include struggles writing, speech, memory, knowledge. The gut microbiota reportedly plays an important role brain functioning due to its bidirectional communication via gut–brain axis. emotional cognitive centers are linked functions peripheral intestinal system this Dysbiosis has been disorders, indicating significance homeostasis for proper function. Probiotics play protecting symptoms as they restore a great extent. characteristics, status axis, AD. Review research articles related treatment were searched PubMed database. Recent studies conducted using animal models given preference. clinical trials separately. Several on human clearly explain benefits improving cognition memory experimental subjects. Based these studies, novel therapeutic approaches can be designed

Язык: Английский

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