Current Issues in Molecular Biology, Год журнала: 2024, Номер 46(11), С. 12641 - 12657
Опубликована: Ноя. 7, 2024
The oral microbiome, comprising bacteria, fungi, viruses, and protozoa, is essential for maintaining both systemic health. This complex ecosystem includes over 700 bacterial species, such as
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 2721 - 2721
Опубликована: Фев. 27, 2024
Periodontitis is a complex condition. Left untreated, it leads to tooth loss and the need for prosthetic treatment. The incidence of periodontitis steadily increasing, so new methods are being sought aid in diagnosis disease. Among postulated determination concentrations bioactive compounds which include extracellular matrix metalloproteinases (MMPs). These enzymes present various structural elements stomatognathic system. most promising enzyme this group appears be metalloproteinase 8 (MMP-8). MMP-8 assays performed gingival fluid or saliva, levels have been shown higher patients with compared healthy subjects correlated some clinical parameters condition severity In addition, preliminary usefulness evaluating effectiveness periodontal treatment doxycycline therapy has demonstrated. Determination active form (aMMP-8) oral rinse using off-the-shelf shows highest potential. Despite reports about aMMP-8 data on role diagnosis, clear requires further research.
Язык: Английский
Процитировано
7
Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12
Опубликована: Май 28, 2024
Periodontitis is an inflammation-related condition, caused by infectious microbiome and host defense that causes damage to periodontium. The natural processes of the mouth, like saliva production eating, significantly diminish therapeutic medication residency in region periodontal disease. Furthermore, complexity diversity pathological mechanisms make successful periodontitis treatment challenging. As a result, developing enhanced local drug delivery technologies logical therapy procedures provides foundation for effective treatment. Being biocompatible, biodegradable, easily administered tissues, hydrogels have sparked substantial intense curiosity discipline therapy. primary objective hydrogel research has changed recent years intelligent thermosensitive hydrogels, involve adjustable sol-gel transformations regulate release reaction temperature, we present thorough introduction creation efficient construction new regeneration. We also address cutting-edge smart options based on pathophysiology. problems prospective study objectives are reviewed, with focus establishing methods clinical applications.
Язык: Английский
Процитировано
6
Journal of Neuroinflammation, Год журнала: 2024, Номер 21(1)
Опубликована: Июнь 6, 2024
Abstract Central nervous system infections have been suggested as a possible cause for neurodegenerative diseases, particularly sporadic cases. They trigger neuroinflammation which is considered integrally involved in processes. In this review, we will look at data linking variety of viral, bacterial, fungal, and protozoan to Alzheimer’s disease, Parkinson’s amyotrophic lateral sclerosis, multiple sclerosis unspecified dementia. This narrative review aims bring together broad range currently supporting the involvement central development diseases. The idea that no single pathogen or group responsible diseases be discussed. Instead, suggest wide susceptibility factors may make individuals differentially vulnerable different infectious pathogens subsequent pathologies.
Язык: Английский
Процитировано
5
Journal Of Clinical Periodontology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 8, 2025
ABSTRACT Aim Neurodegenerative diseases are characterized by early increased beta‐amyloid (Aβ) and decreased cerebrovascular reactivity. We investigated Aβ in gingiva, serum or hippocampus neurovascular reactivity basilar artery (BA) of periodontitis rats, to test the impact on BA vasoreactivity ex vivo. Materials Methods Periodontitis was induced 32 rats using silk‐ligation. Rats were sacrificed at weeks 0, 1, 2 4. Gingival TNF‐α, IL‐1β quantified via immunoblotting. Alveolar bone destruction examined micro‐computed tomography. Serum values measured enzyme‐linked immunosorbent assay fluorescence staining, respectively. Vasoreactivity myography isolated BA. Results From Week gingival TNF‐α increased. Gingiva, from 2. Nicotine‐induced relaxation declined 2, while acetylcholine‐induced Bone loss correlated with nicotine‐induced relaxation. Correlations observed between Aβs tissues, two relaxations expressions relaxations. Ex vivo, reduced nicotine‐ isoproterenol‐induced but not electrical stimulated Conclusions may increase reduce reactivity, contributing this abnormal coupling.
Язык: Английский
Процитировано
0
Biomedicines, Год журнала: 2024, Номер 12(4), С. 792 - 792
Опубликована: Апрель 3, 2024
Recent research suggests a potential relevance between chronic periodontitis (CP) and Parkinson’s disease (PD), raising concerns about comorbid PD among elderly CP patients. However, the epidemiologic basis for this association remains unclear. Employing nested case-control design, study explored subsequent occurrences in Korean adults, leveraging validated national population-based dataset covering period from 2002 to 2019. It included 8794 patients 35,176 matched control individuals, established through propensity score matching age, sex, residential area, income. Baseline characteristics were compared using standardized differences, logistic regression was employed assess impact of histories on likelihood while controlling covariates. We performed thorough examination events within both 1-year 2-year intervals preceding index date, incorporating subgroup analyses. Our analysis revealed no statistically significant history development overall. slightly increased individuals with high burden (Charlson Comorbidity Index ≥ 2). In conclusion, although our did not find overall development, elevated subgroups may suggest that comorbidities influence probability certain Considering conditions screening some be also important.
Язык: Английский
Процитировано
4
Biomedicines, Год журнала: 2024, Номер 12(4), С. 882 - 882
Опубликована: Апрель 16, 2024
Aim. The sulfhydryl (thiols) group of glutathione plays an important role in the neutralization foreign organic compounds and reduction peroxides. purpose study is to evaluate concentration groups gingival tissue healthy individuals those with gingivitis or periodontitis, examine differences between these groups. Material methods. To assess we used spectrophotometric analysis using dithionitrobenzoate (DTNB) as a reagent measure accessible present proteins. sample was divided into three distinct groups: periodontal health, gingivitis, different indices were status participants. Next, statistical conducted compare concentrations among patients. Conclusions. results this showed significantly decreased levels from patients compared people (control group). These confirm defense against free radicals. They share significant detoxification, signal transduction, apoptosis, various other functions at molecular level.
Язык: Английский
Процитировано
4
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Июнь 11, 2024
Periodontal disease is a chronic inflammatory condition that affects the supporting structures of teeth, including periodontal ligament and alveolar bone. due to an immune response stimulates gingivitis periodontitis, its systemic consequences. This triggered by bacteria may be modulated environmental conditions such as smoking or disease. Recent advances in single cell RNA-seq (scRNA-seq) vivo animal studies have provided new insight into causes periodontitis gingivitis. Dysbiosis, which constitutes change bacterial composition microbiome, key factor initiation progression periodontitis. The host dysbiosis involves activation various types, keratinocytes, stromal cells, neutrophils, monocytes/macrophages, dendritic cells several lymphocyte subsets, release pro-inflammatory cytokines chemokines. has been implicated contributing pathogenesis conditions, diabetes, rheumatoid arthritis, cardiovascular Alzheimer’s Understanding complex interplay between oral microbiome critical for development therapeutic strategies prevention treatment
Язык: Английский
Процитировано
4
Archives of Microbiology, Год журнала: 2025, Номер 207(2)
Опубликована: Янв. 18, 2025
Язык: Английский
Процитировано
0
PLoS Pathogens, Год журнала: 2025, Номер 21(1), С. e1012821 - e1012821
Опубликована: Янв. 21, 2025
Porphyromonas gingivalis (Pg) is a keystone pathogen in periodontitis, highly prevalent disease manifested by chronic inflammation of the periodontium, alveolar bone resorption and tooth loss. During periodontitis pathobionts such as Pg can enter bloodstream growing evidence correlates with increased risk cardiovascular neurodegenerative diseases. However, mechanism which immune cells respond to challenge vivo remains elusive. produce aggressive proteolytic virulence factors termed gingipains not only provide nutrients necessary for bacterial growth, but also subvert host response, facilitating survival. Using transgenic zebrafish fluorescently labelled macrophages neutrophils, role survival interaction phagocytes during systemic local infection was examined. In contrast wild-type (W83) , isogenic gingipain-null ( ΔK/R-ab) or treated gingipain inhibitors caused less mortality, bacteria were rapidly phagocytosed, acidified phagosomes eradicated when systemically injected, showing that are instrumental preventing phagocytosis intracellular killing innate cells. Moreover, predominantly phagocytosed macrophages, depletion/inactivation injected either locally otic vesicle, internalised neutrophils. This phenomenon -specific Fusobacterium nucleatum neutrophil recruitment then effectively these bacteria. These data demonstrate important phagocytes, especially combating highlight crucial protective subverting response. study emphasizes advantages using interactions real-time, providing valuable experimental system testing new therapeutic strategies aimed at reducing periodontal-associated disease.
Язык: Английский
Процитировано
0
Clinical Oral Investigations, Год журнала: 2025, Номер 29(1)
Опубликована: Янв. 23, 2025
Язык: Английский
Процитировано
0