Assessment of phytochemical screening, antibacterial, analgesic, and antipyretic potentials of Litsea glutinosa (L.) leaves extracts in a mice model
PLoS ONE,
Год журнала:
2025,
Номер
20(1), С. e0309857 - e0309857
Опубликована: Янв. 31, 2025
Litsea
glutinosa
(LG)
leaves
have
been
traditionally
used
in
ethnomedicine
for
the
treatment
of
various
ailments,
including
pain,
fever,
and
microbial
infections.
This
study
aims
to
scientifically
evaluate
therapeutic
potential
cold
methanol
extracts
LG
leaves,
specifically
focusing
on
their
analgesic,
antipyretic,
antibacterial
activities.
In
addition,
research
includes
preliminary
phytochemical
screening
identify
key
bioactive
compounds
an
acute
toxicity
test
assess
safety
profile
extract.
this
study,
we
conducted
initial
investigation
major
groups
present
L.
using
both
modern
chromatographic
techniques,
High-Performance
Liquid
Chromatography
(HPLC),
conventional
methods
applied
extracts.
Both
approaches
consistently
identified
phenols
flavonoids
as
predominant
compounds.
Following
characterization,
assessed
analgesic
efficacy
acetic
acid-induced
writhing
electrical
heat-induced
nociceptive
pain
stimuli,
evaluated
antipyretic
effects
through
Brewer's
yeast-induced
pyrexia,
determined
activity
via
disc
diffusion
method.
Additionally,
was
preclinical
testing.
hot
plate
method,
highest
inhibitory
found
at
a
dose
500
mg/kg
crude
extract
(3.37
±
0.31
sec)
which
differed
significantly
(P
<
0.01
P
0.001)
with
that
standard
drug
morphine
(6.47
0.23
sec).
The
prolonged
reaction
latency
thermal-induced
hotplate
model.
Analgesic
mg/kg,
produced
70%
suppression
mice,
statistically
significant
(p
compared
morphine's
(77.5%)
inhibition.
assay,
showed
notable
reduction
body
temperature
(36.17
0.32
°C)
300
mg/kg-body
weight,
when
(at
100
weight)
exerted
(36.32
0.67
after
3
h
administration.
studies,
results
inhibition
bacterial
growth
400
μg
each
clearly
inhibited
bacteria
from
11
22
mm.
extractives
carbon
tetrachloride
fraction,
chloroform
soluble
ethyl
acetate
fraction
demonstrated
notably
greater
zone
widths
0.05)
against
tested
strains.
Overall,
demonstrates
settings.
Future
is
warranted
isolate
specific
elucidate
mechanisms
action
further
support
development
new
treatments
contributing
medicinal
practices
based
plant
leaves.
Язык: Английский
Sustainable Assessment of Bio-Colorant from Bakain Bark (Melia azedarach L.) for Dyeing of Cellulosic and Proteinous Fabric
Molecules,
Год журнала:
2024,
Номер
29(18), С. 4392 - 4392
Опубликована: Сен. 15, 2024
The
current
study
proceeded
to
reduce
the
environmental
hazards
spreading
worldwide
due
synthetic
dyes.
To
overcome
these
problems,
eco-friendly
natural
dyes
are
introduced
as
alternative
sources
of
present
was
focused
on
exploring
bio-colorant
aqueous
and
acidic
extract
bark
Melia
azedarach
L.
for
dyeing
both
silk
cotton
samples.
results
extraction
medium
specified
that
gave
maximum
colorant
solubility
upon
fabric
produced
higher
color
strength
in
contrast
medium.
optimization
experimentation
data
showed
excellent
found
at
45
min
time
duration,
35:1
mL
dye
extract,
using
2%
salt
(NaCl)
an
exhausting
agent,
whereas
K/S
value
60
time,
a
45:1
liquor
ratio,
with
use
salt.
Bio-mordants
produce
different
shades
fabrics.
Bio-mordanting
experiments
revealed
pre-mordanting
turmeric
3%
pomegranate,
post-mordanting
pomegranate
darker
shade.
In
case
cotton,
pre-mordanted
samples
post-mordanted
4%
highest
strengths.
All
mordanted
fastness
ratings.
Overall,
it
has
been
Bakain
proved
be
source
tannin.
result
this
could
cost-effective
textile
progress.
Язык: Английский
Phytochemical Investigation on Trichilia Elegans a. Juss (Meliaceae) and its Chemotaxonomic Significance
Опубликована: Янв. 1, 2024
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DOI
Язык: Английский
Assessment of the insecticidal efficacy of ethanol extract of Millettia pachyloba Drake leaves against Plutella xylostella Linnaeus moth
Journal of Plant Protection Research,
Год журнала:
2024,
Номер
unknown, С. 165 - 177
Опубликована: Апрель 9, 2024
Plutella
xylostella
(L.),
a
menacing
threat
to
cruciferous
crops,
exhibits
cross-resistance
various
chemical
agents.
The
exploration
of
plant-derived
insecticides
emerges
as
an
intervention
strategy
for
the
successful
management
P.
xylostella.
Millettia
pachyloba
Drake
is
renowned
traditional
remedy
diverse
health
issues
and
has
insecticidal
properties.
Experimental
investigations
in
both
laboratory
greenhouse
settings
utilized
M.
extract
(EMPE)
at
concentrations
ranging
from
2
10%
(w/v).
objectives
included
inducing
toxicity
controlling
larvae
effectively,
assessing
nutritional
impacts
through
parameters
like
relative
consumption
rate
(RCR),
growth
(RGR),
efficiency
conversion
digested
food
(ECD),
ingested
(ECI),
approximate
digestibility
(AD),
assimilation
ratio
(AR),
evaluating
leaf
damage
inflicted
by
on
Brassica
juncea.
In
laboratory,
application
EMPE
pupae
24,
48,
72
hours
yielded
markedly
higher
mortality
rates
than
water-treated
control
(p
<
0.05).
Significant
reductions
RGR,
RCR,
ECD,
ECI,
AD,
AR
were
evident
throughout
larval
stage
greenhouse,
treatments
demonstrated
notable
differences
water
treatment.
On
15th
day
treatment,
treatment
(w/v)
exhibited
highest
Significantly
reduced
was
observed
with
treatments,
displaying
inverse
correlation
escalating
concentrations.
Particularly,
enhancement
across
all
surveyed
which
comparable
positive
fipronil
>
Noteworthy
reduction
percentage
(DRP)
identified
between
contact
group
0.05),
indicating
promising
potential
pest
control.
Язык: Английский
Evaluation of the Effectiveness of Millettia pachyloba drake Leaf Ethanol Extract in Alleviating Oxidative Stress Induced by Diamondback Moth Infestation in Mustard Greens [Brassica juncea (L.) czern. & coss.]
Journal of Horticultural Research,
Год журнала:
2024,
Номер
32(1), С. 67 - 78
Опубликована: Июнь 1, 2024
Abstract
The
global
threat
that
the
diamondback
moth
(DBM)
(
Plutella
xylostella
)
poses
to
Brassica
juncea
creates
an
urgent
need
develop
effective
mitigation
strategies.
With
promising
findings,
this
study
explores
potential
of
plant-derived
antioxidants,
particularly
Millettia
pachyloba
,
in
mitigating
DBM-induced
oxidative
stress.
Greenhouse
experiments
conducted
using
M.
leaf
ethanol
extract
(MPEE)
at
concentrations
2,
4,
6,
8,
and
10
%
(w/v)
showed
inhibitory
effect
MPEE
on
DBM
damage
B.
.
comprehensive
assessment
included
effectiveness
reducing
stress
markers
(malondialdehyde,
hydrogen
peroxide),
augmenting
metabolites
(flavonoids,
phenolics),
enhancing
anti-oxidant
compounds
(glutathione,
ascorbic
acid,
total
protein),
stimulating
key
enzymes
(su-peroxide
dismutase,
catalase,
ascorbate
peroxidase).
results
were
compared
controls,
which
plants
treated
with
water
or
fipronil.
Fipronil
significantly
reduced
puncturing
damage,
impact
force
increased
concentration.
Both
types
protection
content
malondialdehyde
peroxide
leaves,
stems,
roots.
However,
a
significant
increase
flavonoids,
phenolic
antioxidant
proteins)
enzyme
activity
(superoxide
peroxidase,
catalase)
was
observed.
enhancement
metabolites,
enzymes,
antioxidants
comparable
fipronil
10%.
This
study,
its
replace
synthetic
extracts
reduce
induced
by
mustard
plants,
offers
solution
for
against
insect.
Язык: Английский