Food Research International, Год журнала: 2024, Номер 201, С. 115596 - 115596
Опубликована: Дек. 30, 2024
Язык: Английский
Applied Microbiology and Biotechnology, Год журнала: 2024, Номер 108(1)
Опубликована: Май 21, 2024
Abstract The human microbiome, a diverse ecosystem of microorganisms within the body, plays pivotal roles in health and disease. This review explores site-specific microbiomes, their role maintaining health, strategies for upkeep, focusing on oral, lung, vaginal, skin, gut microbiota, systemic connections. Understanding intricate relationships between these microbial communities is crucial unraveling mechanisms underlying health. Recent research highlights bidirectional communication distant microbiome sites, influencing immune function, metabolism, disease susceptibility. Alterations one can impact others, emphasizing interconnectedness collective influence physiology. therapeutic potential microbiota modulating microbiomes offers promising avenues interventions targeting various disorders. Through interdisciplinary collaboration technological advancements, we harness power to revolutionize healthcare, microbiome-centric approaches promote holistic well-being while identifying areas future research.
Язык: Английский
Процитировано
6
Journal of Inflammation Research, Год журнала: 2025, Номер Volume 18, С. 3039 - 3053
Опубликована: Фев. 28, 2025
Sjögren's disease, an autoimmune inflammatory currently lacks effective treatment options. The salivary gland, a crucial exocrine organ responsible for saliva production and local immune responses on mucous membranes, is frequently impaired in individuals with disease. Restoring gland function poses significant challenge researchers. Salivary epithelial cells, recognized as pivotal components of the have been increasingly implicated key initiators inflammation exhibit innate cell-like properties. On whole, SGEC plays protective role physiological state, can also participate persistence initiating factor pathological state. In review, we explore interplay between Ca+, endoplasmic reticulum (ER), mitochondrial homeostasis imbalance cells. Additionally, provide overview current literature research advancements related to Pattern Recognition Receptors (PRRs), programmed cell death, posttranslational modification (PTM), oral microecology, etc. specifically focusing their implications Given cells onset based may potential alleviate condition by addressing response glands.
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Cureus, Год журнала: 2024, Номер unknown
Опубликована: Июль 3, 2024
Nonalcoholic fatty liver disease (NAFLD) and periodontitis share common risk factors such as obesity, insulin resistance (IR), dyslipidemia, which contribute to systemic inflammation. It has been suggested that a bidirectional relationship exists between NAFLD periodontitis, indicating one condition may exacerbate the other. is characterized by excessive fat deposition in associated with low-grade chronic There are several for development of NAFLD, including gender, geriatric community, race, ethnicity, poor sleep quality deprivation, physical activity, nutritional status, dysbiosis gut microbiota, increased oxidative stress, overweight, higher body mass index (BMI), IR, type 2 diabetes mellitus (T2DM), metabolic syndrome (MetS), dyslipidemia (hypercholesterolemia), sarcopenia (decreased skeletal muscle mass). This inflammation can progression impairing immune responses exacerbating inflammatory processes periodontal tissues. Furthermore, individuals often exhibit altered lipid metabolism, affect oral microbiota composition, leading susceptibility disease. Conversely, linked through mechanisms involving stress. Chronic release pro-inflammatory cytokines bacterial toxins into bloodstream, contributing hepatic steatosis. Moreover, periodontitis-induced stress promote accumulation further aggravating NAFLD. The interplay underscores importance comprehensive management strategies targeting both conditions. Lifestyle modifications regular exercise, healthy diet, proper hygiene practices crucial preventing managing these interconnected diseases. Additionally, interdisciplinary collaboration hepatologists periodontists essential optimizing patient care improving outcomes periodontitis.
Язык: Английский
Процитировано
3
Bacteria, Год журнала: 2024, Номер 3(3), С. 209 - 222
Опубликована: Авг. 11, 2024
Oral health remains one of the most taken for granted parts human body health, even though poor oral has now been linked to various diseases, such as cancers, diabetes, autoimmune complications, neurological disorders, and cardiovascular disease, just name a few. As we review in this paper, substance use or abuse, including alcohol, smoking, recreational drugs, pharmaceutical drugs can have significant implications on which turn lead more systemic diseases. In show that microbiome dysbiosis inflammatory cytokine pathways are two mechanisms contributing complications from use. When decreases beneficial species increases periodontopathogenic strains, subsequent cascade oncogenic cytokines is triggered. review, explore these others determine consequences health. The findings significance clinically research fields substance-use-induced deterioration significantly reduces quality life daily functions. Overall, studies may provide valuable information future personalized medicine safer alternatives legal substances. Furthermore, they towards better rehabilitation preventative initiatives policies, it critical healthcare addiction aid specialists proper tools at their disposal.
Язык: Английский
Процитировано
3
Biology, Год журнала: 2024, Номер 13(3), С. 147 - 147
Опубликована: Фев. 27, 2024
The oral cavity serves as the primary path through which substances from outside world enter our body. Therefore, it functions a critical component of host defense. Saliva is essential for maintaining stable environment by catching harmful agents, including pathogens, allergens, and chemicals, in air or food. CCL28, highly expressed mucosal tissues, such colon salivary glands, chemokine that attracts CCR10/CCR3 expressing cells. However, role CCL28 gland formation remains unclear. In this study, we investigated structure CCL28-deficient mice. Histological analysis showed decreased staining intensity Alcian blue, detects acidic mucous, reduced expression MUC2, higher infiltration gram-positive bacteria glands addition, mice contained ectopically MUC2-expressed cells ducts cytokeratin 18, marker ductal cells, within submandibular resulting duct numbers. Additionally, several stem cell markers. These results suggest regulates saliva production via proper differentiation could be valuable biomarker function.
Язык: Английский
Процитировано
2
Current Issues in Molecular Biology, Год журнала: 2024, Номер 46(11), С. 12196 - 12213
Опубликована: Окт. 30, 2024
Periodontal regeneration is a multifaceted therapeutic approach to restore the tooth-supporting structures lost due periodontal diseases. This manuscript explores intricate interactions between regenerative therapies and oral microbiome, emphasizing critical role of microbial balance in achieving long-term success. While guided tissue (GTR), bone grafting, soft grafting offer promising outcomes terms regeneration, these procedures can inadvertently alter ecosystem, potentially leading dysbiosis or pathogenic recolonization. Different materials, including autografts, allografts, xenografts, alloplasts, influence shifts, with variations healing timeline stabilization. Biologics antimicrobials, such as enamel matrix derivatives (EMD) sub-antimicrobial dose doxycycline (SDD), play key promoting homeostasis by supporting repair reducing bacteria. Emerging strategies, enzyme-based antifouling aim disrupt biofilm formation enhance effectiveness treatments. Understanding dynamics essential for optimizing improving patient outcomes. The future therapy lies development advanced materials strategies that not only tissues but also stabilize ultimately health.
Язык: Английский
Процитировано
2
FEMS Microbes, Год журнала: 2024, Номер 5
Опубликована: Янв. 1, 2024
Abstract The gastrointestinal tract (GIT) is typically considered the natural niche of enterococci. However, these bacteria also inhabit extraintestinal tissues, where they can disrupt organ physiology and cause life-threatening infections. Here, we discuss how enterococci, primarily Enterococcus faecalis, interact with intestine other host anatomical locations such as oral cavity, heart, liver, kidney, vaginal tract. metabolic flexibility allows them to quickly adapt new environments, promoting their persistence in diverse tissues. In transitioning from commensals pathogens, enterococci must overcome harsh conditions nutrient competition, exposure antimicrobials, immune pressure. Therefore, have evolved multiple mechanisms adhere, colonize, persist, endure challenges host. This review provides a comprehensive overview cells tissues across systems, highlighting key molecular pathways that mediate enterococcal adaptation, persistence, pathogenic behavior.
Язык: Английский
Процитировано
1
Nutrients, Год журнала: 2023, Номер 15(23), С. 4900 - 4900
Опубликована: Ноя. 23, 2023
In recent decades, the global demographic landscape has undergone a discernible shift that been characterised by progressive increase in proportion of elderly individuals, indicative an enduring inclination toward extended lifespans. The aging process, accompanied physiological changes and dietary patterns, contributes to detrimental deviations micronutrient consumption. This vulnerable population faces heightened risks, including dental caries, due structural functional modifications resulting from insufficient nutritional sustenance. Factors such as changes, inadequate nutrition, prevalence multiple chronic pathologies leading polypharmacy contribute challenge maintaining optimal status. scenario increases likelihood drug interactions, both between medications with nutrients microbiome, triggering complications decay other pathologies. Since industry is evolving new types food, supplements, are being designed, there need for further research on mechanisms which drugs interfere certain affect homeostasis, exemplified caries mouths older adults. Infectious diseases, among them exert serious impacts health overall quality life demographic. comprehensive review endeavours elucidate intricate interplay drugs, nutrients, oral cavity environment, overarching objective mitigating potential hazards posed general well-being By scrutinising optimising these multifaceted this examination aims proactively minimise susceptibility spectrum health-related issues consequences associated decay.
Язык: Английский
Процитировано
3
Journal of Experimental Biology and Agricultural Sciences, Год журнала: 2024, Номер 12(3), С. 511 - 521
Опубликована: Июль 15, 2024
Periodontal disease, a serious gum infection, is reported to be widespread in the Indian population. A heterogeneous microbial population, predominantly consisting of gram-negative anaerobes such as Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and intermedia, associated with periodontal plaque formation. This condition may worsened by invasion soft tissues different species Candida. Natural products like clove (Syzygium aromaticum) Neem (Azadirachta indica) are very popular easily available climate have great potential preventing periodontitis. Azadirachta indica (Neem) exhibits versatile modes action, including antimicrobial effects against several disease. Therefore, this study aims detect antifungal on oral biofilm both before after Results revealed that neem crude extracts their dilution showed significant reduction growth fungal strains (Candida sp.) isolated from samples people poor hygiene produced them.
Язык: Английский
Процитировано
0