Age-dependent pathogenic profiles of enterotoxigenic Escherichia coli diarrhea in Bangladesh DOI Creative Commons
Marjahan Akhtar, Yasmin Ara Begum, Sadia Rahman

и другие.

Frontiers in Public Health, Год журнала: 2024, Номер 12

Опубликована: Дек. 12, 2024

Background Age plays a significant role in susceptibility to enterotoxigenic Escherichia coli (ETEC) infections, yet the distribution of ETEC virulence factors across age groups remains understudied. This study investigated differential pathogenic profiles various groups, emphasizing importance selecting potential antigens tailored infection patterns infants and adults Bangladesh. Methods utilized icddr,b’s 2% systematic hospital surveillance data diarrheal patients ( n = 14,515) from 2017 2022 examine age-specific pathogenesis clinical manifestations infections. Results In total was identified 1,371 (9.4%) samples. ETEC-associated diarrhea higher children aged 0–2 years decreased significantly 3–17 group. Among all cases, 56% were p 0.0079) with severe dehydration. Distinct toxin types colonization (CFs) observed: heat labile (LT)-associated infections < 0.0001), while stable (ST)-associated-ETEC prevalent ages. Adults exhibited rates strains secreting both toxins. A high prevalence antimicrobial resistance among strains, particularly pediatric observed against commonly used antibiotics such as azithromycin line similar specific profiles. The most common CFs CFA/I, CS3, CS5, CS6, CS21. CFA/I positive more 0.001), CS5 CS6 0.0001). Conclusion findings provide valuable insights into epidemiology, pathogenesis, manifestations. These observations imply that age-related differences host-pathogen interactions exist for this may influence development targeted vaccines or therapeutics use populations.

Язык: Английский

Age-dependent pathogenic profiles of enterotoxigenic Escherichia coli diarrhea in Bangladesh DOI Creative Commons
Marjahan Akhtar, Yasmin Ara Begum, Sadia Rahman

и другие.

Frontiers in Public Health, Год журнала: 2024, Номер 12

Опубликована: Дек. 12, 2024

Background Age plays a significant role in susceptibility to enterotoxigenic Escherichia coli (ETEC) infections, yet the distribution of ETEC virulence factors across age groups remains understudied. This study investigated differential pathogenic profiles various groups, emphasizing importance selecting potential antigens tailored infection patterns infants and adults Bangladesh. Methods utilized icddr,b’s 2% systematic hospital surveillance data diarrheal patients ( n = 14,515) from 2017 2022 examine age-specific pathogenesis clinical manifestations infections. Results In total was identified 1,371 (9.4%) samples. ETEC-associated diarrhea higher children aged 0–2 years decreased significantly 3–17 group. Among all cases, 56% were p 0.0079) with severe dehydration. Distinct toxin types colonization (CFs) observed: heat labile (LT)-associated infections < 0.0001), while stable (ST)-associated-ETEC prevalent ages. Adults exhibited rates strains secreting both toxins. A high prevalence antimicrobial resistance among strains, particularly pediatric observed against commonly used antibiotics such as azithromycin line similar specific profiles. The most common CFs CFA/I, CS3, CS5, CS6, CS21. CFA/I positive more 0.001), CS5 CS6 0.0001). Conclusion findings provide valuable insights into epidemiology, pathogenesis, manifestations. These observations imply that age-related differences host-pathogen interactions exist for this may influence development targeted vaccines or therapeutics use populations.

Язык: Английский

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