Abstract
The
prevalence
of
centenarians,
people
who
lived
100
years
and
longer,
is
steadily
growing
in
the
last
decades.
This
exceptional
longevity
based
on
multifaceted
processes
influenced
by
a
combination
intrinsic
extrinsic
factors
such
as
sex,
(epi-)genetic
factors,
gut
microbiota,
cellular
metabolism,
exposure
to
oxidative
stress,
immune
status,
cardiovascular
risk
environmental
lifestyle
behavior.
Epidemiologically,
incidence
rate
diseases
reduced
healthy
centenarians
along
with
late
onset
age-related
compared
general
aged
population.
Understanding
mechanisms
that
affect
vascular
ageing
underlying
could
offer
valuable
insights
for
developing
strategies
improve
overall
life
span
elderly.
review
discusses
these
key
influencing
how
their
modulation
foster
longevity.
Open Forum Infectious Diseases,
Год журнала:
2024,
Номер
11(10)
Опубликована: Сен. 27, 2024
Central
skull
base
osteomyelitis
(CSBO)
is
an
incompletely
defined,
life-threatening
infection
of
the
bones
cranial
vault.
We
describe
clinical
features
and
outcomes
CSBO
in
Queensland,
Australia,
over
11-year
period.
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 12, 2024
Abstract
Background
A
French
retrospective
observational
cohort
study
conducted
during
the
2021/22
influenza
season
found
that
high-dose
vaccine
(HD)
was
more
effective
than
standard-dose
vaccines
(SDs)
in
preventing
influenza-related
hospitalizations
elderly.
The
continued
2022/23
to
obtain
accurate
results
and
validate
findings
a
different
season.
Material
methods
Data
from
community-dwelling
65+
adults
vaccinated
with
HD
or
SD
vaccination
campaign
were
extracted
National
Health
database.
Hospitalizations
recorded
14
days
after
until
30
June
2023.
recipients
matched
using
propensity
score
an
exact
constraint
on
age,
sex,
week,
geographical
region.
Associations
between
(influenza
non-influenza
related)
assessed
by
estimating
incidence
rate
ratios
converting
them
vs
relative
effectiveness
(rVE).
Results
675,412
2,701,648
recipients.
rVE
for
27.39%
[95%CI:
19.79;34.27].
It
ranged
22.65%
[9.84;33.64]
33.55%
[21.19;43.98]
across
age
groups,
indicating
resulted
consistently
better
protection
SDs
against
all
highest
effect
observed
85+.
Conclusion
Our
is
first
publish
data
comparing
France,
Its
reaffirm
benefit
of
reducing
real-world
setting.
could
help
reduce
burden
severe
respiratory
infections
Registration
number:
Not
applicable.
Highlights
Take-home
message
In
season,
has
reduced
27.4%
compared
among
adults,
clinical
groups.
Historical
survey
confirms
that,
over
the
latter
part
of
20th
century,
autoimmune-based
diseases,
including
multiple
sclerosis
(MS),
have
shown
a
worldwide
increase
in
incidence
and
prevalence.
Analytical
population
studies
established
that
exponential
rise
MS
is
not
solely
due
to
improvements
diagnosis
healthcare
but
relates
an
autoimmune
risk
factors.
Harmful
environmental
exposures,
non-communicable
social
determinants
health,
anthropogens
indigenous
or
transmissible
microbes,
constitute
group
causal
been
closely
linked
with
global
cases.
Exposure
stressors
has
profound
effects
on
adaptive
arm
immune
system
and,
particular,
associated
intrinsic
process
ageing
immunosenescence
(ISC).
Stressor-related
disturbances
dynamics
ISC
include
cell-linked
untimely
premature
(p)
alterations
accelerated
replicative
(ar)
change.
A
recognised
immune-associated
feature
pISC
current
evidence
supports
presence
arISC
during
disease.
Moreover,
collated
data
illustrates
characterise
are
inducible
by
strongly
implicated
causing
duplicate
changes
cells
MS.
The
close
relationship
between
exposure
factors
induction
offers
valid
mechanism
through
which
pro-immunosenescent
may
act
contribute
recorded
rate
number
new
cases
Confirmation
provides
rational
valuable
therapeutic
target
for
use
senolytic
drugs
either
prevent
accumulation
enhance
ablation
less
efficient
senescent
decelerate
dysregulated
proliferation.
range
senotherapeutics
available
kinase
transcriptase
inhibitors,
rapalogs,
flavanols
genetically-engineered
T
selective
treatments
control
emerging
unspecified
aspects
discussed.
Abstract
The
prevalence
of
centenarians,
people
who
lived
100
years
and
longer,
is
steadily
growing
in
the
last
decades.
This
exceptional
longevity
based
on
multifaceted
processes
influenced
by
a
combination
intrinsic
extrinsic
factors
such
as
sex,
(epi-)genetic
factors,
gut
microbiota,
cellular
metabolism,
exposure
to
oxidative
stress,
immune
status,
cardiovascular
risk
environmental
lifestyle
behavior.
Epidemiologically,
incidence
rate
diseases
reduced
healthy
centenarians
along
with
late
onset
age-related
compared
general
aged
population.
Understanding
mechanisms
that
affect
vascular
ageing
underlying
could
offer
valuable
insights
for
developing
strategies
improve
overall
life
span
elderly.
review
discusses
these
key
influencing
how
their
modulation
foster
longevity.
