Food Bioscience, Год журнала: 2024, Номер 63, С. 105628 - 105628
Опубликована: Дек. 8, 2024
Язык: Английский
Life, Год журнала: 2024, Номер 14(10), С. 1234 - 1234
Опубликована: Сен. 26, 2024
Microbes have inhabited the earth for hundreds of millions years longer than humans. The microbiota-gut-brain axis (MGBA) represents a bidirectional communication pathway. These communications occur between central nervous system (CNS), enteric (ENS), and emotional cognitive centres brain. field research on gut-brain has grown significantly during past two decades. Signalling occurs gut microbiota brain through neural, endocrine, immune, humoral pathways. A substantial body evidence indicates that MGBA plays pivotal role in various neurological diseases. include Alzheimer's disease (AD), autism spectrum disorder (ASD), Rett syndrome, attention deficit hyperactivity (ADHD), non-Alzheimer's neurodegeneration dementias, fronto-temporal lobe dementia (FTLD), Wilson-Konovalov (WD), multisystem atrophy (MSA), Huntington's chorea (HC), Parkinson's (PD), multiple sclerosis (MS), amyotrophic lateral (ALS), temporal epilepsy (TLE), depression, schizophrenia (SCZ). Furthermore, correlation therapeutics will be discussed. Conversely, mood delivery, exercise, psychotropic agents, stress, neurologic drugs can influence MGBA. By understanding MGBA, it may possible to facilitate into microbial-based interventions therapeutic strategies
Язык: Английский
Процитировано
8
Frontiers in Cellular and Infection Microbiology, Год журнала: 2025, Номер 14
Опубликована: Янв. 6, 2025
Breast milk is an essential source of infant nutrition. It also a vital determinant the structure and function intestinal microbial community, it connects mother microbiota. Human oligosaccharides (HMOs) are critical component in breast milk. HMOs can reach baby's colon entirely from become fermentable substrate for some microorganisms. enhance mucosal barrier affect host through immune function, which has therapeutic effect on specific diseases, such as necrotizing enterocolitis. In addition, changes microbiota reflect maternal link between infants related to Through breastfeeding, jointly bacteria. Therefore, positively influence establishment balance ensure function. be used supplement alternative therapy diseases.
Язык: Английский
Процитировано
1
Nutrients, Год журнала: 2025, Номер 17(3), С. 519 - 519
Опубликована: Янв. 30, 2025
The purpose of this study was to investigate the degradation mechanism Bifidobacterium on breast milk oligosaccharides (HMOs) and its application in infant nutrition. composition characteristics HMOs were introduced, by described, including intracellular extracellular digestion species-specific differences. interaction between Bacteroides process degrading effect intestinal microecology analyzed. effects HMO formula powder microbiota infants discussed, simulating composition, regulating flora immune function, infection prevention, brain development. Finally, research results are summarized, future directions proposed provide for field
Язык: Английский
Процитировано
0
eFood, Год журнала: 2025, Номер 6(1)
Опубликована: Фев. 1, 2025
ABSTRACT Short‐chain carbohydrates are primarily made up of fructose molecules; fructooligosaccharides (FOS) referred to as prebiotics and renowned for their potential beneficial effects on health. Since they inedible fibers, FOS go through the upper digestive tract nearly undisturbed while entering colon, where offer food gut bacteria, such Lactobacilli Bifidobacteria . This method supports health improves immunity by maintaining an optimal microbiome. Based studies, establishing environment, can reduce risk several disorders, particularly inflammatory bowel disease (IBD), constipation, irritable syndrome (IBS). has shown improving metabolic along with They help regulate weight diabetes due low caloric content ability blood glucose levels. review will contribute development more focused effective applications in medicine identifying areas research gaps suggesting future directions.
Язык: Английский
Процитировано
0
Deleted Journal, Год журнала: 2025, Номер 4(1), С. 8 - 22
Опубликована: Фев. 28, 2025
Background: Malnutrition remains a critical global health concern, with both short- and long-term consequences. Children suffering from malnutrition frequently exhibit gut dysfunction, which leads to growth retardation, impaired absorption of essential nutrients vitamins, immune dysfunction. Diarrhea is one the most common conditions in children can further worsen their condition. Probiotics have been proposed as potential adjunctive therapy due role modulating microbiota. This study aims evaluate effects probiotics on weight gain diarrhea specifically severe acute (SAM). Methods: A systematic literature search was conducted across six databases (PubMed, Cochrane Library, ProQuest, EBSCOhost, ScienceDirect, Google Scholar) using relevant keywords. Data were extracted analyzed Review Manager for meta-analysis. Result: Four studies, encompassing total 1662 patient met inclusion criteria. are proven reduce significantly duration improve recovery (SMD -0.70; 95% CI -0.89 -0.50; I² = 0%, p < 0.00001). However, they not diminishing incidence diarrhea. Moreover, this concluded that use or synbiotics did impact gain. Conclusion: demonstrated efficacy reducing diarrhea, but its incidence, potentially contributing improved outcomes. SAM inconclusive. Further research larger studies warranted identify factors influencing probiotic explore comprehensive management SAM.
Язык: Английский
Процитировано
0
World Journal of Clinical Pediatrics, Год журнала: 2025, Номер 14(2)
Опубликована: Март 18, 2025
BACKGROUND Human milk oligosaccharides (HMOs) are bioactive components of breast with diverse health benefits, including shaping the gut microbiota, modulating immune system, and protecting against infections. HMOs exhibit dynamic secretion patterns during lactation, influenced by maternal genetics environmental factors. Their direct indirect antimicrobial properties have garnered significant research interest. However, a comprehensive understanding dynamics their correlation efficacy remains underexplored. AIM To synthesize current evidence on lactation evaluate roles bacterial, viral, protozoal pathogens. METHODS A systematic search PubMed, Scopus, Web Science, Cochrane Library focused studies investigating natural synthetic HMOs, dynamics, properties. Studies involving human, animal, in vitro models were included. Data HMO composition, temporal patterns, mechanisms action extracted. Quality assessment was performed using validated tools appropriate for study design. RESULTS total 44 included, encompassing research. exhibited 2′-fucosyllactose (2′-FL) lacto-N-tetraose peaking early declining over time, while 3-fucosyllactose (3-FL) increased later stages. demonstrated through pathogen adhesion inhibition, biofilm disruption, enzymatic activity impairment. Synthetic bioengineered 2′-FL 3-FL, structurally functionally comparable to effectively inhibiting pathogens such as Pseudomonas aeruginosa , Escherichia coli Campylobacter jejuni . Additionally, synergistic effects antibiotics, enhancing resistant CONCLUSION vital defense, supporting infant targeting various Both hold potential therapeutic applications, particularly nutrition adjuncts antibiotics. Further research, clinical trials, is essential address gaps knowledge, validate findings, explore broader applicability improving neonatal health.
Язык: Английский
Процитировано
0
Nutrients, Год журнала: 2025, Номер 17(6), С. 1068 - 1068
Опубликована: Март 19, 2025
The issue of antibiotic-resistant bacterial infections, coupled with the rise in viral pandemics and slow development new antibacterial antiviral treatments, underscores critical need for novel strategies to mitigate spread drug-resistant pathogens, enhance efficacy existing therapies, accelerate discovery deployment innovative antimicrobial solutions. One promising approach address these challenges is dietary supplementation non-digestible oligosaccharides (NDOs). NDOs, including human milk (HMOs), play a vital role shaping sustaining healthy gut microbiota. Beyond stimulating growth activity beneficial bacteria, NDOs can also interact directly pathogenic bacteria viruses. Their properties arise from their unique interactions pathogens ability modulate host’s immune system. function as decoy receptors, inhibit pathogen growth, bind toxins, stimulate host response, exhibit anti-biofilm properties, barrier protection. However, notable gap exists comprehensive assessment vivo clinical data on this topic. This review aims provide an in-depth overview evidence related effects various HMOs, focus discussing possible mechanisms action.
Язык: Английский
Процитировано
0
Nutrients, Год журнала: 2024, Номер 16(21), С. 3706 - 3706
Опубликована: Окт. 30, 2024
: This review investigates the impact of bioactive molecules produced by probiotics on child health, focusing their roles in modulating gut microbiota, enhancing immune function, and supporting overall development. Key metabolites, including short-chain fatty acids (SCFAs), bacteriocins, exopolysaccharides (EPSs), vitamins, gamma-aminobutyric acid (GABA), are highlighted for ability to maintain regulate inflammation, support neurodevelopment.
Язык: Английский
Процитировано
3
Nutrients, Год журнала: 2024, Номер 16(20), С. 3510 - 3510
Опубликована: Окт. 16, 2024
Background: the intestinal microbiota, a complex community vital to human health, is shaped by microbial competition and host-driven selective pressures. Among these microbes, Bifidobacterium plays crucial role in early gut colonization during neonatal stages, where longum subspecies infantis (B. infantis) predominates particularly prevalent healthy breastfed infants. Objectives: as we embark on new era nutrition of pediatric population, this study seeks examine existing understanding regarding B. infantis, encompassing both preclinical insights clinical evidence. Methods: through narrative disceptation current literature, focus its genetic capacity break down various substances that support survival dominance intestine. Results: using “omics” technologies, researchers have identified beneficial mechanisms including production short-chain fatty acids, serine protease inhibitors, polysaccharides. While declines with age diseases, it remains widely used probiotic documented benefits for infant child health numerous studies. Conclusions: scientific evidence underscores importance ongoing research trials deeper infantis’s promoting long-term health.
Язык: Английский
Процитировано
1
Food Bioscience, Год журнала: 2024, Номер 61, С. 104957 - 104957
Опубликована: Авг. 20, 2024
Язык: Английский
Процитировано
0