Risk prediction models for dysphagia after radiotherapy among patients with head and neck cancer: a systematic review and meta-analysis
Frontiers in Oncology,
Год журнала:
2025,
Номер
15
Опубликована: Фев. 7, 2025
Background
Predictive
models
can
identify
patients
at
risk
and
thus
enable
personalized
interventions.
Despite
the
increasing
number
of
prediction
used
to
predict
dysphagia
after
radiotherapy
in
with
head
neck
cancer
(HNC),
there
is
still
uncertainty
about
effectiveness
these
clinical
practice
quality
applicability
future
studies.
The
aim
this
study
was
systematically
evaluate
analyze
all
predictive
HNC
radiotherapy.
Methods
PubMed,
Cochrane
Library,
EMbase
Web
Science
databases
were
searched
from
database
establishment
August
31,
2024.
Data
selected
studies
extracted
using
predefined
tables
modelling
assessed
PROBAST
tool.
Meta-analysis
performance
model
performed
“metafor”
package
R
software.
Results
Twenty-five
predicting
included,
covering
a
total
8,024
patients.
Common
predictors
include
mean
dose
pharyngeal
constrictor
muscles,
treatment
setting,
tumor
site.
Of
models,
most
constructed
based
on
logistic
regression,
while
only
two
machine
learning
methods.
area
under
receiver
operating
characteristic
curve
(AUC)
reported
values
for
ranged
0.57
0.909,
13
having
combined
AUC
value
0.78
(95%
CI:
0.74-0.81).
All
showed
high
bias
as
by
Conclusion
Most
published
have
good
discrimination.
However,
considered
assessments.
Future
should
focus
large
sample
size
rigorously
designed
multicenter
external
validation
improve
reliability
HNC.
Systematic
review
registration
https://www.crd.york.ac.uk/prospero
,
identifier
CRD42024587252.
Язык: Английский
Exploring anticancer potential of betanin in DMBA-induced oral squamous cell carcinoma: an in silico and experimental study
Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 26, 2025
Язык: Английский
Therapeutic Potential of Phytochemicals as Adjuvants in Head and Neck Cancer
Mahesh C. Kaushik,
Ashu Bhan Tiku
Nutrition Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 19, 2025
Abstract
Owing
to
the
developments
in
various
therapeutic
modalities,
cancer
treatment
has
come
a
long
way,
including
discovery
of
anticancer
drugs,
innovations
delivery
technology,
and
increased
personalization
treatments.
Despite
this,
head
neck
(HNC)
is
that
eluded
current
conventional
To
improve
quality
life
preserve
vital
organ
function
patients
with
HNC,
there
need
for
research
into
regimes
would
reduce
toxicity
modalities.
The
use
single
approach
not
been
enough
completely
eradicate
this
malignancy.
Therefore,
adjuvants
combinatorial
approaches,
using
molecules
from
natural
compounds
have
no
or
minimal
side
effects,
growing
area
research.
One
objective
review
was
clarify
potentiality
novel
strategies
such
as
phytochemicals
chemotherapy
radiotherapy,
nano-formulation
delivery.
Another
delineate
associated
challenges
clinical
application
these
therapies
HNC.
Possible
overcoming
critical
issues
HNC
are
also
discussed.
Язык: Английский
Neuregulin-Induced HER3 Activation Drives Migration in Head and Neck squamous cell carcinoma via HER2 and FAK Signaling Pathways
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 3, 2025
Abstract
Purpose
To
investigate
the
role
of
neuregulin
(NRG)
signaling
in
promoting
head
and
neck
squamous
cell
carcinoma
(HNSCC)
migration
through
HER3-dependent
pathways
to
assess
therapeutic
potential
targeting
NRG/HER3
axis
mitigating
perineural
invasion.
Methods
NRG-driven
was
studied
using
DRG
co-culture,
wound
healing
assays,
HER3
inhibition
(shRNA,
AV-203).
The
biological
function
biochemical
effects
HER3/HER2/FAK
response
NRG
were
analyzed
via
phosphorylation
knockdown,
western
blotting,
staining
for
protein
expression.
Results
promoted
directional
FaDu
TU138
HNSCC
cells
HER3/HER2
HER3/PI3K
interactions.
(shRNA
or
AV-203)
abolished
phosphorylation,
disrupted
HER3-HER2
interactions,
suppressed
AKT
ERK
signaling.
Wound
assays
confirmed
that
enhances
activation.
also
induced
FAK
knockdown
with
PF228
significantly
reduced
migration,
highlighting
critical
HER3-FAK
Conclusion
promotes
by
activating
HER3,
forming
complexes,
driving
downstream
AKT,
ERK,
Targeting
holds
as
a
strategy
address
invasion
associated
clinical
challenges
HNC.
Язык: Английский
Association between human herpesviruses and head and neck squamous cell carcinoma: a molecular perspective
Annals of Saudi Medicine,
Год журнала:
2025,
Номер
45(2), С. 104 - 111
Опубликована: Март 1, 2025
BACKGROUND:
Head
and
neck
cancer
(HNC)
is
the
seventh
most
common
malignant
tumor.
Herpesviruses
are
a
significant
risk
factor
in
multifactorial
pathogenesis
of
HNC.
OBJECTIVES:
This
study
aimed
to
investigate
association
between
herpesviruses
development
head
squamous
cell
carcinoma
(HN-SCC).
DESIGN:
Experimental
SETTING:
A
university
hospital
Turkey
PATIENTS
AND
METHODS:
Pathological
archive
tissue
samples
500
patients
were
included
study.
These
categorized
into
two
groups:
those
diagnosed
with
HN-SCC
(n=300,
group
[MG])
benign
lesions
(n=200,
[BG]).
The
presence
herpesvirus
was
detected
using
polymerase
chain
reaction.
MAIN
OUTCOME
MEASURES:
Association
cancer.
SAMPLE
SIZE:
RESULTS:
HHV-1,
-2,
-7,
-8
not
any
samples.
In
(MG),
EBV-DNA
1
patient
(0.3%)
HHV-6
DNA
2
(0.6%),
while
(BG),
VZV-DNA
(0.5%),
3
(1.5%),
CMV-DNA
5
(2.5%),
(1.5%).
While
no
difference
found
groups
for
VZV,
EBV,
HHV-6,
statistically
favor
CMV.
CONCLUSION:
Although
seroprevalence
relatively
high
population,
lack
viral
genome
indicates
that
other
factors
might
be
prominent
developing
HN-SCC.
LIMITATION:
storage
conditions
sample
used
(paraffinized
sample)
may
have
negatively
affected
detection
frequency
HHVs.
Язык: Английский
The viral oncogenesis of COVID-19 and its impact on cancer progression, long-term risks, treatment complexities, and research strategies
Exploration of Medicine,
Год журнала:
2025,
Номер
6
Опубликована: Апрель 28, 2025
The
interaction
between
cancer
and
coronavirus
disease
2019
(COVID-19)
poses
significant
challenges,
particularly
for
immunocompromised
individuals
who
are
at
heightened
risk
acute
infections
long-term
complications.
pandemic
has
exacerbated
existing
vulnerabilities
in
care
by
disrupting
treatment
protocols
delaying
diagnoses,
leading
to
worsened
health
outcomes.
This
article
emphasizes
the
importance
of
investigating
potential
impact
severe
respiratory
syndrome
2
(SARS-CoV-2)
on
progression
highlights
need
effective
strategies
protect
this
high-risk
population.
Long-term
consequences,
including
emergence
long
COVID,
further
emphasize
ongoing
surveillance
comprehensive
healthcare
planning
patients
during
after
pandemics.
A
multifaceted
approach
is
essential,
incorporating
vaccination,
timely
therapeutic
interventions,
sustained
support
with
lingering
symptoms.
also
discusses
urges
continued
research
into
oncogenic
risks
associated
SARS-CoV-2,
which
crucial
enhancing
our
understanding
broader
implications
COVID-19
informing
public
aimed
safeguarding
future
Moreover,
data
collection
development
refined
clinical
guidelines
vital
improving
patient
outcomes
preparing
systems
crises.
Additionally,
mechanisms
SARS-CoV-2
may
increase
susceptibility,
chronic
inflammation,
cellular
senescence,
immune
dysregulation.
Understanding
these
elucidating
virus’s
potential,
among
survivors
infections.
Ensuring
continuity
resilience
global
crises
requires
mitigate
disruptions,
enhance
access
screenings
treatments,
address
specific
challenges
faced
experiencing
COVID.
Язык: Английский
Neuregulin-induced HER3 activation drives migration in head and neck squamous cell carcinoma via HER2 and FAK signaling pathways
Cellular Oncology,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 12, 2025
Язык: Английский
Multifaceted Evaluation of Inhibitors of Anti-Apoptotic Proteins in Head and Neck Cancer: Insights from In Vitro, In Vivo, and Clinical Studies (Review)
Pharmaceuticals,
Год журнала:
2024,
Номер
17(10), С. 1308 - 1308
Опубликована: Сен. 30, 2024
This
paper
presents
a
multifaceted
assessment
of
inhibitors
anti-apoptotic
proteins
(IAPs)
in
the
context
head
and
neck
squamous
cell
carcinoma
(HNSCC).
The
article
discusses
results
vitro,
vivo,
clinical
studies,
highlighting
significance
IAPs
resistance
cancer
cells
to
apoptosis,
which
is
key
factor
hindering
effective
treatment.
main
apoptosis
pathways,
including
intrinsic
extrinsic
role
their
regulation,
are
presented.
study's
findings
suggest
that
targeting
with
novel
therapies
may
offer
benefits
treatment
advanced
HNSCC,
especially
cases
resistant
conventional
methods.
These
conclusions
underscore
need
for
further
research
develop
more
safer
therapeutic
strategies.
Язык: Английский
Pathogenetic Action of Viruses in Head and Neck Cancer
IntechOpen eBooks,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 16, 2024
Head
and
neck
cancer
(HNC)
represents
a
heterogeneous
group
of
neoplasms
with
different
biological
clinical
behavior,
which
develops
in
the
upper
parts
respiratory
digestive
tract
outside
esophagus.
The
majority
(>90%)
HNCs
arise
from
squamous
epithelium
are
classified
as
head
cell
carcinomas
(HNSCCs).
main
anatomical
localizations
HNSCCs
concern
paranasal
sinuses,
oral
cavity,
salivary
glands,
larynx,
pharynx,
nasal
cavity.
Oncogenic
viruses
play
an
important
role
development
HNC.
Human
papillomavirus
(HPV)
has
been
extensively
studied
relation
to
oropharyngeal
carcinoma,
but
other
oncogenic
also
contribute
HNC
onset.
This
chapter
summarizes
advances
pathogenesis,
epidemiology
detection
implicated
HNC,
recognizing
established
HPV
discussing
its
relationship
viruses.
Epstein-Barr
virus
particular
associated
lymphoma
nasopharyngeal
carcinoma.
Merkel
polyomavirus
subset
human
herpesvirus
8
is
linked
Kaposi
sarcoma.
Hepatitis
have
investigated
for
possible
association
Язык: Английский