Evaluation of antiobesogenic properties of fermented foods: In silico insights
Journal of Food Science,
Год журнала:
2025,
Номер
90(3)
Опубликована: Март 1, 2025
Obesity
prevalence
has
steadily
increased
over
the
past
decades.
Standard
approaches,
such
as
energy
expenditure,
lifestyle
changes,
a
balanced
diet,
and
use
of
specific
drugs,
are
conventional
strategies
for
preventing
or
treating
disease
its
associated
complications.
Fermented
foods
their
subsequent
bioactive
constituents
now
believed
to
be
novel
strategy
that
can
complement
already
existing
approaches
managing
this
disease.
Recent
developments
in
systems
biology
bioinformatics
have
made
it
possible
model
simulate
compounds
interactions.
The
adoption
silico
models
contributed
discovery
fermented
product
targets
helped
testing
hypotheses
regarding
mechanistic
impact
underlying
functions
food
components.
From
studies
explored,
key
findings
suggest
affect
adipogenesis,
lipid
metabolism,
appetite
regulation,
gut
microbiota
composition,
insulin
resistance,
inflammation
related
obesity,
which
could
lead
new
ways
treat
these
conditions.
These
outcomes
were
linked
probiotics,
prebiotics,
metabolites,
complex
substances
produced
during
fermentation.
Overall,
show
promise
innovative
tools
obesity
management
by
influencing
metabolic
pathways
overall
health.
Язык: Английский
Gut Mycobiome: Latest Findings and Current Knowledge Regarding Its Significance in Human Health and Disease
Journal of Fungi,
Год журнала:
2025,
Номер
11(5), С. 333 - 333
Опубликована: Апрель 22, 2025
The
gut
mycobiome,
the
fungal
component
of
microbiota,
plays
a
crucial
role
in
health
and
disease.
Although
fungi
represent
small
fraction
ecosystem,
they
influence
immune
responses,
homeostasis,
disease
progression.
mycobiome’s
composition
varies
with
age,
diet,
host
factors,
its
imbalance
has
been
linked
to
conditions
such
as
inflammatory
bowel
(IBD)
metabolic
disorders.
Advances
sequencing
have
expanded
our
understanding
fungi,
but
challenges
remain
due
methodological
limitations
high
variability
between
individuals.
Emerging
therapeutic
strategies,
including
antifungals,
probiotics,
fecal
microbiota
transplantation,
dietary
interventions,
show
promise
require
further
study.
This
review
highlights
recent
discoveries
on
interactions
bacteria,
disease,
potential
clinical
applications.
A
deeper
contributions
will
help
develop
targeted
microbiome-based
therapies.
Язык: Английский
The Role of Plant-Based Nutrition and Exercise in Metabolic Syndrome: A Narrative Review
Nutrients,
Год журнала:
2025,
Номер
17(9), С. 1498 - 1498
Опубликована: Апрель 29, 2025
Metabolic
syndrome
(MetS)
is
a
prevalent
health
condition
characterized
by
central
obesity,
insulin
resistance,
hypertension,
and
dyslipidemia,
increasing
the
risk
of
cardiovascular
disease
type
2
diabetes.
Lifestyle
interventions,
particularly
plant-based
nutrition
exercise,
are
essential
for
managing
MetS.
While
both
strategies
well-documented
independently,
their
synergistic
effects
remain
less
explored.
This
narrative
review
integrates
findings
from
domains
to
evaluate
combined
impact
on
metabolic
syndrome.
The
examines
individual
impacts
exercise
MetS-related
dysfunction.
A
comprehensive
114
peer-reviewed
studies
was
conducted
assess
role
diets
structured
physical
activity
in
improving
sensitivity,
lipid
profiles,
inflammation,
weight
management.
Studies
investigating
mechanisms
through
which
dietary
components
modalities
influence
were
analyzed,
along
with
behavioral
psychological
factors
affecting
long-term
adherence.
Plant-based
diets,
those
high
fiber,
polyphenols,
healthy
fats,
improve
glucose
metabolism,
reduce
enhance
health.
Exercise
complements
these
benefits
promoting
fat
oxidation,
metabolism.
When
combined,
provide
superior
outcomes,
including
greater
reductions
visceral
adiposity,
improved
endothelial
function,
enhanced
glycemic
control.
effective
Their
highlight
importance
integrated
lifestyle
interventions
Язык: Английский
Supporting Neurologic Health with Mushroom Nutrition
Nutrients,
Год журнала:
2025,
Номер
17(9), С. 1568 - 1568
Опубликована: Май 2, 2025
Due
to
the
extensive
types
of
etiologies
and
risks
causing
over
600
mental
health
issues,
convene
adequate
recommendations
in
primary
care
is
a
difficult
assignment.
The
starting
point
for
preventive
interventions
on
neurologic
disorders
involves
scrutinizing
risk
factors
while
targeting
multiple
hazards
order
increase
success
an
early
precautionary
mediation
plan
action.
factor
most
neurodegenerative
diseases
increasing
worldwide
median
age,
although
one
seven
youngsters
also
experience
disability,
namely
depression,
representing
decline
well-being
conferring
considerable
global
public
challenge.
brain
operates
optimally
when
supported
by
holistic
approach
engaging
several
aspects,
diet
becoming
integral
part
strategies.
Treatment
presently
dominated
pharmacotherapy,
but
additional
strategies
are
needed
prevent
treat
disorders.
Dietary
modification
can
prove
be
cost-effective
strategy
prevention
and,
certain
conditions,
treatment
neurological
Molecules
dietary
ingredients,
micronutrients,
phytonutrients,
additives
may
modulate
depression
associated
biomarkers.
Nutritional
exposure
during
developmental
stages
maternal
impact,
lifestyles,
modulation
gut
microbiota
through
as
novel
therapies
various
neuropsychiatric
conditions
gaining
interest
maintaining
health.
Bioactive
substances
present
different
mushroom
species
have
been
ascribed
both
direct
indirect
mechanisms
influence
neurobehavior,
here
we
support
recognition
nutrition
influential
element
management
some
concerns.
Scientific
evidence
demonstrating
unequivocal
link
between
nutritional
mushrooms
cognitive
only
beginning
emerge,
medicine
should
considered
care.
Язык: Английский
Impacts of dietary different levels of thyme leave powder as a natural growth promoter on growth performance, carcass characteristics, and blood indices of broilers
Poultry Science,
Год журнала:
2024,
Номер
103(12), С. 104396 - 104396
Опубликована: Окт. 10, 2024
The
objective
of
the
present
study
was
to
ascertain
influence
thyme
leaf
powder
(TLP)
on
growth
rate,
carcass
features,
and
blood
indicators
in
broiler
diets
as
a
natural
antioxidant
antibiotic
substitute.
A
fully
randomized
design
experiment
divided
264-day-old
chicks
(Ross
308)
into
4
experimental
groups.
Six
replicates
each
group,
containing
11
unsexed
chicks,
were
created.
following
therapies:
control
group
without
additive
(basal
diet);
TLP1,
TLP2
TLP3:
basal
diet
+
1,
2
3
g
leaves
powder/kg
diet,
respectively.
Results
showed
that
TLP
added
at
or
g/kg
feed
significantly
enhanced
body
weight
gain
(except
for
period
from
16
30
d
life),
intake
1
15
conversion
ratio
throughout
period.
Furthermore,
there
significant
decrease
creatinine
alanine
aminotransferase
(ALT)
with
different
levels,
particularly
TLP/kg
diet.
Compared
birds'
included
highest
levels
albumin
total
protein
A/G
(albumin/globulin)
ratio.
birds
fed
had
lowest
concentrations
low-density
lipoprotein
(LDL)
cholesterol
(TC).
Moreover,
all
treatment
higher
IgY
than
group.
Nevertheless,
including
IgM
levels.
Additionally,
superoxide
dismutase
activity
(SOD)
1g
minimum
Notably,
malondialdehyde
(MDA)
maximum
meal
TLP/kg.
We
may
conclude
using
increases
immunity,
productivity,
overall
health,
especially
level
Язык: Английский
Diet Impacts on Gene Expression in Healthy Colon Tissue: Insights from the BarcUVa-Seq Study
Nutrients,
Год журнала:
2024,
Номер
16(18), С. 3131 - 3131
Опубликована: Сен. 16, 2024
(1)
Introduction:
The
global
rise
of
gastrointestinal
diseases,
including
colorectal
cancer
and
inflammatory
bowel
highlights
the
need
to
understand
their
causes.
Diet
is
a
common
risk
factor
crucial
regulator
gene
expression,
with
alterations
observed
in
both
conditions.
This
study
aims
elucidate
specific
biological
mechanisms
through
which
diet
influences
diseases.
(2)
Methods:
We
analyzed
data
from
436
participants
BarcUVa-Seq
population-based
cross-sectional
utilizing
expression
profiles
(RNA-Seq)
frozen
colonic
mucosal
biopsies
dietary
information
semi-quantitative
food
frequency
questionnaire.
Dietary
variables
were
evaluated
based
on
two
patterns
as
individual
variables.
Differential
(DEG)
analysis
was
performed
for
each
using
edgeR.
Protein-protein
interaction
(PPI)
conducted
STRINGdb
v11
groups
more
than
10
statistically
significant
DEGs,
followed
by
Reactome-based
enrichment
resulting
networks.
(3)
Results:
Our
findings
reveal
that
intake,
specifically
consumption
blue
fish,
alcohol,
potatoes,
significantly
colon
individuals
without
tumor
pathology,
particularly
pathways
related
DNA
repair,
immune
system
function,
protein
glycosylation.
(4)
Discussion:
These
results
demonstrate
how
these
components
may
influence
human
metabolic
processes
affect
Язык: Английский