Drug Clues for the Treatment of Fungal Catheter-Related Bloodstream Infection With Antifungal Lock Therapy DOI Creative Commons
Xiuyun Li, Bing Yu, Hui Li

и другие.

Drug Design Development and Therapy, Год журнала: 2025, Номер Volume 19, С. 683 - 701

Опубликована: Янв. 1, 2025

Biofilm formation often represents significant challenges in managing of bloodstream infections associated with catheter use. Antimicrobial lock therapy serves as an adjunctive treatment for catheter-related infections, effectively eradicating or inhibiting biofilm growth. This review synthesizes the current knowledge on antifungal (ALT) targeting clinically common fungi, primarily Candida species, based both vitro and vivo studies (animals patients) from past decade. Amphotericin B (AmB) echinocandins are identified most promising agents ALT. Combinations other compounds, such farnesol, Neosartorya fischeri protein 2, 8-hydroxyquinoline-5-(N-4-chlorophenyl) sulfonamide, polyurethane, have also shown efficacy Additionally, ethanol, doxycycline, tigecycline, minocycline solutions can be effective treating fungal infections. More comprehensive investigations additional rigorous clinical trials essential to thoroughly understand safety will facilitate development novel treatments thereby improving outcomes.

Язык: Английский

Drug Clues for the Treatment of Fungal Catheter-Related Bloodstream Infection With Antifungal Lock Therapy DOI Creative Commons
Xiuyun Li, Bing Yu, Hui Li

и другие.

Drug Design Development and Therapy, Год журнала: 2025, Номер Volume 19, С. 683 - 701

Опубликована: Янв. 1, 2025

Biofilm formation often represents significant challenges in managing of bloodstream infections associated with catheter use. Antimicrobial lock therapy serves as an adjunctive treatment for catheter-related infections, effectively eradicating or inhibiting biofilm growth. This review synthesizes the current knowledge on antifungal (ALT) targeting clinically common fungi, primarily Candida species, based both vitro and vivo studies (animals patients) from past decade. Amphotericin B (AmB) echinocandins are identified most promising agents ALT. Combinations other compounds, such farnesol, Neosartorya fischeri protein 2, 8-hydroxyquinoline-5-(N-4-chlorophenyl) sulfonamide, polyurethane, have also shown efficacy Additionally, ethanol, doxycycline, tigecycline, minocycline solutions can be effective treating fungal infections. More comprehensive investigations additional rigorous clinical trials essential to thoroughly understand safety will facilitate development novel treatments thereby improving outcomes.

Язык: Английский

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