Dietary Trials and Gut Candidate Phyla Radiation Bacteria: The Effect of Placebo on the Prevalence of Saccharibacteria in Healthy Armenian Women and Women with Familial Mediterranean Fever DOI
Natalya Harutyunyan, Lena Stepanyan, Lena Malkhasyan

и другие.

AgriScience and Technology, Год журнала: 2024, Номер unknown, С. 345 - 353

Опубликована: Янв. 1, 2024

“Candidate Phyla Radiation” (CPR) bacteria, representing ~15 % of bacterial diversity and over 70 phyla, are extremely small bacteria that primarily survive in parasitic or symbiotic forms. CPR including Candidatus Brownbacteria, Hugbacteria, Saccharibacteria (formerly TM7), were first identified humans 2007. They linked to the microbiota healthy diseased individuals, being present oral cavity, gastrointestinal, reproductive tracts. such as Saccharibacteria, associated with dysbiotic conditions like periodontitis can act pathogens potential protectors against inflammatory damage caused by host-associated bacteria.This study aimed assess effect a placebo on gut Armenian women those Familial Mediterranean Fever (FMF) disease, condition high prevalence Armenia often disturbances. Stool samples analyzed using culture-independent, high-density DNA microarray method, statistical analyses performed Multibase 2015 Excel Add-in program (NumericalDynamics, Tokyo, Japan). Results indicate respond variably depending health status, some showing significant quantitative qualitative changes while others remained unchanged. In conclusion, this confirms presence both FMF. The distinct responses intestinal highlight importance placebo-controlled trials research. Furthermore, findings emphasize role gut-brain processes their implications disease.

Язык: Английский

Mitochondrial Dysfunction and Atherosclerosis: The Problem and the Search for Its Solution DOI Creative Commons
Ганна Володимирівна Невойт, Gediminas Jaruševičius, М. M. Potyazhenko

и другие.

Biomedicines, Год журнала: 2025, Номер 13(4), С. 963 - 963

Опубликована: Апрель 15, 2025

Background/Objectives: This review has been prepared to promote interest in the interdisciplinary study of mitochondrial dysfunction (MD) and atherosclerosis. aims describe state this problem indicate direction for further implementation knowledge clinical medicine. Methods: Extensive research literature was implemented elucidate role molecular mechanisms MD pathogenesis Results: A view on atherosclerosis through prism about is presented. cause primary mechanism onset progression It proposed that be considered context a continuum. Conclusions: are united by common pathogenesis. Knowledge should used argue healthy lifestyle as way prevent The development new approaches diagnosing treating an urgent task challenge modern science.

Язык: Английский

Процитировано

0
Impact of Dietary Antioxidants on Redox Homeostasis and Its Effects on Health and Disease DOI
Reyed M Reyed, Pranav Kumar Prabhakar

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Год журнала: 2025, Номер unknown, С. 81 - 136

Опубликована: Янв. 3, 2025

This chapter discusses the roles of reactive oxygen species (ROS) in cells, including their role oxidative stress and redox balance. It explores how dietary antioxidants affect homeostasis, sources, mechanisms action, antioxidant capacity. The also ROS-mediated signaling cascades endogenous defense mechanisms. use pharmacological approaches to treat chronic illnesses like cancer, neurological disorders, cardiometabolic diseases. addresses paradox, where excessive supplementation can disrupt equilibrium, emphasizing importance balancing pro- antioxidative forces.

Язык: Английский

Процитировано

0
Personalized Dietary Impact Assessment Using Advanced Statistical Modeling DOI
Niraj Patel

Опубликована: Май 28, 2025

Precision nutrition relies on understanding how individuals uniquely respond to dietary interventions. This study utilizes a robust N-of-1 trial design involving 80 participants investigate postprandial glycemic responses two distinct diets. A hierarchical mixed-effects modeling framework was employed estimate individualized treatment effects and quantify interindividual variability. The model incorporated gut microbiome data explore interaction conditional (CATEs). Simulation-based power analysis confirmed the adequacy of sample size for detecting significant heterogeneity. Results demonstrated substantial variability in across individuals, with profiles accounting meaningful proportion this variance. proposed analytical supports development personalized strategies informed by biological markers, thus contributing advancement precision research.

Язык: Английский

Процитировано

0
Dietary Trials and Gut Candidate Phyla Radiation Bacteria: The Effect of Placebo on the Prevalence of Saccharibacteria in Healthy Armenian Women and Women with Familial Mediterranean Fever DOI
Natalya Harutyunyan, Lena Stepanyan, Lena Malkhasyan

и другие.

AgriScience and Technology, Год журнала: 2024, Номер unknown, С. 345 - 353

Опубликована: Янв. 1, 2024

“Candidate Phyla Radiation” (CPR) bacteria, representing ~15 % of bacterial diversity and over 70 phyla, are extremely small bacteria that primarily survive in parasitic or symbiotic forms. CPR including Candidatus Brownbacteria, Hugbacteria, Saccharibacteria (formerly TM7), were first identified humans 2007. They linked to the microbiota healthy diseased individuals, being present oral cavity, gastrointestinal, reproductive tracts. such as Saccharibacteria, associated with dysbiotic conditions like periodontitis can act pathogens potential protectors against inflammatory damage caused by host-associated bacteria.This study aimed assess effect a placebo on gut Armenian women those Familial Mediterranean Fever (FMF) disease, condition high prevalence Armenia often disturbances. Stool samples analyzed using culture-independent, high-density DNA microarray method, statistical analyses performed Multibase 2015 Excel Add-in program (NumericalDynamics, Tokyo, Japan). Results indicate respond variably depending health status, some showing significant quantitative qualitative changes while others remained unchanged. In conclusion, this confirms presence both FMF. The distinct responses intestinal highlight importance placebo-controlled trials research. Furthermore, findings emphasize role gut-brain processes their implications disease.

Язык: Английский

Процитировано

0