Augmenting Cognitive Function in the Elderly with Mild Cognitive Impairment Using Probiotic Lacticaseibacillus rhamnosus CBT-LR5: A 12-Week Randomized, Double-Blind, Parallel-Group Non-Comparative Study
Nutrients,
Год журнала:
2025,
Номер
17(4), С. 691 - 691
Опубликована: Фев. 14, 2025
Probiotics
have
been
shown
to
enhance
cognitive
function
in
individuals
with
mild
impairment
(MCI),
but
their
efficacy
varies,
depending
on
the
strain
and
dosage.
Clinical
investigations
are
crucial
confirm
safety,
efficacy,
mechanism
of
action.
This
study
was
designed
assess
effective
dosage,
MH-Pro,
a
test
product
containing
Lacticaseibacillus
rhamnosus
CBT-LR5
(LR5)
skim
milk
(non-fat
dry
milk),
improving
related
physiological
changes
older
adults
suspected
MCI
over
12
weeks.
In
total,
20
participants
(mean
age:
68.9
years)
were
randomly
assigned
1:1
ratio
either
low-dose
group
(1
×
1010
CFU
LR5
1622
mg)
or
high-dose
4055
mg
milk)
double-blind,
parallel-group
clinical
trial.
After
weeks,
showed
significant
improvements
MOCA-K
subdomains,
specifically
naming
(p
=
0.01)
delayed
recall
0.003).
Additionally,
levels
amyloid-β1
40/42
blood
significantly
decreased
0.03)
following
supplementation
group.
The
exhibited
improvement
orientation
0.05).
Moreover,
overall
enhancement
observed
0.003),
while
trend
toward
0.06).
Fecal
analysis
revealed
bacterial
composition,
an
increase
after
weeks
MH-Pro
consumption.
Together,
these
findings
provide
foundational
evidence
suggesting
that
may
serve
as
potential
intervention
for
enhancing
through
gut-brain
axis
pathways
elderly
population.
However,
given
small
sample
size
predominance
female
participants,
impact
outcome
be
limited.
Further
large-scale
studies
necessary
validate
preliminary
results.
provides
recognize
use
prepare
probiotic
supplement
enhances
aging
Язык: Английский
The Impact of the Exposome on Alzheimer’s Disease: The Influence of Nutrition
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 3015 - 3015
Опубликована: Март 26, 2025
Alzheimer's
disease
(AD)
is
a
progressive
neurodegenerative
characterized
by
cognitive
decline,
memory
loss,
and
behavioural
changes.
While
genetic
predispositions
pathological
processes
have
been
the
traditional
focus,
this
review
highlights
fundamental
role
of
environmental
factors,
particularly
nutrition,
within
exposome
framework
in
modulating
risk
progression
AD.
The
exposome,
which
includes
totality
exposures
an
individual's
lifetime,
provides
comprehensive
approach
to
understanding
complex
aetiology
In
review,
we
explore
impact
dietary
factors
cyclic
nucleotide
pathways
(cAMP/cGMP)
on
AD,
emphasizing
potential
interventions
as
therapeutic
strategies.
We
investigate
key
aspects
how
nutrition
affects
accumulation
β-amyloid,
aggregation
tau
proteins,
neuroinflammation.
also
examine
specific
nutrients
performance
Additionally,
discuss
nutraceuticals
with
anti-phosphodiesterase
activity
various
animal
models
AD
(such
5xFAD,
3xTg-AD,
Tg2576,
APP/PS1
mice)
demonstrating
effects
onset
progression.
Язык: Английский