Proteomic Diversity of the Sea Anemone Actinia fragacea: Comparative Analysis of Nematocyst Venom, Mucus, and Tissue-Specific Profiles
Marine Drugs,
Год журнала:
2025,
Номер
23(2), С. 79 - 79
Опубликована: Фев. 11, 2025
Sea
anemones
(Actiniaria,
Cnidaria)
are
promising
targets
for
biomedical
research,
as
they
produce
unique
bioactive
compounds,
including
toxins
and
antimicrobial
peptides
(AMPs).
However,
the
diversity
mechanisms
underlying
their
chemical
defenses
remain
poorly
understood.
In
this
study,
we
investigate
proteomic
profiles
of
unexplored
sea
anemone
Actinia
fragacea
by
analyzing
its
venom
nematocyst
extract,
tissues,
mucus
secretion.
A
total
4011
different
proteins
were
identified,
clustered
into
3383
protein
groups.
Among
83
putative
detected,
actinoporins,
neurotoxins,
phospholipase
A2
uncovered,
well
two
novel
zinc
metalloproteinases
with
specific
domains
(ShK)
associated
potassium
channel
inhibition.
Common
Gene
Ontology
(GO)
terms
related
to
immune
responses,
cell
adhesion,
protease
inhibition,
tissue
regeneration.
Furthermore,
1406
13,276
distinct
identified
predicted
potential
AMPs,
a
Aurelin-like
AMP
localized
within
nematocysts.
This
discovery
highlights
strengthens
evidence
cnidarian-exclusive
Aurelin
peptide
family.
Several
other
compounds
distinctive
defense
functions
also
enzymes,
pattern
recognition
(PRPs),
neuropeptides.
study
provides
first
proteome
map
A.
fragacea,
offering
critical
foundation
exploring
valuable
insights
molecular
complexity.
Язык: Английский
The role of ALF4 in the immune response of Scylla paramamosain against Vibrio alginolyticus and white spot syndrome virus (WSSV)
Fish & Shellfish Immunology,
Год журнала:
2025,
Номер
unknown, С. 110384 - 110384
Опубликована: Май 1, 2025
Язык: Английский
Microecological Preparations as Antibiotic Alternatives in Cyprinid Aquaculture
Fishes,
Год журнала:
2025,
Номер
10(6), С. 263 - 263
Опубликована: Июнь 2, 2025
Microecological
preparations
(MPs),
encompassing
probiotics,
prebiotics,
synbiotics,
and
postbiotics,
are
microbial
feed
supplements
that
enhance
host
health
through
gut
microbiota
modulation.
Unlike
the
narrow
definition
of
probiotics
(viable
microorganisms),
MPs
constitute
a
broader
category
including
non-viable
derivatives
selectively
fermented
substrates.
Their
application
in
aquaculture
significantly
reduces
antibiotic
dependence.
Given
industry’s
intensification
challenges,
while
meeting
global
protein
demands,
high-density
elevates
disease
risks,
driving
prophylactic
overuse.
This
practice
accelerates
antimicrobial
resistance
(AMR)
development,
compromising
treatment
efficacy
causing
residual
antibiotics
aquatic
products.
Such
residues
violate
international
food
safety
standards,
triggering
trade
disputes.
As
sustainable
alternatives,
operate
multiple
mechanisms:
competitive
exclusion
pathogens,
immune
stimulation,
nutrient
absorption
enhancement.
review
examines
patterns
abuse
emergence
AMR
carp
aquaculture,
evaluates
MP-based
mitigation
strategies
from
perspective
analyzes
advantages,
disadvantages,
progress
MPs.
Based
on
existing
evidence,
we
propose
targeted
research
priorities
for
MP
optimization,
advocating
scientifically
guided
implementation
commercial
cyprinid
aquaculture.
Язык: Английский