Discover Food, Год журнала: 2025, Номер 5(1)
Опубликована: Апрель 1, 2025
Язык: Английский
Frontiers in Pharmacology, Год журнала: 2025, Номер 15
Опубликована: Янв. 3, 2025
Anoectochilus roxburghii (Wall.) Lindl. (AR) is a perennial herb that has long been used as medicinal and edible plant. In Traditional Chinese Medicine (TCM), AR utilized to treat various diseases including hyperuricemia, type 2 diabetes mellitus, cancers inflammatory diseases. Recent advances in the discovery isolation of bio-active compounds have unveils main ingredients, such quercetin, kinsenoside rhamnazin. Pharmacological studies further demonstrated its activities, containing anti-inflammation, anti-oxidation, antihyperlipidemia effects. The processed products commercial applications functional foods cosmetics. prepare soup, drinkbeverage, jelly, face masks, soap, etc. However, despite abundant value, it hasn't included 2020 Pharmacopoeia up now. There also no consistent evaluation standard across provinces. This seriously affects safety efficacy TCM prescriptions, not mention development question. review summarizes recent research on phytochemistry, pharmacology, quality control applications, raises corresponding solutions provide references potential directions for studies.
Язык: Английский
Процитировано
0
Phytotherapy Research, Год журнала: 2025, Номер unknown
Опубликована: Янв. 4, 2025
ABSTRACT Saponins are compounds composed of lipophilic aglycones linked to hydrophilic sugars. Natural saponins isolated from plants and some Marine organisms. As important cholesterol‐lowering drugs, natural have attracted wide attention for their therapeutic potential in a variety cholesterol‐related metabolic diseases. To review the effects on diseases, deepen understanding mechanism saponins. The literature related diseases was collected using keywords “saponins” “cholesterol” PubMed, Web Science, Google Scholar January 2000 May 2024. total number articles 240 after excluding irrelevant articles. can regulate cholesterol prevent treat such as atherosclerosis, diabetes, liver disease, hyperlipidemia, cancer, obesity. Mechanistically, synthesis uptake through AMPK/SREBP2/3‐hydroxy‐3‐methyl‐glutaryl coenzyme A reductase pathway PCSK9/LDLR pathway, efflux esterification targeting Liver X receptor/ABC ACAT family. broad application prospects regulating metabolism, development more drugs provides new train thought. However, it is still necessary further explore molecular expand clinical trials provide evidence.
Язык: Английский
Процитировано
0
Journal of Ginseng Research, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Natural Product Communications, Год журнала: 2025, Номер 20(3)
Опубликована: Март 1, 2025
Diabetes mellitus is a long-term metabolic condition marked by chronically high levels of glucose in the blood due to insufficient synthesis insulin or impaired function. Throughout history, several civilizations have used traditional medicinal plants treat and control diabetes. This paper offers thorough review, date, antidiabetic natural compounds origin, specifically highlighting their reported modes mechanisms action therapeutic possibilities, with view fast-tracking possibility transition pharmaceutical products for human use. Phytochemicals such as flavonoids, alkaloids, terpenoids, glycosides notable effects. They been shown via many processes, including boosting secretion, improving sensitivity, blocking absorption \gastrointestinal-tract, regulating carbohydrate metabolism. Unlike earlier reviews, this current one, addition chemistry proposed action, also x-rays effectiveness safety these chemicals combining evidences from laboratory research, animal experiments, clinical trials. Several substances, Demethoxycurcumin, Trigonelline, Ginsenosides, progressed trials, while others like Allicin Polypeptide-p at bedside. Bisdemethoxycurcumin, Vicine, Gymnemosides, are now preclinical trial phase, suggesting that research still ongoing there promise future application. The review highlights evolution diabetes management, potential improve treatment. It suggests incorporating plant-derived into treatments, reducing dependence on drugs adverse
Язык: Английский
Процитировано
0
Discover Food, Год журнала: 2025, Номер 5(1)
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0