South African Journal of Botany, Год журнала: 2023, Номер 160, С. 273 - 281
Опубликована: Июль 13, 2023
Язык: Английский
Plants, Год журнала: 2021, Номер 10(12), С. 2762 - 2762
Опубликована: Дек. 14, 2021
The large-scale production of plant-derived secondary metabolites (PDSM) in bioreactors to meet the increasing demand for bioactive compounds treatment and prevention degenerative diseases is nowadays considered an engineering challenge due large number operational factors that need be during their design scale-up. plant cell suspension culture (CSC) has presented numerous benefits over other technologies, such as conventional whole-plant extraction, not only avoiding overexploitation species, but also achieving better yields having excellent scaling-up attributes. selection bioreactor configuration depends on intrinsic properties considerations related effect operating conditions thermodynamics, kinetics, transport phenomena, which together are essential accomplishing PDSM. To this end, review, firstly, provides a comprehensive appraisement PDSM, essentially those with demonstrated importance utilization pharmaceutical industries. Then, special attention given PDSM obtained out CSC. Finally, aspects CSC stating kinetics phenomena and, hence, viability accordingly. analysis reviewed configurations will pave way future research focused scaling up, produce high value-added
Язык: Английский
Процитировано
64
Evidence-based Complementary and Alternative Medicine, Год журнала: 2022, Номер 2022, С. 1 - 20
Опубликована: Март 27, 2022
The incidence of obesity and over bodyweight is emerging as a major health concern. Obesity complex metabolic disease with multiple pathophysiological clinical conditions comorbidities are associated such diabetes, hypertension, cardiovascular disorders, sleep apnea, osteoarthritis, some cancers, inflammation-based conditions. In obese individuals, adipocyte cells increased the expression leptin, angiotensin, adipocytokines, plasminogen activators, C-reactive protein. Currently, options for treatment lifestyle behaviors interventions limited, keeping healthy challenging. Various types phytochemicals have been investigated antiobesity potential. Here, we discuss pathophysiology signaling pathways in obesity, epigenetic regulations, regulatory mechanism, functional ingredients natural products, therapeutic application obesity.
Язык: Английский
Процитировано
43
Heliyon, Год журнала: 2023, Номер 9(11), С. e21196 - e21196
Опубликована: Окт. 24, 2023
Designing and manufacturing functional bioactive ingredients pharmaceuticals have grown worldwide. Consumers demand for safe concerns over harmful synthetic additives prompted food manufacturers to seek safer sustainable alternative solutions. In recent years the preference by consumers natural agents compounds increased exponentially, consequently, naturally derived phytochemicals compounds, with antimicrobial antioxidant properties, becoming essential in packaging field. response societal needs, needs be developed based on practices, marketing strategies, consumer behaviour, environmental concerns, emergence of new technologies, particularly bio- nanotechnology. This critical systematic review assessed role from resources behaviour patterns relation phytochemical biologically active substances used development packaging. The use inside materials industry could generate unpleasant odours diffusion most volatile material environment. These must addressed understand minimum concentrations that will not affect sensory aroma negative perceptions. research articles were carefully chosen selected following Preferred Reporting Items Systematic Reviews (PRISMA) guidelines.
Язык: Английский
Процитировано
33
Diabetes Care, Год журнала: 2024, Номер 47(5), С. 803 - 809
Опубликована: Фев. 13, 2024
OBJECTIVE Plant-based dietary patterns emphasize plant foods and minimize animal-derived foods. We investigated the association between plant-based diabetes in a community-based U.S. sample of Black White adults. RESEARCH DESIGN AND METHODS included middle-aged adults from Atherosclerosis Risk Communities (ARIC) study without at baseline who completed food-frequency questionnaire (n = 11,965). scored diet adherence according to three indices: overall, healthy, unhealthy indices. Higher overall index (PDI) scores represent greater intakes all lower healthy (hPDI) food intake (uPDI) used Cox regression estimate hazard ratios (HRs) for incident (defined self-reported diagnosis, medication use, or elevated blood glucose) associated with each index. RESULTS Over median follow-up 22 years, we identified 4,208 cases among subjects. PDI were risk (quintile 5 vs. 1 HR 0.89 [95% CI 0.80, 0.98]; Ptrend 0.01). hPDI also inversely 0.85 0.77, 0.94]; < 0.001). uPDI not risk. CONCLUSIONS A pattern that minimizes emphasizes may reduce
Язык: Английский
Процитировано
12
Molecules, Год журнала: 2022, Номер 27(18), С. 5851 - 5851
Опубликована: Сен. 9, 2022
The main characteristic feature of diabetes mellitus is the disturbance carbohydrate, lipid, and protein metabolism, which results in insulin insufficiency can also lead to resistance. Both acute chronic diabetic cases are increasing at an exponential rate, flagged by World Health Organization (WHO) International Diabetes Federation (IDF). Treatment with synthetic drugs often fails provide desired limits its use symptomatic treatment only. This has resulted exploration alternative medicine, herbal gaining popularity these days. Owing their safety benefits, compliance, ability exhibit effects without disturbing internal homeostasis, research field ayurvedic treatments gained importance. Medicinal phytoconstituents include micronutrients, amino acids, proteins, mucilage, critical oils, triterpenoids, saponins, carotenoids, alkaloids, flavonoids, phenolic tannins, coumarins, play a dynamic function prevention mellitus. Alkaloids found medicinal plants represent intriguing potential for inception novel approaches therapies. Thus, this review article highlights detailed information on alkaloidal phytoconstituents, includes sources structures alkaloids along associated mechanism involved management From available literature data presented, it be concluded that compounds hold tremendous as monotherapies or combination current treatments, result development better efficacy profiles.
Язык: Английский
Процитировано
35
Journal of Agriculture and Food Research, Год журнала: 2023, Номер 14, С. 100877 - 100877
Опубликована: Ноя. 21, 2023
This review aims to explore the various antinutritional factors found in grains and oilseeds, their sources, different methods employed mitigate effects. Both traditional innovative processing techniques have been utilized reduce antinutrients. Traditional such as dehulling, soaking, boiling, pressure cooking, sprouting, fermentation proven effective reducing specific antinutrients like α-galactosides, phytic acid, enzyme inhibitors, lathyrogens, lectins, saponins, tannins. However, optimization of these is necessary maximize effectiveness minimize antinutrient content. The also provides an overview analytical used quantify oilseeds. These encompass classical gravimetric titrimetric analysis, potentiometric titrations, chromatographic electrophoretic separation techniques, well spectroscopic methods, fluorescence, biosensors. A systematic chronological approaches detection systems presented. Furthermore, identifies research gaps highlights potential areas for future exploration field By addressing gaps, we can further enhance our understanding develop more strategies antinutrients, thus promoting utilization oilseeds optimal health benefits.
Язык: Английский
Процитировано
21
Life, Год журнала: 2023, Номер 13(9), С. 1831 - 1831
Опубликована: Авг. 29, 2023
Diabetes poses a significant global health challenge, necessitating innovative therapeutic strategies. Natural products and their derivatives have emerged as promising candidates for diabetes management due to diverse compositions pharmacological effects. Algae, in particular, garnered attention potential source of bioactive compounds with anti-diabetic properties. This review offers comprehensive overview algae-derived natural management, highlighting recent developments future prospects. It underscores the pivotal role care delves into diversity algae, constituents, underlying mechanisms efficacy. Noteworthy algal substantial are briefly elucidated, along specific contributions addressing distinct aspects diabetes. The challenges limitations inherent utilizing algae interventions examined, accompanied by strategic recommendations optimizing effectiveness. By these considerations, this aims chart course research refining algae-based approaches. Leveraging multifaceted activities chemical components holds promise pursuit novel antidiabetic treatments. Through continued fine-tuning interventions, burden could be mitigated, ultimately leading enhanced patient outcomes.
Язык: Английский
Процитировано
18
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 175, С. 116630 - 116630
Опубликована: Апрель 26, 2024
Recent advances in diabetes treatment have primarily focused on insulin and hypoglycemic agents; however, there is growing interest exploring herbal synthetic alternatives. Numerous studies highlighted the preventive effectiveness of regular plant consumption managing chronic conditions, particularly diabetes. Hibiscus, a medicinal recognized various cultures, known for its diverse health benefits. This study investigated impact Hibiscus trionum glycemic control assessed influence glucose levels diabetes-induced rats. The concentrations antioxidant enzymes, superoxide dismutase (SOD) glutathione peroxidase (GSH-Px), were scrutinized across multiple body tissues (plasma, heart, muscle, liver, kidney). malondialdehyde (MDA) concentration, an indicator lipid peroxidation, was examined both plasma tissue samples. Serum total cholesterol (TC), triglyceride (TG), aspartate aminotransferase (AST), alanine (ALT) evaluated. Diabetic Group (D) exhibited significant decrease weight, increased fluid food consumption, elevated blood levels, enzyme activity. Moreover, diabetic group also showed MDA, TC, TG, AST, ALT, along with reduced compared to group. A substantial improvement all parameters impaired by observed following application (HTT) Diabetes+HTT antioxidative stress-reducing, peroxidation-improving, hepatoprotective potential mitigating oxidative stress noteworthy. These findings indicate that HTT supplementation has valuable beneficial effects protecting against harmful impacts
Язык: Английский
Процитировано
7
Journal of Holistic Integrative Pharmacy, Год журнала: 2025, Номер 6(1), С. 50 - 56
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
ChemistrySelect, Год журнала: 2025, Номер 10(13)
Опубликована: Март 28, 2025
Abstract A simple, expedient continuously scalable flow chemistry synthesis of a range 1,4‐dimethylcarbazoles from substituted indoles and 2,5‐hexanedione in the presence K‐10 (montmorillonite clay) is reported. Optimization conditions led to development an in‐house K‐10/sand Omnifit TM catalyst column that at 140 °C 0.4 mL.min −1 afforded >90% conversion selected indole desired 1,4‐carbazole. This equates ca 80 mg.h production rate. The reaction was tolerant electron donating but not withdrawing indoles.
Язык: Английский
Процитировано
0