Future Pharmacology,
Год журнала:
2023,
Номер
3(1), С. 14 - 37
Опубликована: Янв. 4, 2023
Obesity
is
associated
with
a
significantly
increased
risk
of
cardiovascular
and
metabolic
diseases
such
as
diabetes
mellitus.
Recently,
growing
body
evidence
shows
that
phytochemicals,
especially
many
flavonoids,
place
an
inhibitory
regulatory
effect
on
adipogenesis,
obesity
diabetes.
With
computer-aided
drug
discovery,
the
action
modes
more
bioactive
flavonoids
are
being
identified
confirmed
at
molecular
level.
Citrus
fruit
peels
particularly
rich
in
which
have
demonstrated
strong
therapeutic
potentials
regulating
lipid
metabolisms.
However,
they
usually
thrown
away
after
consuming
flesh,
sometimes
even
causing
environmental
problems.
Thus,
extraction
useful
from
citrus
waste
for
pharmaceutical
industry
could
be
profitable
environmentally
friendly
solution
future,
advocating
concepts
circular
economy
sustainable
society.
The
aim
this
review
to
summarize
current
antiobesity
antidiabetic
extracted
fruits.
Our
results
suggest
various
potential
sources
novel
drugs
nutraceuticals.
Combining
experimental
data
artificial
intelligence
methods
study
would
facilitate
discovery
against
obesity-related
diseases.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(3), С. 1890 - 1890
Опубликована: Фев. 4, 2024
The
pursuit
for
better
skin
health,
driven
by
collective
and
individual
perceptions,
has
led
to
the
demand
sustainable
skincare
products.
Environmental
factors
lifestyle
choices
can
accelerate
aging,
causing
issues
like
inflammation,
wrinkles,
elasticity
loss,
hyperpigmentation,
dryness.
industry
is
innovating
meet
consumers'
requests
cleaner
natural
options.
Simultaneously,
environmental
concerning
waste
generation
have
been
leading
strategies
based
on
circular
economy.
A
noteworthy
solution
consists
of
citrus
by-product
valorization,
as
such
by-products
be
used
a
source
bioactive
molecules.
Citrus
processing,
particularly,
generates
substantial
amounts
(around
50%
whole
fruit),
unprecedented
burdens.
Hesperidin,
flavonoid
abundant
in
orange
peels,
considered
hold
immense
potential
clean
health
product
applications
due
its
antioxidant,
anti-inflammatory,
anticarcinogenic
properties.
This
review
explores
hesperidin
extraction
purification
methodologies
well
key
application
areas:
(i)
antiaging
barrier
enhancement,
(ii)
UV
radiation-induced
damage,
(iii)
hyperpigmentation
depigmentation
conditions,
(iv)
wound
healing,
(v)
cancer
other
cutaneous
diseases.
work's
novelty
lies
comprehensive
coverage
hesperidin's
promising
while
also
demonstrating
ingredient
from
economy
approach.
Frontiers in Plant Science,
Год журнала:
2024,
Номер
15
Опубликована: Март 25, 2024
Citrus
fruits,
revered
for
their
nutritional
value,
face
significant
threats
from
diseases
like
citrus
canker,
particularly
impacting
global
cultivation,
notably
in
Pakistan.
This
study
delves
into
the
critical
role
of
NPR1
-like
genes,
true
receptors
salicylic
acid
(SA),
defense
mechanisms
against
Xanthomonas
axonopodis
pv.
citri
(Xcc).
By
conducting
a
comprehensive
genome-wide
analysis
and
phylogenetic
study,
evolutionary
dynamics
limon
genes
across
diverse
cultivars
are
elucidated.
Structural
predictions
unveil
conserved
domains,
such
as
BTB
domain
ankyrin
repeat
crucial
mechanism.
Motif
reveals
essential
patterns,
while
cis-regulatory
elements
indicate
involvement
transcription,
growth,
response
to
phytohormones,
stress.
The
predominantly
cytoplasmic
nuclear
localization
underscores
pivotal
conferring
resistance
various
species.
Analysis
Ks/Ka
ratio
indicates
purifying
selection
emphasizing
importance
different
Synteny
chromosomal
mapping
provide
insights
duplication
events
orthologous
links
among
Notably,
Xac
infection
stimulates
expression
revealing
responsiveness
pathogenic
challenges.
Interestingly,
qRT-PCR
profiling
post-Xac
cultivar-specific
alterations
within
susceptible
resistant
varieties.
Beyond
genetic
factors,
physiological
parameters
peroxidase,
total
soluble
protein,
secondary
metabolites
respond
SA-dependent
PR
influencing
plant
characteristics.
Examining
impact
(NPR1)
characteristics
on
disease
citrus,
this
marks
inaugural
investigation
correlation
between
NPR1-associated
traits
both
varieties
bacterial
canker.
Applied Food Research,
Год журнала:
2022,
Номер
2(1), С. 100083 - 100083
Опубликована: Март 30, 2022
Huge
quantities
of
citrus
wastes,
especially
peels
are
generated
globally
and
they
an
environmental
menace
in
many
parts
the
world.
However,
have
been
use
folklore
oriental
medicines
for
management
degenerative
conditions
this
prompted
researchers
to
investigate
medicinal
properties
peels.
Various
research
efforts
showed
that
rich
vitamins,
fibers
bioactive
compounds.
The
possess
antioxidant,
antimicrobial,
antidiabetic,
antihypertensive,
anti-inflammatory
anticancer
properties.
benefits
also
encouraged
addition
various
diets.
Currently,
become
a
part
diet
regions
being
incorporated
into
food
products.
Studies
shown
incorporating
as
powder
or
essential
oils
products
improved
quality
without
negatively
affecting
sensory
attributes
when
added
at
right
amount.
Food
companies
already
enriching
with
still
offer
great
promises
development
functional
health
economic
benefits.
Over
time,
can
be
said
made
odyssey
from
waste
bin
laboratory
bench
now
dining
table.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(11), С. 9228 - 9228
Опубликована: Май 25, 2023
Recent
studies
on
natural
antioxidant
compounds
have
highlighted
their
potentiality
against
various
pathological
conditions.
The
present
review
aims
to
selectively
evaluate
the
benefits
of
catechins
and
polymeric
structure
metabolic
syndrome,
a
common
disorder
characterized
by
cluster
three
main
risk
factors:
obesity,
hypertension,
hyperglycemia.
Patients
with
syndrome
suffer
chronic
low
inflammation
state
oxidative
stress
both
conditions
effectively
countered
flavanols
polymers.
mechanism
behind
activity
these
molecules
has
been
correlated
characteristic
features
basic
flavonoidic
skelethon,
as
well
efficient
doses
needed
perform
in
vitro
vivo
studies.
amount
evidence
provided
this
offers
starting
point
for
flavanol
dietary
supplementation
potential
strategy
counteract
several
targets
associated
suggests
key
role
albumin
flavanol-delivery
system
different
target
action
inside
organism.
Frontiers in Physiology,
Год журнала:
2023,
Номер
14
Опубликована: Июнь 30, 2023
Introduction:
Aging
is
a
process
characterised
by
decline
in
physiological
functions.
Reactive
species
play
crucial
role
the
aging
rate.
Due
to
close
relationship
between
and
oxidative
stress,
functional
foods
rich
phytochemicals
are
excellent
candidates
neutralise
age-related
changes.
Aim:
This
investigation
aims
verify
potential
protective
of
bergamot
(
Citrus
bergamia
,
Femminello
cultivar)
peel
juice
extract
model
represented
human
red
blood
cells
(RBCs)
exposed
D-Galactose
(DGal).
Methods:
Bergamot
extracts
were
subjected
RP-HPLC/PDA/MS
for
determination
their
composition
bioactive
compounds.
Markers
including
ROS
production,
thiobarbituric
acid
reactive
substances
(TBARS)
levels
-a
marker
lipid
peroxidation,
oxidation
total
protein
sulfhydryl
groups,
as
well
expression
anion
exchange
capability
band
3
glycated
haemoglobin
(A1c)
production
have
been
investigated
RBCs
treated
with
D-Gal
24
h,
or
without
pre-incubation
15
min
5
μg/mL
extract.
In
addition,
activity
endogenous
antioxidant
system,
catalase
(CAT)
superoxide
dismutase
(SOD),
diversion
RBC
metabolism
from
glycolysis
towards
pentose
phosphate
pathway
shunt,
denoted
activation
glucose-6-phosphate
dehydrogenase
(G6PDH),
explored.
Results:
Data
shown
here
suggest
that
i)
prevented
D-Gal-induced
consequently,
stress
injury
biological
macromolecules
membrane
lipids
proteins;
ii)
significantly
restored
alterations
distribution
ion
transport
kinetics
3;
iii)
blunted
A1c
production;
iv)
effectively
impeded
over-activation
enzymes
CAT
SOD;
v)
G6PDH.
Discussion:
These
results
further
contribute
shed
light
on
mechanisms
identify
food
natural
antioxidants
useful
prevention
treatment
stress-related
changes,
which
may
lead
pathological
states
during
aging.
Pharmaceuticals,
Год журнала:
2023,
Номер
16(8), С. 1081 - 1081
Опубликована: Июль 29, 2023
Citrus
fruits
processing
results
in
the
generation
of
huge
amounts
citrus
by-products,
mainly
peels,
pulp,
membranes,
and
seeds.
Although
they
represent
a
major
concern
from
both
economical
environmental
aspects,
it
is
very
important
to
emphasize
that
these
by-products
contain
rich
source
value-added
bioactive
compounds
with
wide
spectrum
applications
food,
cosmetic,
pharmaceutical
industries.
The
primary
aim
this
review
highlight
great
potential
isolated
phytochemicals
extracts
individual
properties
(e.g.,
antitumor,
antimicrobial,
antiviral,
antidiabetic,
antioxidant,
other
beneficial
activities
health-promoting
abilities)
their
pharmaceutical,
biomedical,
biological
applications.
This
on
contains
following
parts:
structural
chemical
characteristics;
utilization
by-products;
bioactivities
present
waxes
carotenoids,
essential
oils,
pectins,
phenolic
compounds;
by-product
formulations
enhanced
biocactivities.
A
summary
recent
developments
applying
for
treatment
different
diseases
protection
human
health
also
provided,
emphasizing
innovative
methods
bioaccessibility
enhancements
extract/component
encapsulation,
synthesis
biomass-derived
nanoparticles,
nanocarriers,
or
biofilm
preparation).
Based
representative
phytochemical
groups,
an
evaluation
studies
past
six
years
(from
2018
2023)
reporting
specific
citrus-based
provided.
Finally,
discusses
advanced
modern
approaches
pharmaceutical/biological
drug
delivery
carbon
precursors
preparation
nanoparticles
promising
antimicrobial
activity,
production
fluorescent
application
as
antitumor
agents,
cellular
imaging).
implementing
nanotechnology
food
science
biotechnology
could
bring
about
new
insights
into
providing
solutions
medical
discoveries.
Nutrients,
Год журнала:
2024,
Номер
16(2), С. 259 - 259
Опубликована: Янв. 15, 2024
Chronic
inflammation
is
the
result
of
an
acute
inflammatory
response
that
fails
to
eliminate
pathogenic
agent
or
heal
tissue
injury.
The
consequence
this
failure
lays
foundations
onset
several
chronic
ailments,
including
skin
disorders,
respiratory
and
neurodegenerative
diseases,
metabolic
syndrome,
and,
eventually,
cancer.
In
context,
long-term
use
synthetic
anti-inflammatory
drugs
treat
illnesses
cannot
be
tolerated
by
patients
owing
severe
side
effects.
Based
on
this,
need
for
novel
agents
endowed
with
effects
prompted
search
potential
candidates
also
within
plant
kingdom,
being
recognized
as
a
source
molecules
currently
employed
in
therapeutical
areas.
Indeed,
ever-growing
evidence
properties
dietary
polyphenols
traced
route
towards
study
flavonoid-rich
sources,
such
Citrus
bergamia
(bergamot)
its
derivatives.
Interestingly,
recent
paradigm
circular
economy
has
promoted
valorization
fruit
waste
regard
bergamot,
it
brought
light
new
corroborating
bergamot
byproducts,
thus
increasing
scientific
knowledge
field.
Therefore,
review
aims
gather
latest
literature
supporting
beneficial
role
both
derivatives
products
different
models
inflammatory-based
highlighting
great
potentiality
re-evaluation
perspective.
