Meditsinskiy sovet = Medical Council,
Год журнала:
2023,
Номер
17(9), С. 40 - 46
Опубликована: Июнь 24, 2023
In
the
prescriptions
of
an
endocrinologist
to
patients
with
diabetes
mellitus,
glucagon-like
peptide
agonists,
belonging
group
that
affects
incretin
system
body,
have
recently
been
increasingly
appearing.
addition
pronounced
hypoglycemic
effect
and
high
safety,
these
drugs
also
many
pleiotropic
properties
due
presence
receptors
in
vascular
endothelium,
kidneys,
heart
nervous
tissue.
The
purpose
this
work
is
describe
most
studied
neuroprotective
effects
class
drugs.
As
materials
course
work,
studies
domestic
foreign
colleagues
published
period
from
2008
2022
were
used.
Our
has
shown
GLP-1
associated
activation
corresponding
receptor
systems
central
system,
which
leads
increased
cellular
survival
ischemic
conditions
by
reducing
reactive
oxygen
species,
stimulating
beta-oxidation
mitochondria,
pro-inflammatory
cytokines.
addition,
analysis
literature
established
positive
role
neurodegenerative
diseases
–
reduce
amount
unnormal
proteins
(alphasynuclein,
microtubular
T-peptide,
etc.),
activity
non-enzymatic
glycation
hyperglycemia,
as
well
insulin
resistance.
described
above
analyzed
during
preclinical
trials
GLP-1,
demonstrated
their
validity
human
models
some
clinical
trials.
However,
data
obtained
not
yet
sufficient
form
clear
indications
for
neurology,
so
topic
requires
further
study
large
Food Science & Nutrition,
Год журнала:
2024,
Номер
12(11), С. 9414 - 9427
Опубликована: Окт. 10, 2024
Abstract
The
rising
incidence
rate
of
depression
presents
a
substantial
threat
to
human
well‐being.
Semen
Trigonellae
(ST),
the
dried
mature
seeds
Trigonella
foenum‐graecum
L.,
has
long‐standing
traditional
reputation
for
alleviating
anxiety
and
hopelessness.
However,
anti‐depressant
mechanism
ST
remains
poorly
understood.
This
study
aimed
assess
ST's
anti‐depressant,
as
well
explore
its
potential
from
gut
microbial
aspect.
Kunming
mice
were
challenged
by
lipopolysaccharide
(LPS)
induce
depression‐like
behavior
then
orally
administrated
with
aqueous
extract
ST.
behavioral
test,
hippocampal
serum
biochemical
indicators
detected
effect
We
utilized
full‐length
16S
rRNA
gene
sequencing
investigate
how
influences
microbiota
modulation.
Administration
mitigated
LPS‐induced
behaviors.
reversed
decrease
in
5‐hydroxytryptamine
(5‐HT)
brain‐derived
neurotrophic
factor
(BDNF)
levels
while
reducing
tumor
necrosis
α
(TNF‐α),
interleukin
1β
(IL‐1β),
6
(IL‐6).
Microbial
analysis
revealed
that
administration
markedly
shifted
structure,
dramatically
dose‐dependently
increased
abundance
Ligilactobacillus
murinus
animalis
.
Experimentally,
oral
live
L
LPS‐challenged
yielded
similar
effects
ameliorating
depression,
elevating
5‐HT
BDNF,
proinflammatory
cytokines.
These
findings
provide
evidence
is
promising
medical
food
management
which
modulation
microbiota,
particularly
enhancing
plays
an
important
role.
Buildings,
Год журнала:
2022,
Номер
12(8), С. 1133 - 1133
Опубликована: Июль 31, 2022
The
health
of
humans
and
the
planet
are
most
vital
contemporary
issues
essential
components
Sustainable
Development
Goals
(SDGs).
Scientists
professionals
strive
for
integrated,
evolving,
healthy,
sustainable
solutions
encompassing
biodiversity
industrial
ecology,
while
offering
viable
economic
attainments.
building
industry,
especially
construction,
is
an
extensive
counterpart
that
largely
influences
on
various
levels.
On
a
practical
scale,
direct
or
indirect
impacts
related
to
conventional
construction
systems
(CCSs),
particularly
their
materialisations
implementation
methods.
Therefore,
from
global
perspective,
emerging
technologies
remodelled
methods
accomplish
use,
reuse,
recycling,
improving
planet’s
ensure
wellbeing
its
inhabitants,
crucial.
current
research
part
broader
study
“programmable
systems”
(PCSs),
concentrating
materials”
(PCMs)
health.
reviewed,
relevancies
addressed,
health-oriented
concepts
discussed.
Example
formulation
simplified
toolkit
creations
follow
problems’
sources
in
case
study,
providing
insight
into
resulting
multiscale
real-life
practices.
results
prove
method’s
potential
validate
simplicity
applicability
through
abstract
examination
newly
built
study.
Finally,
summarised
outcomes
other
studies
societal
preferences
also
confirm
feasibility
hypothesis
(i.e.,
healthy
materialisation)
social
perspective.
Meditsinskiy sovet = Medical Council,
Год журнала:
2023,
Номер
17(9), С. 40 - 46
Опубликована: Июнь 24, 2023
In
the
prescriptions
of
an
endocrinologist
to
patients
with
diabetes
mellitus,
glucagon-like
peptide
agonists,
belonging
group
that
affects
incretin
system
body,
have
recently
been
increasingly
appearing.
addition
pronounced
hypoglycemic
effect
and
high
safety,
these
drugs
also
many
pleiotropic
properties
due
presence
receptors
in
vascular
endothelium,
kidneys,
heart
nervous
tissue.
The
purpose
this
work
is
describe
most
studied
neuroprotective
effects
class
drugs.
As
materials
course
work,
studies
domestic
foreign
colleagues
published
period
from
2008
2022
were
used.
Our
has
shown
GLP-1
associated
activation
corresponding
receptor
systems
central
system,
which
leads
increased
cellular
survival
ischemic
conditions
by
reducing
reactive
oxygen
species,
stimulating
beta-oxidation
mitochondria,
pro-inflammatory
cytokines.
addition,
analysis
literature
established
positive
role
neurodegenerative
diseases
–
reduce
amount
unnormal
proteins
(alphasynuclein,
microtubular
T-peptide,
etc.),
activity
non-enzymatic
glycation
hyperglycemia,
as
well
insulin
resistance.
described
above
analyzed
during
preclinical
trials
GLP-1,
demonstrated
their
validity
human
models
some
clinical
trials.
However,
data
obtained
not
yet
sufficient
form
clear
indications
for
neurology,
so
topic
requires
further
study
large
