Exogenous Nucleotides Improve the Skin Aging of SAMP8 Mice by Modulating Autophagy through MAPKs and AMPK Pathways DOI Open Access
Rui Fan, Ying Zhang, Rui Liu

и другие.

Nutrients, Год журнала: 2024, Номер 16(12), С. 1907 - 1907

Опубликована: Июнь 17, 2024

The skin, serving as the body’s primary defense against external elements, plays a crucial role in protecting body from infections and injuries, well maintaining overall homeostasis. Skin aging, common manifestation of aging process, involves gradual deterioration its normal structure repair mechanisms. Addressing issue skin is increasingly imperative. Multiple pieces evidence indicate potential anti-aging effects exogenous nucleotides (NTs) through their ability to inhibit oxidative stress inflammation. This study aims investigate whether NTs can slow down elucidate underlying To achieve this objective, senescence-accelerated mouse prone-8 (SAMP8) mice were utilized randomly allocated into Aging, NTs-low, NTs-middle, NTs-high groups, while resistant 1 (SAMR1) employed control group. After 9 months NT intervention, dorsal samples collected analyze pathology assess presence expression substances related process. findings indicated that high-dose treatment led significant increase thickness epithelium dermal layers, Hyp content (p < 0.05). Additionally, it was observed low-dose intervention resulted improved evidenced by decrease p16 Importantly, administration high doses could improve, some ways, mitochondrial function, which known reduce promote ATP NAD+ production significantly. These may be linked NT-induced autophagy, decreased p62 increased LC3BI/II groups. Furthermore, found upregulate pAMPK PGC-1α inhibiting phosphorylation p38MAPK, JNK, ERK, suggesting autophagy regulated AMPK MAPK pathways. Therefore, induction offer benefits addressing activation pathway inhibition pathway.

Язык: Английский

The role of mitochondrial quality surveillance in skin aging: Focus on mitochondrial dynamics, biogenesis and mitophagy DOI
Chang Zhang, Xingyu Gao,

Minghe Li

и другие.

Ageing Research Reviews, Год журнала: 2023, Номер 87, С. 101917 - 101917

Опубликована: Март 25, 2023

Язык: Английский

Процитировано

39
Investigating the antioxidant and anti-inflammatory potential of Nypa fruticans: a multifaceted approach to skin protection and aging DOI Creative Commons
Seul Ki Kim, Sang-Back Kim, Seul Bi Lee

и другие.

Applied Biological Chemistry, Год журнала: 2025, Номер 68(1)

Опубликована: Янв. 16, 2025

Abstract Reactive oxygen species (ROS) produced in the mitochondria of skin cells play a significant role degradation extracellular matrix and induction inflammatory responses, both which are major contributors to aging. Antioxidants that reduce ROS production inhibit lesions considered beneficial for treatment diseases prevention In this study, we evaluated potential Nypa fruticans (NF), is known its antioxidant properties, mitigate tumor necrosis factor-alpha (TNF-α)- interferon-gamma (IFN-γ)-induced damage normal human epidermal keratinocytes. The active constituents identified NF include protocatechuic acid, hydroxybenzoic procyanidin B, catechin, epicatechin. significantly suppressed ROS, nitric oxide (NO), prostaglandin E2 (PGE 2 ), while also reducing levels cytokines interleukin-6 (IL-6) interleukin-1 beta (IL-1β), were elevated by TNF-α/IFN-γ stimulation. Furthermore, restored expression key barrier-related proteins such as serine peptidase inhibitor kazal type 5 (SPINK5), collagen I alpha 1 chain (COLIA1), loricrin (LOR), aquaporin-3 (AQP3), filaggrin (FLG). Additionally, upregulated hyaluronan synthase (HAS) -1 − β-defensin (HBD) -2 3, important hydration innate immune defense. These findings underscore therapeutic applications (NF) mitigating oxidative stress, inflammation, barrier dysfunction, dehydration, microbial imbalances. By targeting multiple pathways implicated aging, represents promising comprehensive approach preserving health addressing age-related dermatological conditions. Moreover, holds not only alleviate manifestations aging but provide basis development innovative therapies. Future investigations should aim further elucidate clinical dermatology maximize benefits.

Язык: Английский

Процитировано

1
The mitochondriotropic antioxidants AntiOxBEN2 and AntiOxCIN4 are structurally-similar but differentially alter energy homeostasis in human skin fibroblasts DOI
José Teixeira, Sofia Benfeito,

Rodrigo Carreira

и другие.

Biochimica et Biophysica Acta (BBA) - Bioenergetics, Год журнала: 2025, Номер 1866(2), С. 149535 - 149535

Опубликована: Янв. 7, 2025

Язык: Английский

Процитировано

0
Kombucha as a Potential Active Ingredient in Cosmetics—An Ex Vivo Skin Permeation Study DOI Creative Commons
Karolina Jakubczyk, Anna Nowak, Anna Muzykiewicz-Szymańska

и другие.

Molecules, Год журнала: 2024, Номер 29(5), С. 1018 - 1018

Опубликована: Фев. 26, 2024

Kombucha is a non-alcoholic beverage, that increasingly used in the cosmetic industry. The available literature reports positive effects of kombucha on skin, particular its antioxidant action. However, there lack information skin permeation and accumulation active ingredients showing such effects. Skin aging largely dependent oxidative stress, therefore our study we assessed ex vivo two types (green black tea) through porcine skin. activity (DPPH, ABTS, FRAP methods) total polyphenol content these extracts were determined before after testing. Moreover, selected phenolic acids as well caffeine was assessed. using Franz diffusion cell. both Kombuchas found to be high. In addition, gallic acid, chlorogenic protocatechuic coumaric m-hydroxybenzoic identified. A 24-h showed some their Our results confirm importance studying what are still little known preparations. Evaluation can guarantee efficacy

Язык: Английский

Процитировано

3
Metabolic Priming as a Tool in Redox and Mitochondrial Theragnostics DOI Creative Commons
Sónia Pinho, Sandra I. Anjo, Teresa Cunha‐Oliveira

и другие.

Antioxidants, Год журнала: 2023, Номер 12(5), С. 1072 - 1072

Опубликована: Май 10, 2023

Theragnostics is a promising approach that integrates diagnostics and therapeutics into single personalized strategy. To conduct effective theragnostic studies, it essential to create an in vitro environment accurately reflects the vivo conditions. In this review, we discuss importance of redox homeostasis mitochondrial function context approaches. Cells have several ways respond metabolic stress, including changes protein localization, density, degradation, which can promote cell survival. However, disruption lead oxidative stress cellular damage, are implicated various diseases. Models dysfunction should be developed metabolically conditioned cells explore underlying mechanisms diseases develop new therapies. By choosing appropriate model, adjusting culture conditions validating possible identify most therapeutic options tailor treatments individual patients. Overall, highlight precise individualized approaches theragnostics need accurate models reflect

Язык: Английский

Процитировано

5
Exogenous Nucleotides Improve the Skin Aging of SAMP8 Mice by Modulating Autophagy through MAPKs and AMPK Pathways DOI Open Access
Rui Fan, Ying Zhang, Rui Liu

и другие.

Nutrients, Год журнала: 2024, Номер 16(12), С. 1907 - 1907

Опубликована: Июнь 17, 2024

The skin, serving as the body’s primary defense against external elements, plays a crucial role in protecting body from infections and injuries, well maintaining overall homeostasis. Skin aging, common manifestation of aging process, involves gradual deterioration its normal structure repair mechanisms. Addressing issue skin is increasingly imperative. Multiple pieces evidence indicate potential anti-aging effects exogenous nucleotides (NTs) through their ability to inhibit oxidative stress inflammation. This study aims investigate whether NTs can slow down elucidate underlying To achieve this objective, senescence-accelerated mouse prone-8 (SAMP8) mice were utilized randomly allocated into Aging, NTs-low, NTs-middle, NTs-high groups, while resistant 1 (SAMR1) employed control group. After 9 months NT intervention, dorsal samples collected analyze pathology assess presence expression substances related process. findings indicated that high-dose treatment led significant increase thickness epithelium dermal layers, Hyp content (p < 0.05). Additionally, it was observed low-dose intervention resulted improved evidenced by decrease p16 Importantly, administration high doses could improve, some ways, mitochondrial function, which known reduce promote ATP NAD+ production significantly. These may be linked NT-induced autophagy, decreased p62 increased LC3BI/II groups. Furthermore, found upregulate pAMPK PGC-1α inhibiting phosphorylation p38MAPK, JNK, ERK, suggesting autophagy regulated AMPK MAPK pathways. Therefore, induction offer benefits addressing activation pathway inhibition pathway.

Язык: Английский

Процитировано

1