ABSTRACT
Natural
polymers
have
recently
been
investigated
for
various
applications,
such
as
3D
printing
and
healthcare,
including
treating
infections.
Among
microbial
infections,
fungal
diseases
remain
overlooked,
with
limited
therapeutic
options
high
recurrence.
Cutaneous
cryptococcosis
is
an
opportunistic
infection
triggered
by
mechanical
inoculation
or
hematogenous
dissemination
of
the
yeast
that
causes
cryptococcal
pneumonia
meningitis.
Every
year,
Cryptococcus
neoformans
endanger
lives
immunosuppressed
hosts,
resulting
in
180,000
deaths
per
year.
Nonetheless,
healthy
individuals
can
also
be
affected
this
infection.
Cryptococcosis
has
a
restricted
expensive
regimen
no
topical
approach
to
skin
manifestations.
This
study
sought
create
printable
biodegradable
polymeric
hydrogel
carrying
ketoconazole,
low‐cost
antifungal
drug
reported
anticryptococcal
activity.
The
developed
exhibited
good
printability
rheological
properties,
pseudoplastic
behavior.
FTIR
spectra
cross‐linked
hydrogels
revealed
interactions
between
alginate
Ca
+2
,
referred
egg‐box
model,
indicated
decrease
peaks
at
1600
1410
cm
−1
.
Furthermore,
loaded
ketoconazole
showed
remarkable
activity
against
C.
strains
inhibition
zones,
which
cross‐linking
did
not
seem
affect
its
performance.
material
remained
structurally
stable
up
12
days
(288
h)
swelling
studies,
preliminary
cytotoxicity
performed
V79
cells
indicates
potential
vivo
studies
application.
Gels,
Год журнала:
2024,
Номер
10(7), С. 472 - 472
Опубликована: Июль 17, 2024
The
study
aims
to
determine
how
chitosan
impacts
pectin
hydrogel’s
ability
attach
peritoneal
leukocytes,
activate
complement,
induce
hemolysis,
and
adsorb
blood
proteins.
hydrogels
PEC-Chi0,
PEC-Chi25,
PEC-Chi50,
PEC-Chi75
were
prepared
by
placing
a
mixture
solution
of
4%
in
ratio
4:0,
3:1,
2:2,
1:3
1.0
M
CaCl2.
Chitosan
was
found
modify
the
mechanical
properties
pectin–calcium
hydrogels,
such
as
hardness
cohesiveness-to-adhesiveness
ratio.
hydrogel
caused
pH-sensitive
swelling
Hanks’
solution.
shown
serum
proteins
at
pH
7.4
greater
extent
than
other
hydrogels.
PEC-Chi75’s
strong
adsorption
capacity
related
lower
leukocyte
adherence
its
surface
when
compared
showing
improved
biocompatibility.
Using
optical
tweezers
approach,
it
that
force
interaction
between
pectin–chitosan
plasma
increased
from
10
24
pN
with
increasing
content
0
75%.
Thus,
hydrogel,
which
interactions
body
tissues
after
implantation,
are
addition
chitosan,
making
promising
candidate
for
smart
biomaterial
development.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(15), С. 8406 - 8406
Опубликована: Авг. 1, 2024
Chitosan,
alginate,
and
chitosan–alginate
(50:50)
mixed
hydrogels
were
prepared
by
freeze
casting,
freeze-drying,
subsequent
physical
cross-linking.
Chitosan
was
cross-linked
with
citrate
alginate
calcium
ions,
while
the
gels
both
cross-linking
agents.
Both
cryogels
xerogels
obtained
lyophilization
drying
of
hydrogels.
We
investigated
effect
chemical
composition
state
on
gel
structure
sorption
model
dyes.
Alginate
Ca2+
ions
sorbed
80–95%
cationic
dye
from
solutions.
The
chitosan
are
primarily
capable
adsorbing
anionic
dyes,
but
at
near-neutral
pH,
their
capacity
is
lower
than
that
gels,
showing
50–60%
sorption.
In
case
xerogels,
cryogels,
same,
for
adsorbed
slightly
less
dried
gels.
European Journal of Dentistry,
Год журнала:
2024,
Номер
18(04), С. 1135 - 1141
Опубликована: Май 2, 2024
The
aim
of
this
research
was
to
analyze
expression
vascular
endothelial
growth
factor
(VEGF),
blood
vessels,
and
fibroblast
cell
proliferation
in
direct
pulp
capping
treatment
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(20), С. 11183 - 11183
Опубликована: Окт. 17, 2024
Implants
made
of
biodegradable
polymers
are
replaced
by
regenerating
tissues
through
inflammation.
The
changes
occurring
in
and
the
organism
practical
interest
for
studying
biocompatibility
material
searching
systemic
markers
blood
that
reflect
inflammation
peri-implantation
tissues.
highly
sensitive
C-reactive
protein
(hs-CRP)
measurements
morphometric
studies
tissue
surrounding
implant
were
carried
out
experiment
within
three
months
implantation
a
biopolymer
consisting
polycaprolactone
(PCL)
polytrimethylene
carbonate
(PTMC).
During
first
month,
decreased,
level
hs-CRP
did
not
increase.
polymer
biotransformation
began
after
month
was
accompanied
moving
deeper
into
matrix.
Proliferation
inflammatory
cells
reflected
an
increase
installation.
result
achieved
confirmed
polymer’s
bioinertness.
animals
correlated
with
tissues,
reflecting
activity
process
biotransformation.
This
can
be
recommended
assessing
processes
following
biopolymers
their
biocompatibility.
ABSTRACT
Natural
polymers
have
recently
been
investigated
for
various
applications,
such
as
3D
printing
and
healthcare,
including
treating
infections.
Among
microbial
infections,
fungal
diseases
remain
overlooked,
with
limited
therapeutic
options
high
recurrence.
Cutaneous
cryptococcosis
is
an
opportunistic
infection
triggered
by
mechanical
inoculation
or
hematogenous
dissemination
of
the
yeast
that
causes
cryptococcal
pneumonia
meningitis.
Every
year,
Cryptococcus
neoformans
endanger
lives
immunosuppressed
hosts,
resulting
in
180,000
deaths
per
year.
Nonetheless,
healthy
individuals
can
also
be
affected
this
infection.
Cryptococcosis
has
a
restricted
expensive
regimen
no
topical
approach
to
skin
manifestations.
This
study
sought
create
printable
biodegradable
polymeric
hydrogel
carrying
ketoconazole,
low‐cost
antifungal
drug
reported
anticryptococcal
activity.
The
developed
exhibited
good
printability
rheological
properties,
pseudoplastic
behavior.
FTIR
spectra
cross‐linked
hydrogels
revealed
interactions
between
alginate
Ca
+2
,
referred
egg‐box
model,
indicated
decrease
peaks
at
1600
1410
cm
−1
.
Furthermore,
loaded
ketoconazole
showed
remarkable
activity
against
C.
strains
inhibition
zones,
which
cross‐linking
did
not
seem
affect
its
performance.
material
remained
structurally
stable
up
12
days
(288
h)
swelling
studies,
preliminary
cytotoxicity
performed
V79
cells
indicates
potential
vivo
studies
application.
