Plant-derived epi-nutraceuticals as Potential Broad-Spectrum Anti-Viral Agents

Опубликована: Окт. 19, 2023

Although the COVID-19 pandemic appears to be diminishing, emergence of SARS-CoV-2 variants represents a threat humans due its inherent transmissibility, immunological evasion, virulence, and invulnerability existing therapies. The previous affected more than 500 million people caused over 6 deaths. Vaccines are essential, but in circumstances when vaccination is not accessible or individuals with compromised immune systems, drugs can give additional protection. Targeting host signaling pathways recommended their genomic stability resistance barriers. Plant-derived products, which have been used traditional medicine for treating pathological conditions, offer structurally novel therapeutic compounds including anti-viral. In addition, plant-derived bioactive substances might serve as ideal basis developing sustainable/efficient/cost-effective anti-viral alternatives. Epigenetic modifications genome affect gene expression without altering DNA sequence. Host cells use epigenetic regulation mechanism silence incoming viral molecules, while viruses recruited cellular epi transcriptomic (covalent RNAs) modifiers increase translational efficiency transcript transcripts enhance replication. Moreover, manipulate cells' machinery ensure productive infections. Environmental factors, such natural may influence modifications. this review, we exploring potential broad-spectrum activity, reviewing modulation processes effects on RNA viruses, addressing future research objectives rapidly emerging field.

Язык: Английский

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Antiviral Potential of Specially Selected Bulgarian Propolis Extracts: In Vitro Activity against Structurally Different Viruses

Life, Год журнала: 2023, Номер 13(7), С. 1611 - 1611

Опубликована: Июль 23, 2023

Propolis is a natural mixture of resins, wax, and pollen from plant buds flowers, enriched with enzymes bee saliva. It also contains various essential oils, vitamins, mineral salts, trace elements, hormones, ferments. has been found that propolis possesses antimicrobial, antiviral, anti-inflammatory properties. We have studied the antiviral activity six extracts Bulgarian collected districts Bulgaria. The study was conducted against structurally different viruses: human coronavirus strain OC-43 (HCoV OC-43) respiratory syncytial virus type 2 (HRSV-2) (enveloped RNA viruses), herpes simplex 1 (HSV-1) DNA virus), rhinovirus 14 (HRV-14) (non-enveloped virus) adenovirus 5 (HadV-5) virus). influence on internal replicative cycle viruses determined using cytopathic effect (CPE) inhibition test. virucidal activity, its impact stage viral adsorption to host cell, protective healthy cells were evaluated final dilution method, making them focal points interest. change in infectivity under action compared untreated controls, Δlgs determined. Most samples administered during demonstrated strongest HCoV replication. viability extracellular virions expressed degree studied, significantly stronger those an envelope. Almost all inhibited step and, less extent, some applied before infection cells. Our results enlarge knowledge about could open new perspectives for application treatment.

Язык: Английский

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Plant-Derived Epi-Nutraceuticals as Potential Broad-Spectrum Anti-Viral Agents

Nutrients, Год журнала: 2023, Номер 15(22), С. 4719 - 4719

Опубликована: Ноя. 8, 2023

Although the COVID-19 pandemic appears to be diminishing, emergence of SARS-CoV-2 variants represents a threat humans due their inherent transmissibility, immunological evasion, virulence, and invulnerability existing therapies. The affected more than 500 million people caused over 6 deaths. Vaccines are essential, but in circumstances which vaccination is not accessible or individuals with compromised immune systems, drugs can provide additional protection. Targeting host signaling pathways recommended genomic stability resistance barriers. Moreover, targeting factors allows us develop compounds that effective against different viral as well newly emerging virus strains. In recent years, globe has experienced climate change, may contribute spread infectious diseases through variety factors. Warmer temperatures changing precipitation patterns increase geographic range disease-carrying vectors, increasing risk spreading new areas. Climate change also affect vector behavior, leading longer breeding season sites for disease vectors. disrupt ecosystems, bringing closer wildlife transmits zoonotic diseases. All above accelerate epidemics. Plant-derived products, have been used traditional medicine treating pathological conditions, offer structurally novel therapeutic compounds, including those anti-viral activity. addition, plant-derived bioactive substances might serve ideal basis developing sustainable/efficient/cost-effective alternatives. Interest herbal antiviral products increased. More 50% approved originate from sources. diverse structures molecules candidates drug development. Combining these therapies conventional could improve patient outcomes. Epigenetics modifications genome gene expression without altering DNA sequences. Host cells use epigenetic regulation mechanism silence incoming molecules, while viruses recruit cellular epitranscriptomic (covalent RNAs) modifiers translational efficiency transcript transcripts enhance replication. manipulate cells' machinery ensure productive infections. Environmental factors, such natural influence modifications. this review, we explore potential broad-spectrum activity, reviewing modulation processes effects on RNA viruses, addressing future research objectives rapidly field.

Язык: Английский

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Therapeutic Uses, Chemical Compositions, With Special References to Oral Health Care, Market Values and Clinical Trial of Bee Propolis: An Updated Review

International Research Journal of Multidisciplinary Scope, Год журнала: 2024, Номер 05(01), С. 317 - 335

Опубликована: Янв. 1, 2024

Bee propolis is a natural ingredient seen in several floras such as poplar, palm, pine, conifer secretions, gums, resins, mucilage, and leaf buds.Propolis has numerous health benefits enhancing immunity, lowering blood pressure, treating allergies skin conditions; therefore, it widely used the prevention treatment of wide range disorders.Propolis subject interest current study because most people emphasize remedies with ethnopharmacological properties.Propolis considered by-product royal jelly known honey, which currently no credible information relating to its standardized production method well biological pharmacological activities around world.Propolis been therapeutically by humans for ages.Dental caries oral infections are treated propolis, due multifaceted chemical constituents like flavanones, pinocembrin, flavonols, galangin, caffeic acid, phenethyl ester, etc.This review article aims explore properties based on potential use general medical management.

Язык: Английский

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Usability of the phenolic profile analysis method developed in RP-HPLC-PDA in natural products

Journal of Apitherapy and Nature, Год журнала: 2024, Номер 7(1), С. 14 - 27

Опубликована: Июнь 30, 2024

The predominant majority of bioactive compounds in natural products are polyphenols. Reverse Phase High Performance Liquid Chromatography (HPLC) is the most employed analytical method for determining polyphenol profiles products. Analyses conducted based on methods validated according to number and type phenolic standards used. In this study, it was aimed determine 26 compound with HPLC-fotodiot array (PDA) detector, which preferred separation secondary metabolites commonly found analysis carried out utilizing a C18 column (250 mm x 4.6 mm, 5 μm; GL Sciences) gradient program. HPLC developed, limit detection within range 0.019-0.072 μg/mL, quantification 0.063-0.239 μg/mL. All calibration curves exhibited linear corelations R² values exceeding 0.994 across specified range. developed has been optimized by assessing limits, accuracy, repeatability, recovery data suitable analysis. It concluded that allows rapid reliable evaluation content their quantitative determination.

Язык: Английский

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Pulmonary Effects of Propolis

Опубликована: Янв. 1, 2024

Язык: Английский

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Antimicrobial, Anti-biofilm, Anti-swarming, Anti-quorum Sensing Activities, and Cytotoxicity of Propolis Samples from Northeast of Türkiye

Kastamonu University Journal of Forestry Faculty, Год журнала: 2024, Номер 24(2), С. 158 - 167

Опубликована: Май 8, 2024

Aim of study: Studies on propolis have increased as it has been revealed that contains biologically active molecules. In the current study, was aimed to analyze biological activity, and cytotoxicity ethanolic extract three different samples from Türkiye. Material methods: The antibacterial activity extracts against 14 microorganisms assessed using agar well diffusion method microdilution method. Chromobacter violeceum used in quorum-sensing assay, Pseudomonas aeruginosa PAO1 strain swarming biofilm assays. Using MTT test, cytotoxic effect examined lung adenocarcinoma cell line (A549), pancreatic tumoral (AR42J), breast cancer (MDA-MB-231), normal epithelial (Vero). Main results: All were effective 8/14 included study. While all shown anti-quorum sensing there not any anti-swarming anti-biofilm each sample. It demonstrated every sample had a dose-dependent lines. Research highlights: Due by is considered potential influence creation novel medications future.

Язык: Английский

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REVEALING THE MULTIFACETED LANDSCAPE OF PROPOLIS RESEARCH (1945-2023): A COMPREHENSIVE ANALYSIS OF DYNAMICITY, SPATIOTEMPORAL TRENDS, AND EMERGING PARADIGMS IN SCHOLARLY DISCOURSE

Uludağ Arıcılık Dergisi, Год журнала: 2024, Номер 24(2), С. 417 - 441

Опубликована: Ноя. 6, 2024

Propolis, a natural resinous substance produced by bees, has long been known for its potential health benefits. This study aims to present comprehensive bibliometric investigation, exploring the dynamicity, spatiotemporal trends, and emerging patterns in scholarly discourse surrounding propolis research. The tailed PRISMA guidelines used MeSH databases Scopus retrieve relevant bibliographic data spanning 75 years. R-based Bibliometrix VOSviewer applications were employed analysis. A noticeable increase production was observed last two decades. Active participation research identified from Brazil, China, Türkiye. multidimensional nature of evident through diversity topics covered highly impactful intellectual maps information sources. Thematic evolution highlighted dynamic research, with areas investigation an enhanced understanding therapeutic applications. Five prominent themes emerged: "propolis," "oxidative stress," "honey," "beeswax," "allergic contact dermatitis." Additionally, included chronic kidney disease, COVID-19, metabolomics. Mapping international cooperation co-citation authors demonstrated multiple activities. findings this hold implications researchers, healthcare professionals, policymakers, providing insights into current landscape

Язык: Английский

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Chemical profile, antioxidant, antifungal, and cytotoxic activities of propolis from the stingless bee Tetragona clavipes

Brazilian Journal of Microbiology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 13, 2024

Язык: Английский

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Chemical profiling and biological activity evaluation of propolis from Çayeli-Rize, Eastern Black Sea Region, Anatolia

Natural Product Research, Год журнала: 2024, Номер unknown, С. 1 - 10

Опубликована: Дек. 20, 2024

The constituents of the aqueous, ethanol, hexane, and methanol extracts Anatolian propolis collected from Eastern Black Sea Region (Çayeli-Rize) were investigated by GC–MS, HPLC AAS. Interestingly, lactulose has been identified. Ten phenolic compounds, namely caffeic acid, ferulic rutin, taxifolin, quercetin, kaempferol, apigenin, silicristin, silibinin gallic acid determined. contents acids flavonoids varied between 17.04–642.59 1.18–2749.20 ppm, respectively. Minerals found in Na, K, Ca, Mg Zn. extract had highest antiproliferative activity against A549 cell line with an IC50 value 0.1821 µL/mL. showed higher antibacterial Gram-negative bacteria compared to Gram-positive bacteria.

Язык: Английский

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