Nanomedicine in the treatment of Alzheimer’s disease: bypassing the blood-brain barrier with cutting-edge nanotechnology DOI
Nana Dong,

Payam Ali‐Khiavi,

Nima Ghavamikia

и другие.

Neurological Sciences, Год журнала: 2024, Номер unknown

Опубликована: Дек. 6, 2024

Язык: Английский

Polymer–Drug Conjugates Codeliver a Temozolomide Intermediate and Nitric Oxide for Enhanced Chemotherapy against Glioblastoma Multiforme DOI

Ke Du,

Xiao Li, Fude Feng

и другие.

ACS Applied Bio Materials, Год журнала: 2024, Номер 7(3), С. 1810 - 1819

Опубликована: Фев. 26, 2024

Polymer-drug conjugates (PDCs) provide possibilities for the development of multiresponsive drug delivery and release platforms utilized in cancer therapy. The Temozolomide (TMZ, a DNA methylation agent) by PDCs has been developed to improve TMZ stability under physiological conditions treatment glioblastoma multiforme (GBM); however, with inefficient chemotherapeutic efficacy. In this work, we synthesized an amphiphilic triblock copolymer (P1-SNO) four pendant functionalities, including (1) intermediate (named MTIC) as prodrug moiety, (2) disulfide bond redox-responsive trigger cage MTIC, (3) S-nitrosothiol light/heat-responsive donor nitric oxide (NO), (4) poly(ethylene glycol) chain enable self-assembly aqueous media. P1-SNO was demonstrated liberate MTIC presence reduced glutathione gaseous NO upon exposure light or heat. vitro results revealed synergistic effect released on both TMZ-sensitive TMZ-resistant GBM cells. environment-responsive PDC system codelivery is promising overcome efficacy issue TMZ-based

Язык: Английский

Процитировано

2
Evaluation of the Transport and Binding of Dopamine-Loaded PLGA Nanoparticles for the Treatment of Parkinson’s Disease Using In Vitro Model Systems DOI Creative Commons
Karin Danz,

Jana Fleddermann,

Marcus Koch

и другие.

Pharmaceutics, Год журнала: 2024, Номер 16(5), С. 571 - 571

Опубликована: Апрель 23, 2024

The treatment of Parkinson’s disease has been moving into the focus pharmaceutical development. Yet, necessity for reliable model systems in development phase made research challenging and vivo models necessary. We have established reliable, reproducible vitro to evaluate binding transport dopamine-loaded PLGA nanoparticles put results context with comparable results. provided similar concerning usability investigated as previously used thus provide a good alternative line 3R principles research.

Язык: Английский

Процитировано

2
STAT3 signaling in pancreatic ductal adenocarcinoma: a candidate therapeutic target DOI
Hussein Riyadh Abdul Kareem Al‐Hetty,

Sada Jasim Abdulameer,

Sami Awad Alkubaisy

и другие.

Pathology - Research and Practice, Год журнала: 2023, Номер 245, С. 154425 - 154425

Опубликована: Март 25, 2023

Язык: Английский

Процитировано

6
Intranasal delivery of Chitosan-based nanoparticles as an innovative way for management of neurodegenerative disorders: a comprehensive review of advanced strategies for CNS targeting DOI

Rabab M. Ibrahim,

Mahmoud H. Teaima, Mohamed A. El-Nabarawi

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 99, С. 105885 - 105885

Опубликована: Июль 1, 2024

Язык: Английский

Процитировано

1
Poly(alkyl cyanoacrylate): advancement as nano delivery systems DOI
Shruti Gupta,

Kiran Kumar Tejavath

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 253 - 265

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0
Nanomedicine in the treatment of Alzheimer’s disease: bypassing the blood-brain barrier with cutting-edge nanotechnology DOI
Nana Dong,

Payam Ali‐Khiavi,

Nima Ghavamikia

и другие.

Neurological Sciences, Год журнала: 2024, Номер unknown

Опубликована: Дек. 6, 2024

Язык: Английский

Процитировано

0