International Journal of Biomaterials,
Год журнала:
2023,
Номер
2023, С. 1 - 20
Опубликована: Дек. 30, 2023
Hand
sanitizer
usage
has
proven
to
be
a
common
and
practical
method
for
reducing
the
spread
of
infectious
diseases
which
can
caused
by
many
harmful
pathogens.
There
is
need
alcohol-free
hand
sanitizers
because
most
on
market
are
alcohol-based,
regular
use
them
damage
skin
hazardous.
India
world’s
largest
producer
fruits
one
major
problems
after
fruit
consumption
their
peels,
causing
waste
management
contributing
formation
greenhouse
gases
leading
air
pollution
adding
problem
climate
change.
Valorization
such
wastes
into
other
value-added
products
incorporation
formulations
eco-friendly
would
solve
these
issues,
save
environment,
benefit
society,
help
in
achieving
sustainable
development
goals.
Thus,
this
research
focuses
formulating
an
effective
natural
that
harnesses
antimicrobial
properties
various
types
bioactive
components
found
peels
pomegranate,
sweet
lime,
lemon.
The
peel
extracts
formulated
proved
considerable
activity
against
pathogenic
Escherichia
coli
microflora.
Molecular
docking
was
also
applied
examine
ligand-protein
interaction
patterns
predict
binding
conformers
affinity
phytocompounds
towards
target
proteins
COVID-19,
influenza,
pneumonia
viruses.
affinities
protein-ligand
interactions
virtual
studies
revealed
bind
with
amino
acids
proteins’
active
sites
via
hydrogen
bonding
interactions.
As
result,
it
possible
formulate
natural,
from
germs
viruses
using
basic
structure
potential
findings.
Molecules,
Год журнала:
2024,
Номер
29(3), С. 713 - 713
Опубликована: Фев. 4, 2024
Bergaptol
(5-hydroxypsoralen
or
5-hydroxyfuranocoumarin)
is
a
naturally
occurring
furanocoumarin
widely
found
in
citrus
fruits,
which
has
multiple
health
benefits.
Nonetheless,
no
specific
review
articles
on
bergaptol
have
been
published.
Compiling
updated
information
crucial
guiding
future
research
direction
and
application.
The
present
focuses
the
evidence
related
to
pharmacological
properties
toxicity
of
bergaptol.
anti-inflammatory,
antioxidant,
anti-cancer,
anti-osteoporosis,
anti-microbial,
anti-lipidemic
effects.
It
can
inhibit
activities
cytochrome
P450s
(CYP),
especially
CYP2C9
CYP3A4,
thereby
affecting
metabolism
concentrations
some
drugs
toxins.
Compared
with
other
coumarins,
least
potency
CYP3A4
cancer
cells.
Instead,
it
suppress
drug
efflux
transporters,
such
as
P-glycoprotein,
overcoming
chemotherapeutic
resistance.
Furthermore,
antimicrobial
effects
high
potential
for
inhibition
quorum
sensing.
In
vivo,
be
retained
plasma
longer
than
coumarins.
Nevertheless,
its
not
clearly
reported.
vitro
study
suggests
that,
unlike
most
furocoumarins,
phototoxic
photomutagenic.
Existing
mostly
conducted
vitro.
Further
vivo
clinical
studies
are
warranted
identify
safe
effective
doses
multimodal
Pharmacological Research - Modern Chinese Medicine,
Год журнала:
2024,
Номер
11, С. 100412 - 100412
Опубликована: Март 8, 2024
Doxorubicin
(DOX)
is
an
anthracycline
antibiotic
primarily
utilized
in
the
treatment
of
various
solid
tumors,
including
those
affecting
cervix,
ovaries,
breasts,
uterus,
lungs,
as
well
certain
blood
cancers.
However,
nephrotoxicity
connected
to
DOX
therapy
restricts
its
clinical
use.
In
Ancient
Chinese
Medicine
used
Lime
(Citrus.
aurantifolia)
Peel
was
employed
address
cramps,
colic
pain,
cold,
and
appetite
stimulant.
known
"Zhi
qiao"
Traditional
(TCM),
addition
nephroprotective,
antioxidant
immunostimulatory
properties
peel
had
been
noted
for
effectiveness
regulating
vital
energy,
treat
cough,
abdominal
distention
constipation.
The
purpose
this
research
evaluate
potential
protective
effect
Citrus
aurantifolia
extract
(CAPE)
alleviating
generated
by
doxorubicin
injection
rats.
Thirty
Wister
albino
rats
were
randomly
equally
separated
into
six
groups
(n
=
5),
they
treated
follows:
group
I
received
distilled
water
only
(baseline),
toxicant
administered
with
15
mg/kg,
i.p.
DOX,
24
hours
after,
II,
III
IV,
V
VI
(negative
control),
Alpha
lipoic
acid,
150
mg/kg
(positive
control)
100,
200
400
CAPE
respectively,
orally
seven
days.
caused
kidney
injury
after
a
single
intraperitoneal
injection,
shown
substantial
changes
biomarkers,
histological
irregularities,
reduction
defense
mechanisms
(reduced
glutathione,
superoxide
dismutase
catalase).
resulted
significant
improvements
amended
renal
biomarkers
(urea,
creatinine,
albumin
uric
acid),
haematological
parameters,
antioxidative
markers,
malondialdehyde.
present
findings
indicated
that
could
reduce
lipid
peroxidation
(LPO)
reactive
oxygen
species
production,
observable
supported
result.
Our
results
point
out
therapeutic
alternative
prevention
DOX-related
nephrotoxicity.
Applied Biological Chemistry,
Год журнала:
2024,
Номер
67(1)
Опубликована: Сен. 23, 2024
Abstract
Insecticidal
potential
of
extracts
Citrus
aurantifolia
,
family
Rutaceae,
was
evaluated
to
control
whiteflies,
Bemisia
tabaci
.
Biocidal
activity
directed
chromatographic
separation
chloroform
and
butanol
fractions,
with
spectral
identification
(1D-NMR,
2D-NMR,
ESIMS)
the
active
fractions
have
been
resulted
in
structural
elucidation
for
previously
described
coumarins
(bergapten
1
limettin
2
isopimpinellin
3
oxypeucedanin
hydrate
4
)
addition
a
new
dimeric
coumarin
(12R,
12’R)-aurantifolin
5
two
known
limonoids;
21,23-dihydro-23-methoxy-21-oxolimonin
6
21,23-dihydro-23-methoxy-21-oxonomilin
7
flavonoid
glycosides;
scoparin
8
narcissin
9
Amongst
these
compounds,
most
effective
after
24
h.
treatment
while,
potent
against
B.
3rd
instar
nymphs
72
under
laboratory
conditions,
LC
50
values
33.31and
15.92
ppm,
respectively
comparing
positive
azadirachtin.
Cosmetics,
Год журнала:
2023,
Номер
10(4), С. 108 - 108
Опубликована: Июль 21, 2023
With
the
increasing
number
of
cosmetic
consumers
emphasizing
value
consumption
and
sustainability,
upcycling
has
gained
attention
as
a
solution
to
agricultural
by-products,
which
are
main
culprits
environmental
problems.
In
this
study,
we
isolated
citrulluside
T
with
whitening
activity
from
discarded
Citrullus
lanatus
stems
investigated
anti-melanogenic
effect
underlying
mechanisms.
We
found
that
did
not
exhibit
cytotoxicity
up
concentration
90
μM
significantly
reduced
melanin
content
intracellular
tyrosinase
in
B16F10
cells.
addition,
inhibited
expression
melanogenic
enzymes
such
tyrosinase,
tyrosinase-related
protein
(TRP)-1,
TRP-2,
well
synthesis
via
cAMP-dependent
kinase
(PKA)/cAMP
response
element-binding
(CREB)-mediated
downregulation
microphthalmia-associated
transcription
factor
(MITF),
key
melanogenesis.
Furthermore,
exerted
its
by
downregulating
β-catenin
upregulating
phosphorylated
β-catenin.
Finally,
confirmed
was
safe
for
skin
through
irritation
tests
on
33
subjects,
suggesting
applicability
protective
agent
against
hyperpigmentation
topical
applications
cosmetics
ointments.
Pharmaceuticals,
Год журнала:
2024,
Номер
17(10), С. 1307 - 1307
Опубликована: Сен. 30, 2024
Drug
development
from
medicinal
plants
constitutes
an
important
strategy
for
finding
natural
anticancer
therapies.
While
several
plant
secondary
metabolites
with
potential
antitumor
activities
have
been
identified,
well-defined
mechanisms
of
action
remained
uncovered.
In
fact,
studies
often
focused
on
the
genome,
transcriptome,
and
proteome,
dismissing
relevance
metabolome
discovering
effective
plant-based
drugs.
Metabolomics
has
gained
huge
interest
in
cancer
research
as
it
facilitates
identification
uncovers
metabolomic
alterations
that
occur
cells
response
to
treatment.
This
holds
great
promise
investigating
mode
target
metabolites.
Although
metabolomics
made
significant
contributions
drug
discovery,
this
area
is
still
ongoing.
review,
we
emphasize
significance
research,
which
continues
be
a
technique
drugs
spite
all
challenges
encountered.
As
well,
provide
insights
into
essential
elements
required
performing
analyses.
Journal La Medihealtico,
Год журнала:
2024,
Номер
5(2), С. 408 - 417
Опубликована: Июнь 6, 2024
The
natural
human
environment
is
inhabited
by
various
organisms,
including
those
harmful
to
the
body
such
as
bacteria,
viruses,
fungi,
and
other
pathogens.
This
condition
weakens
immune
system's
response
pathogens,
making
more
susceptible
diseases
rheumatoid
arthritis,
cancer,
inflammations.
In
some
cases,
this
can
be
fatal,
leading
death.
study
aims
examine
immunomodulatory
effects
of
Ethanol
Extract
Lime
Peel
on
phagocytosis
activity
delayed-type
hypersensitivity
in
experimental
animals.
research
methods
include
sample
collection
processing,
plant
identification,
extract
preparation,
effect
testing.
Phytochemical
screening
results
showed
presence
alkaloids,
glycosides,
flavonoids,
tannins,
steroids
lime
peel.
Simplicia
ethanol
peel
characterization
yielded
meet
standards
Indonesian
Herbal
Pharmacopoeia
2nd
edition.
Immunomodulatory
testing
was
conducted
through
assays.
that
at
doses
25,
50,
100
mg/kgBW
had
immunostimulatory
enhancing
activity,
while
17.5
mg/kgBW,
35
70
significantly
increased
compared
negative
control.
These
findings
indicate
potential
Citrus
aurantifolia
an
immunomodulator
enhance
body's
system.
provides
important
contribution
development
therapy
derived
from
ingredients
for
managing
immunity-related
with
lower
side
effects.
