International Journal of Biomaterials,
Год журнала:
2023,
Номер
2023, С. 1 - 20
Опубликована: Дек. 30, 2023
Hand
sanitizer
usage
has
proven
to
be
a
common
and
practical
method
for
reducing
the
spread
of
infectious
diseases
which
can
caused
by
many
harmful
pathogens.
There
is
need
alcohol-free
hand
sanitizers
because
most
on
market
are
alcohol-based,
regular
use
them
damage
skin
hazardous.
India
world’s
largest
producer
fruits
one
major
problems
after
fruit
consumption
their
peels,
causing
waste
management
contributing
formation
greenhouse
gases
leading
air
pollution
adding
problem
climate
change.
Valorization
such
wastes
into
other
value-added
products
incorporation
formulations
eco-friendly
would
solve
these
issues,
save
environment,
benefit
society,
help
in
achieving
sustainable
development
goals.
Thus,
this
research
focuses
formulating
an
effective
natural
that
harnesses
antimicrobial
properties
various
types
bioactive
components
found
peels
pomegranate,
sweet
lime,
lemon.
The
peel
extracts
formulated
proved
considerable
activity
against
pathogenic
Escherichia
coli
microflora.
Molecular
docking
was
also
applied
examine
ligand-protein
interaction
patterns
predict
binding
conformers
affinity
phytocompounds
towards
target
proteins
COVID-19,
influenza,
pneumonia
viruses.
affinities
protein-ligand
interactions
virtual
studies
revealed
bind
with
amino
acids
proteins’
active
sites
via
hydrogen
bonding
interactions.
As
result,
it
possible
formulate
natural,
from
germs
viruses
using
basic
structure
potential
findings.
Abstract
Background
In
Thai
traditional
history,
Ya-Kao
(YK)
is
a
medicine
used
to
relieve
fever.
Several
folk
healers
have
recommended
the
use
of
YK
for
COVID-19
during
pre-treatment,
treatment,
and
post-treatment.
The
Department
Traditional
Alternative
Medicine
(DTAM)
has
accepted
COVID-19-infected
patients
been
observing
its
effectiveness
in
clinical
study.
Fourteen
plants
are
main
raw
materials
formula,
which
currently
lacks
scientific
information
support
properties.
study
aims
investigate
chemical
profile
biological
properties
by
measuring
antibacterial
anti-inflammatory
effects,
in
vitro
Methods
investigated
formula
based
on
plant
using
High-Performance
Thin
Layer
Chromatography
(HPTLC).
vitro,
activity
was
conducted
agar
disc
diffusion
TLC-bioautography.
nitric
oxide
(NO)
production
assay
RAW
264.7
macrophages
inflammatory
effect
induced
lipopolysaccharide
(LPS).
Results
This
successfully
explores
HPTLC
method
analyzing
quality
materials.
Whereas
pharmacological
property
examined.
YK-lime
juice
extract
exhibits
most
effective
against
both
gram-positive
gram-negative
bacteria.
addition,
methanolic
inhibited
Streptococcus
pyogenesKlebsiella
pnuemoniae
TLC-bioautography
method.
Furthermore,
extracts
methanol,
water,
lime
demonstrate
significant
properties,
evidenced
notable
reduction
NO
macrophage
model
LPS.
Conclusions
Overall,
these
data
could
YK,
medicine.
It
may
be
consumed
reduce
inflammation
co-infection
not
only
but
also
other
respiratory
infections.
BIO Web of Conferences,
Год журнала:
2023,
Номер
75, С. 01002 - 01002
Опубликована: Янв. 1, 2023
Research
on
the
potential
anticancer
effects
of
citrus
has
been
widely
published
in
scientific
journals.
Still,
a
bibliometric
analysis
concerning
this
topic
not
executed.
This
study
employed
mapping
to
analyze
articles
related
from
Scopus
Database
and
visualized
results
using
VOSviewer.
In
review,
442
papers
between
1995
2023
were
selected.
Jeju
National
University
South
Korea
is
recognized
as
top
contributor.
According
analysis,
apoptosis
are
two
specific
keywords
field
with
highest
co-occurrence.
The
other
selected
hesperidin,
naringenin,
nobiletin,
apoptosis,
flavonoids.
We
also
found
following
steps
research
area:
formulation,
synthesis,
vivo
preclinical
studies.
trends
have
shifted
crude
extract
practical
applications
flavonoid
compounds
structure
modification
improve
their
properties.
clinical
trials
humans
lacking
area
should
be
further
investigated
embrace
flavonoids
an
candidate.
provide
comprehensive
understanding
effect
citrus.
International Journal of Biomaterials,
Год журнала:
2023,
Номер
2023, С. 1 - 20
Опубликована: Дек. 30, 2023
Hand
sanitizer
usage
has
proven
to
be
a
common
and
practical
method
for
reducing
the
spread
of
infectious
diseases
which
can
caused
by
many
harmful
pathogens.
There
is
need
alcohol-free
hand
sanitizers
because
most
on
market
are
alcohol-based,
regular
use
them
damage
skin
hazardous.
India
world’s
largest
producer
fruits
one
major
problems
after
fruit
consumption
their
peels,
causing
waste
management
contributing
formation
greenhouse
gases
leading
air
pollution
adding
problem
climate
change.
Valorization
such
wastes
into
other
value-added
products
incorporation
formulations
eco-friendly
would
solve
these
issues,
save
environment,
benefit
society,
help
in
achieving
sustainable
development
goals.
Thus,
this
research
focuses
formulating
an
effective
natural
that
harnesses
antimicrobial
properties
various
types
bioactive
components
found
peels
pomegranate,
sweet
lime,
lemon.
The
peel
extracts
formulated
proved
considerable
activity
against
pathogenic
Escherichia
coli
microflora.
Molecular
docking
was
also
applied
examine
ligand-protein
interaction
patterns
predict
binding
conformers
affinity
phytocompounds
towards
target
proteins
COVID-19,
influenza,
pneumonia
viruses.
affinities
protein-ligand
interactions
virtual
studies
revealed
bind
with
amino
acids
proteins’
active
sites
via
hydrogen
bonding
interactions.
As
result,
it
possible
formulate
natural,
from
germs
viruses
using
basic
structure
potential
findings.
