A Review of Classification, Biosynthesis, Biological Activities and Potential Applications of Flavonoids

Molecules, Год журнала: 2023, Номер 28(13), С. 4982 - 4982

Опубликована: Июнь 25, 2023

Flavonoids represent the main class of plant secondary metabolites and occur in tissues organs various species. In plants, flavonoids are involved many biological processes response to environmental stresses. The consumption has been known reduce risk chronic diseases due their antioxidant free radical scavenging properties. present review, we summarize classification, distribution, biosynthesis pathways, regulatory mechanisms flavonoids. Moreover, investigated activities discuss applications food processing cosmetics, as well pharmaceutical medical uses. Current trends flavonoid research also briefly described, including mining new functional genes through omics engineering using nanotechnology. This review provides a reference for basic applied on compounds.

Язык: Английский

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Recent advances and applications of novel advanced materials in solid-phase microextraction for natural products

TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 178, С. 117858 - 117858

Опубликована: Июль 6, 2024

Язык: Английский

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Antimicrobial activities of natural flavonoids against foodborne pathogens and their application in food industry

Food Chemistry, Год журнала: 2024, Номер 460, С. 140476 - 140476

Опубликована: Июль 15, 2024

Язык: Английский

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Unveiling characteristic metabolic accumulation over enzymatic-catalyzed process of Tieguanyin oolong tea manufacturing by DESI-MSI and multiple-omics

Food Research International, Год журнала: 2024, Номер 181, С. 114136 - 114136

Опубликована: Фев. 19, 2024

Язык: Английский

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Epigallocatechin-3-gallate-induced tolerance to cadmium stress involves increased flavonoid synthesis and nutrient homeostasis in tomato roots

Plant Physiology and Biochemistry, Год журнала: 2024, Номер 208, С. 108468 - 108468

Опубликована: Март 1, 2024

Язык: Английский

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Nutraceutical Aspects of Selected Wild Edible Plants of the Italian Central Apennines

Nutraceuticals, Год журнала: 2024, Номер 4(2), С. 190 - 231

Опубликована: Апрель 9, 2024

All over the world, wild edible plants are an essential source of chemical components that justify their use in folk medicine. The aim this review is to document and summarize knowledge ten analyzed a previous study for ethnomedical significance. Achillea millefolium, Borago officinalis, Foeniculum vulgare, Gentiana lutea, Juniperus communis, Laurus nobilis, Malva sylvestris, Satureja montana, Silybum marianum Urtica dioica were subjects our study. They commonly found central Italian Apennines Mediterranean basin. Phytochemicals contained plants, such as phenols, polyphenols, flavonoids, condensed tannins, carotenoids, etc., receiving increasing attention, they exert wide range biological activities with resulting benefits human health. Based on 353 studies we reviewed, focused following: (a) ethnobotanical practices bioactive phytochemicals; (b) composition polyphenols role antioxidants; (c) methodologies used assess antioxidant activity; (d) most advanced spectroscopic spectrometric techniques visualize characterize all (metabolomic fingerprinting). potential pure compounds extracts be nutraceuticals has also been highlighted through supposed mechanism action.

Язык: Английский

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A necessary considering factor for crop resistance: Precise regulation and effective utilization of beneficial microorganisms

New Crops, Год журнала: 2024, Номер 1, С. 100023 - 100023

Опубликована: Апрель 15, 2024

Under global climate change circumstances, there has been growing acknowledgment of the critical need to prevent and manage both biotic abiotic stress in crops. Plants employ a variety signaling molecules, such as jasmonic acid (JA), abscisic (ABA), Ca2+, endure stress. Additionally, they utilize reactive oxygen species (ROS) detoxifiers while also harnessing assistance beneficial microorganisms, including Bacillus, Pseudomonas, Streptomyces, others. These microorganisms play pivotal role aiding crops management, albeit with certain limitations their efficacy. This article offers synthesis discourse on how can selectively engage via root systems, elucidating contributions these tolerance. Drawing upon current insights, we propose refined strategies for leveraging bolster crop resilience. By advancing our grasp plant-microorganism interactions judiciously selecting employing aim enhance dependability efficacy microbial products enhancing knowledge ultimately equips agricultural practitioners information needed make informed decisions adapting rapidly changing environmental conditions.

Язык: Английский

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Safflower CtFLS1-Induced Drought Tolerance by Stimulating the Accumulation of Flavonols and Anthocyanins in Arabidopsis thaliana

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(10), С. 5546 - 5546

Опубликована: Май 19, 2024

Flavonol synthase gene (FLS) is a member of the 2-oxoglutarate-dependent dioxygenase (2-ODD) superfamily and plays an important role in plant flavonoids biosynthetic pathways. Safflower (Carthamus tinctorius L.), key source traditional Chinese medicine, widely cultivated China. Although flavonoid pathway has been studied several model species, it still remains to be explored safflower. In this study, we aimed elucidate CtFLS1 biosynthesis drought stress responses. The bioinformatics analysis on showed that contains two FLS-specific motifs (PxxxIRxxxEQP SxxTxLVP), suggesting its independent evolution. Further, expression level safflower positive correlation with accumulation total content four different flowering stages. addition, CtFLS1-overexpression (OE) Arabidopsis plants significantly induced levels genes involved flavonol pathway. On contrary, anthocyanin pathway-related MYB transcription factors down-regulation. Furthermore, CtFLS1-OE promoted seed germination, as well resistance osmotic pressure drought, reduced sensitivity ABA compared mutant wild-type plants. Moreover, CtANS1 were both subcellularly located at cell membrane nucleus; yeast two-hybrid bimolecular fluorescence complementation (BiFC) assay they interacted each other membrane. Altogether, these findings suggest alleviating by stimulating flavonols

Язык: Английский

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Therapeutic potential of flavonoids in gastrointestinal cancer: Focus on signaling pathways and improvement strategies (Review)

Molecular Medicine Reports, Год журнала: 2025, Номер 31(4), С. 1 - 34

Опубликована: Фев. 24, 2025

Flavonoids are a group of polyphenolic compounds distributed in vegetables, fruits and other plants, which have considerable antioxidant, anti‑tumor anti‑inflammatory activities. Several types gastrointestinal (GI) cancer the most common malignant tumors world. A large number studies shown that flavonoids inhibitory effects on cancer, they recognized as class potential drugs. Therefore, present review investigated molecular mechanisms treatment different GI summarized drug delivery systems commonly used to improve their bioavailability. First, classification therapeutic various human diseases were briefly introduced. Then, clarify mechanism action body, metabolic process body associated signaling pathways causing five discussed, well corresponding targets flavonoids. Finally, clinical settings, poor water solubility, low permeability inferior stability, lead absorption efficiency vivo. three widely summarized. Suggestions for improving bioavailability focus next stage research also put forward.

Язык: Английский

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Metabolic diversity, biosynthetic pathways, and metabolite biomarkers analysed via untargeted metabolomics and the antioxidant potential reveal for high temperature tolerance in tomato hybrid

Plant Stress, Год журнала: 2024, Номер 11, С. 100420 - 100420

Опубликована: Март 1, 2024

High-temperature tolerant varieties/hybrids of tomato overcome stress-related changes due to their intrinsic cellular metabolic capabilities. We have used untargeted metabolite profiling and comparative biochemical biological analyses high temperature (HTT) hybrid VRNTH18283 sensitive (HTS) VRNTH19072 decipher altered pathways biomarker metabolites which were linked with enhanced antioxidant activity in HTT fruits. Parameters like fruit weight, yield per plant key determinants viz. total soluble sugar (TSS), titratable acidity, ascorbic acid lycopene content significantly compared HTS. Metabolomics revealed upregulated diversity extract (11453 m/z features) as 8834 features Statistical analysis 423 differentially up-regulated 410 down-regulated features. Multivariate data showed sample discrimination based on distinct phytochemical diversification. Functionally annotated enrichment including linoleic linolenic metabolism, monoterpenoids biosynthesis degradation, cutin, suberin wax biosynthesis, sphingolipids metabolism. Metabolite categorized benzamides, amino acids, sugars, nucleotides, sterols, glycosides, phenylacetaldehydes, indoles, tryptamines organic acids major compound classes. Among 22 potentially discriminatory obtained from OPLS-DA model, all prominently abundant solasodine, thiamine diphosphate, L-tryptophan, folic acid, lycopene, dihydrozeatin, myricetin, tomatidine, chlorogenic α-tocotrienol classified biomarkers correlated activity. The study that the physicochemical profile, increased compositional are liable for improved performance against negative impact comparison HTS VRNTH19072.

Язык: Английский

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