Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Ноя. 11, 2024
Human
melanoma
is
linked
with
aging-related
disorders,
prompting
interest
in
the
development
of
functional
foods
derived
from
natural
ingredients
to
mitigate
its
incidence.
Molecules
green
seaweeds
such
as
Caulerpa
racemosa
can
serve
this
purpose
due
their
anti-tumor
and
anti-inflammatory
properties.
A
previous
work
study
compounds
profiling
has
been
carried
out,
research
molecular
docking
studies
targeting
receptors
associated
(GRP78,
IRE1,
BRAF)
aging
(mTOR,
AMPK,
SIRT1)
identified
four
promising
compound
an
extract
C.
racemosa.
The
current
aims
mechanism
those
at
a
cellular
level
using
human
A375
(BRAF-V600E
mutation)
B16-F10
cell
lines.
MTT
assay
was
used
evaluate
potential
GSCRE
against
lines,
comparisons
made
normal
HDFa
Results
indicated
that
C2,
also
known
Caulersin,
demonstrated
significantly
different
∆G
affinity
binding
score
compared
control
drug
Dabrafenib.
crude
extract,
particularly
showed
modulating
mTOR,
SIRT1
pathways
downregulating
GRP78,
BRAF
signaling
(p
<
0.05).
Interestingly,
C2
less
effective
suppressing
lines
(LD
Phytotherapy Research,
Год журнала:
2024,
Номер
38(8), С. 4053 - 4080
Опубликована: Июнь 19, 2024
Abstract
In
2022,
there
were
around
20
million
new
cases
and
over
9.7
cancer‐related
deaths
worldwide.
An
increasing
number
of
metabolites
with
anticancer
activity
in
algae
had
been
isolated
identified,
which
promising
candidates
for
cancer
therapy.
Red
are
well‐known
the
production
brominated
metabolites,
including
terpenoids
phenols,
have
capacity
to
induce
cell
toxicity.
Some
non‐toxic
biological
macromolecules,
polysaccharides,
distinct
secondary
found
many
algae,
particularly
green
algae.
They
possess
activities
by
inhibiting
tumor
angiogenesis,
stimulating
immune
response,
inducing
apoptosis.
However,
structure–activity
relationship
between
these
components
antitumor
activity,
as
well
certain
taxa
within
remains
relatively
unstudied.
This
work
is
based
on
reports
published
from
2003
2024
PubMed
ISI
Web
Science
databases.
A
comprehensive
review
characterized
algal
active
compounds,
together
their
structure
mechanism
action
was
performed.
Also,
preliminarily
summarized
better
assess
potential
properties
a
natural,
safe
bioactive
product
be
used
an
alternative
treatment
cancers,
leading
opportunities
drug
discovery.
Marine Drugs,
Год журнала:
2025,
Номер
23(2), С. 70 - 70
Опубликована: Фев. 7, 2025
In
recent
years,
the
exploration
of
bioactive
molecules
derived
from
natural
sources
has
gained
interest
in
several
application
fields.
Among
these,
macroalgae
have
garnered
significant
attention
due
to
their
functional
properties,
which
make
them
interesting
therapeutic
applications,
including
cancer
treatment.
Cancer
constitutes
a
global
health
burden,
and
side
effects
existing
treatment
modalities
underscore
necessity
for
novel
models
that,
line
with
goal
reducing
drug
treatments,
take
advantage
compounds.
This
review
explores
anticancer
properties
macroalgae,
focusing
on
compounds
mechanisms
action.
The
key
findings
suggest
that
possess
rich
array
compounds,
polysaccharides
(e.g.,
fucoidans
alginates),
polyphenols
phlorotannins),
terpenoids,
exhibit
diverse
activities,
such
as
inhibition
cell
proliferation,
angiogenesis,
induction
apoptosis,
modulation
immune
system.
provides
an
overview
current
understanding
macroalgae’s
potential,
highlighting
most
promising
While
preclinical
studies
shown
results,
further
research
is
necessary
translate
these
into
effective
clinical
applications.
RSC Advances,
Год журнала:
2025,
Номер
15(6), С. 4708 - 4767
Опубликована: Янв. 1, 2025
The
work
provides
a
systematic
and
critical
overview
of
the
cutting-edge
research
on
SPs
hybrid
sulfated
polysaccharide
bio-nanocomposites
identifies
key
factors,
mechanisms,
methods,
challenges
impacting
bio-nanocomposites.
Comprehensive Reviews in Food Science and Food Safety,
Год журнала:
2024,
Номер
23(4)
Опубликована: Июнь 21, 2024
Abstract
The
development
of
future
food
is
devoted
not
only
to
obtaining
a
sustainable
supply
but
also
providing
high‐quality
foods
for
humans.
Plant‐derived
non‐starch
polysaccharides
(PNPs)
are
widely
available,
biocompatible,
and
nontoxic
have
been
largely
applied
the
industry
owing
their
mechanical
properties
biological
activities.
PNPs
considered
excellent
biomaterials
ingredients
contributing
development.
However,
comprehensive
review
potential
applications
in
has
reported.
This
summarized
physicochemical
activities
then
discussed
structure–activity
relationships
PNPs.
Latest
studies
on
including
cell‐cultured
meat,
special
medical
purposes
(FSMPs),
three‐dimensional‐printed
were
reviewed.
challenges
prospects
critically
proposed.
with
strong
thermal
stability
good
thickeners,
emulsifiers,
gelatinizers
that
greatly
improve
processing
adaptability
foods.
decellularized
plant‐based
make
them
desirable
scaffolds
cultured
meat
manufacturing.
In
addition,
exhibit
multiple
health‐promoting
effects;
therefore,
can
act
as
producing
FSMP
promote
human
health.
Three‐dimensional
printing
technology
enhances
structures
functional
foods,
which
favor
expanding
application
scopes
food.
promising
manufacturing,
more
efforts
need
be
made
realize
commercial
applications.
Starch - Stärke,
Год журнала:
2024,
Номер
76(9-10)
Опубликована: Март 19, 2024
Abstract
Diabetic
nephropathy
is
a
serious
metabolic
disease
that
usually
caused
by
diabetes
mellitus
and
ends
in
chronic
kidney
renal
failure.
Many
drugs
used
to
treat
diabetic
have
limitations
side
effects.
There
an
urgent
need
find
safe
effective
new
for
the
treatment
of
nephropathy.
The
polysaccharides
from
natural
sources,
including
plants,
fungi,
algae,
good
protective
effects
on
without
In
this
paper,
chemical
composition,
structural
characteristics
are
reviewed.
addition,
study
summarizes
different
mechanisms
improve
nephropathy,
such
as
antioxidative
stress,
regulation
inflammation,
inhibition
apoptosis,
fibrosis.
This
review
provides
theoretical
support
effect
reveals
potential
therapeutic
methods
