Industrial & Engineering Chemistry Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 20, 2024
Achieving
the
maximum
production
rate
of
a
chemical
component
in
process
requires
an
optimal
design
and
operating
strategy.
One
possible
approach
toward
this
goal
is
elementary
function
(EPF)
optimization
where
temperature,
pressure,
mass
flow
profiles
for
Lagrangian
fluid
element
are
determined.
In
current
study,
EPF
methodology
applied
to
reductive
amination
long-chain
aldehydes
microemulsion
systems
(MES)
maximize
reaction
performance.
These
solvent
multiphase
green
chemistry
combine
highly
selective
homogeneous
catalysis
with
excellent
catalyst
retention
using
water
phase.
For
MES,
cyclic
semibatch
operation
selected
as
best
approximation
trajectories.
This
new
concept
implemented
modular
mini-plant,
successful
validation
results
achieved
19
consecutive
reactions
during
125
h
mini-plant
campaign.
The
yield
(43.8
±
3.3)
%,
selectivity
(64.3
5.4)
conversion
(68.0
3.4)
%
higher
than
those
previous
CSTR.
Especially,
strong
increase
selectivity,
through
suppression
side
product
formation,
proves
that
calculation
can
lead
better
99.1%
entering
settler
recycled
reactor,
performance
remains
constant
without
requiring
additional
catalyst.
long-term
stability
support
studies,
which
outline
large
potential
media
their
readiness
implementations.
Chemical Science,
Год журнала:
2024,
Номер
15(24), С. 9016 - 9025
Опубликована: Янв. 1, 2024
Initial
calculations
of
environmental
footprints
associated
with
using
Ni
vs
Pd
catalysis
in
a
representative
metal-catalyzed
Suzuki–Miyaura
cross-coupling
reveal
that
the
choice
ligated
metal
is
often
NOT
consequence.
Rather,
it
culmination
other
parameters
such
as
medium.
Organic Process Research & Development,
Год журнала:
2024,
Номер
28(4), С. 816 - 830
Опубликована: Март 14, 2024
From
the
context
of
sustainability,
contemporary
synthetic
organic
chemistry
practices
require
significant
transformation,
as
indicated
by
various
sustainability
matrices
like
atom
economy,
process
mass
intensity
(PMI),
E-factor,
and
DOZN.
These
factors
have
evidently
unveiled
inherent
inefficiencies
intrinsic
to
conventional
protocols
identified
solvents
principal
causative
agent.
In
response,
utilization
water
a
primary
reaction
medium
for
transformations
has
emerged
an
appealing
alternative.
This
approach
flourished
with
emergence
micellar
catalysis,
where
amphiphilic
molecules
alter
bulk
aqueous
medium's
solvation
properties
promote
desired
chemical
transformation
under
milder
sustainable
conditions.
After
2010,
this
technology
gained
considerable
momentum
established
foundational
framework
performing
reactions
conditions,
consequently
mitigating
dependency
on
hazardous
solvents.
perspective,
recent
advances
in
field
catalysis
will
be
discussed
industrial
applications,
along
future
directions
challenges
associated
regime.
Substitution
of
one
metal
catalyst
for
another
is
not
straightforward
as
simply
justifying
this
change
based
on
the
availability
and/or
cost
metals.
A
life
cycle-like
assessment
was
performed
leading
to
conclusion
that
commonly
held
view
use
earth-abundant
metals
(and
in
case
study,
Ni)
are
replacements
palladium
most
notably
cross
coupling
reactions,
and
Suzuki-Miyaura
couplings,
particular,
an
incomplete
analysis
entire
picture.
This
notion
can
be
misleading,
unfortunately
derives
nowadays
mainly
from
standpoint
cost,
some
degree,
relative
natural
abundance
mining
impact
each
metal.
However,
a
more
realistic
appreciation
emerges
when
several
additional
reaction
parameters
involved
couplings
considered.
Such
unequivocally
points
major
climate
brought
about
by
organic
solvents,
while
actually
play
subordinate
roles
terms
CO2-release
into
environment.
Clearly,
study
reveals
factors
contribute
various
ways
overall
carbon
footprint.
Hence,
far
detailed
required
than
typically
being
utilized!
Green Chemistry,
Год журнала:
2024,
Номер
26(3), С. 1393 - 1398
Опубликована: Янв. 1, 2024
Herein,
we
report
a
commercially
available
natural
saponin
acting
as
surfactant
and
serving
micellar
catalyst,
enabling
Suzuki–Miyaura
cross-coupling
effectively
with
highly
challenging
heteroaromatic
substrates
in
water
at
room
temperature.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 24, 2025
Synthesis
of
water-stable
and
dispersible
heterogeneous
catalysts
having
high
catalytic
efficiency
is
more
challenging
compared
with
homogeneous
due
to
their
low
dispersity,
activity,
spatial
confinement
active
centers
in
bulk
water.
Herein,
we
are
describing
systematic
studies
for
the
development
microconfinement
participation
aqueous
micelles
via
temporal
surface
modification
porous
organic
polymer
derived
from
phosphine
ligands.
Detailed
investigations
using
various
techniques
such
as
transmission
electron
microscopy
(TEM),
scanning
(SEM),
tensiometry,
confocal
laser
(CLSM),
fluorescence
lifetime
imaging
(FLIM)
have
been
used
understand
role
micelles,
reagents,
materials
generation
microcolonies
Two-color
crossover
experiments
also
performed
exchange
reagents
or
vice
versa,
materials.
The
surfactant-modified
ligation
stabilization
palladium,
which
was
evidenced
by
high-resolution
(HR-TEM),
high-angle
annular
dark-field
(HAADF-STEM),
X-ray
photoelectron
spectroscopy
(XPS)
analysis.
act
confined
space
catalysis
water
showcasing
Suzuki-Miyaura
cross-coupling
reaction
a
ppm
level
Pd
loading
under
mild
conditions.
catalyst
found
be
recyclable
five
cycles;
easy
scale-up
C-C
couplings
additional
features.
Moreover,
these
data
provide
an
opportunity
revising
models
micellar
systems
that
underpin
sustainable
