Biomaterials Advances, Год журнала: 2025, Номер 171, С. 214228 - 214228
Опубликована: Фев. 11, 2025
Язык: Английский
Journal of Cancer Research and Clinical Oncology, Год журнала: 2024, Номер 150(4)
Опубликована: Апрель 25, 2024
Abstract Copper is a necessary micronutrient for maintaining the well-being of human body. The biological activity organic ligands, especially their anticancer activity, often enhanced when they coordinate with copper(I) and (II) ions. its compounds are capable inducing tumor cell death through various mechanisms action, including activation apoptosis signaling pathways by reactive oxygen species (ROS), inhibition angiogenesis, induction cuproptosis, paraptosis. Some copper complexes currently being evaluated in clinical trials ability to map hypoxia cancers, locally advanced rectal cancer bulky tumors. Several studies have shown that nanoparticles can be used as effective agents chemodynamic therapy, phototherapy, hyperthermia, immunotherapy. Despite promising copper-based compounds, use subject certain limitations. Elevated concentrations may promote growth, metastasis affecting cellular processes.
Язык: Английский
Процитировано
23
Cancers, Год журнала: 2024, Номер 16(3), С. 647 - 647
Опубликована: Фев. 2, 2024
Copper, an essential element for various biological processes, demands precise regulation to avert detrimental health effects and potential cell toxicity. This paper explores the mechanisms of copper-induced death, known as cuproptosis, its disease implications, including cancer therapy. Copper ionophores, such elesclomol disulfiram, increase intracellular copper levels. elevation triggers oxidative stress subsequent offering implications in Additionally, ionophores disrupt mitochondrial respiration protein lipoylation, further contributing toxicity death. Potential targets biomarkers are identified, can be targeted those proteins trigger cuproptosis. The role different cancers is discussed understand therapies using nanomaterials, chelators. Furthermore, explored through diseases Wilson Menkes physiological copper. Exploring cuproptosis presents opportunity improve treatments copper-related disorders cancers, with bring significant advancements modern medicine.
Язык: Английский
Процитировано
22
Ceramics International, Год журнала: 2024, Номер 50(20), С. 38281 - 38292
Опубликована: Июль 18, 2024
Язык: Английский
Процитировано
18
Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(11), С. 2670 - 2690
Опубликована: Янв. 1, 2024
HKUST-1 represents a promising biomaterial, functioning not only as drug carrier but also releasing bioactive copper ions, thereby demonstrating exceptional antitumor, antibacterial, and wound healing properties.
Язык: Английский
Процитировано
17
Deleted Journal, Год журнала: 2025, Номер unknown
Опубликована: Янв. 23, 2025
Gold-coated nanoparticles have garnered significant attention in recent years due to their exceptional thermal stability and distinct optical properties. This paper investigates the characteristics of various nanoparticles, including Silica, Gold, Silica using Mie theory, Gan's effective medium approach. Plasmonic been extensively studied for medical applications across scientific fields. Their surface plasmon resonance remarkable ability absorb scatter light revolutionized diagnosis, treatment, assessment numerous diseases, particularly cancer. One valuable these linked plasmonic properties, is use photothermal therapy cancer treatment. Nanoparticle-based phototherapy has emerged as one most treatment methods years, owing its high efficiency destroying cancerous tumors while minimizing side effects.
Язык: Английский
Процитировано
2
Talanta, Год журнала: 2024, Номер 280, С. 126790 - 126790
Опубликована: Авг. 29, 2024
Язык: Английский
Процитировано
13
Nano-Structures & Nano-Objects, Год журнала: 2024, Номер 37, С. 101105 - 101105
Опубликована: Фев. 1, 2024
Язык: Английский
Процитировано
12
Journal of Functional Biomaterials, Год журнала: 2024, Номер 15(9), С. 241 - 241
Опубликована: Авг. 23, 2024
The rising demand for effective bone regeneration has underscored the limitations of traditional methods like autografts and allografts, including donor site morbidity insufficient biological signaling. This review examines nanoparticles (NPs) in tissue engineering (TE) to address these challenges, evaluating polymers, metals, ceramics, composites their potential enhance osteogenesis angiogenesis by mimicking extracellular matrix (ECM) nanostructure. involved synthesizing characterizing nanoparticle-based scaffoldsand integrating hydroxyapatite (HAp) with polymers mechanical properties osteogenic potential. results showed that NPs significantly promote cell growth, differentiation, formation, carbon-based graphene carbon nanotubes showing promise. offer versatile, biocompatible, customizable scaffolds drug delivery support repair. Despite promising results, challenges cytotoxicity, biodistribution, immune responses remain. Addressing issues through surface modifications biocompatible molecules can improve biocompatibility efficacy nanomaterials. Future research should focus on long-term vivo studies assess safety NP-based explore synergistic effects other bioactive or growth factors. underscores transformative advancing BTE calls further optimize technologies clinical applications.
Язык: Английский
Процитировано
11
Environmental Technology Reviews, Год журнала: 2025, Номер 14(1), С. 94 - 126
Опубликована: Фев. 16, 2025
Язык: Английский
Процитировано
1
Applied Surface Science, Год журнала: 2024, Номер 670, С. 160642 - 160642
Опубликована: Июль 4, 2024
Язык: Английский
Процитировано
6