Health-Related Messages About Herbs, Spices, and Other Botanicals Appearing in Print Issues and Websites of Legacy Media: Content Analysis and Evaluation (Preprint)

Опубликована: Июнь 14, 2024

Legacy media are publications that existed before the internet. Many of these have migrated to a web format, either replacing or in parallel their print issues. Readers place an economic value on access information presented as they pay for subscriptions and higher degree trust content. Much has been written about inaccurate misleading health social media; however, content accuracy contained legacy not examined detail. Discussion herbs, spices, other botanicals absent from this context. The objectives study were (1) identify associations botanical products mentioned targeted range demographic groups (2) evaluate against published scientific studies. In total, 10 popular magazines targeting gender, race/ethnicity, sexual orientation selected analysis. Relevant was extracted coded over 1 year. Associations between specific factors identified. For most frequent botanical–health application associations, PubMed search conducted reviews corresponding each item’s indicated applications. Where no systematic available, single research studies sought. A total 237 unique There 128 mentions issues 1215 websites. 18 applications identified used categorize uses various individually general categories. frequently skin care, with 913 mentions, immunity enhancement, 705 gastrointestinal probiotics, 184 cognitive function (stress mental health), 106 mentions. Comparison literature evaluating efficacy functions positive support aloe vera, argan oil, chamomile, jojoba lavender, rosemary, tea tree oil care. Berries, ginger, turmeric, green had strongest evidence role enhancement. Ginger oats supported having health. Finally, berries, ashwagandha, cannabidiol managing stress. Other items such mushrooms less strongly supported. prevalent indicates that, overall, consistent current reports products. While some greater than others, truly egregious falsehoods absent. Therefore, may be considered credible source readers topics.

Язык: Английский

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Withaferin A inhibits Chikungunya virus nsP2 protease and shows antiviral activity in the cell culture and mouse model of virus infection

PLoS Pathogens, Год журнала: 2024, Номер 20(12), С. e1012816 - e1012816

Опубликована: Дек. 30, 2024

Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus causing fever, myalgia, and debilitating joint swelling pain, which in many patients becomes chronic. The frequent epidemics of CHIKV across the world pose significant public health burden necessitating development effective antiviral therapeutics. A cellular imaging-based high-content screening natural compounds identified withaferin (WFA), steroidal lactone isolated from plant Withania somnifera, as potent against CHIKV. In ERMS cells, WFA inhibited replication early during life cycle by binding non-structural protein nsP2 inhibiting its protease activity. This viral polyprotein processing minus-sense RNA synthesis. mounted inhibitory activity through oxidising property reducing agents N-acetylcysteine Glutathione-monoethyl ester effectively reversed WFA-mediated inhibition vitro abolished cultured cells. C57BL/6 mouse model chikungunya disease, resulting significantly lower viremia. Importantly, CHIKV-infected mice showed was not seen WFA-treated mice. These data demonstrate potential novel antiviral.

Язык: Английский

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Immune-stimulating and antioxidant properties of a traditional Algerian plant combination: Date fruit (Phoenix dactylifera) and Fenugreek seeds (Trigonella foenum-graecum)

The North African Journal of Food and Nutrition Research, Год журнала: 2024, Номер 8(18), С. 253 - 261

Опубликована: Дек. 5, 2024

Background: Combinatory therapy involving medicinal plants utilizes blends of different species to enhance therapeutic efficacy, increase potency, and minimize adverse effects. This approach leverages the synergistic interactions plant-derived bioactive compounds, offering a natural holistic strategy for addressing various health conditions. Aims: study aimed evaluate effects traditional Algerian combination date fruit (Phoenix dactylifera) fenugreek seeds (Trigonella foenum-graecum) on phagocytic activity hepatic glutathione (GSH) levels. Materials Methods: Phagocytic was measured using carbon clearance rate test, while levels were determined spectrophotometrically from liver homogenates. Results: The results demonstrated that both GSH significantly enhanced in animals treated with plant (p < 0.001). faster mice receiving combined treatment (FG “Fenugreek” / PD “Phoenix dactylifera”: 14.66 ± 4.143) compared NaCl control group (49.77 16.98). Additionally, index higher FG (7.128 0.823) groups either alone (FG: 4.082 0.306) or (PD: 4.87 0.608). Hepatic also elevated other = 0.040). Conclusions: exhibits synergic effect, enhancing immune system antioxidant capacity. These findings suggest its potential development novel, naturally derived agents. Keywords: activity, fruit, seeds, GSH, therapy.

Язык: Английский

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Antioxidant and immunomodulatory activities of the ethanolic extract of Eugenia jambolana Lam. root bark assessed using in vitro and in vivo methods

Journal of Herbmed Pharmacology, Год журнала: 2024, Номер 14(1), С. 112 - 119

Опубликована: Дек. 25, 2024

Introduction: Natural products are a rich source of antioxidants, effective on immunological disorders. The present study was planned to evaluate the antioxidant activity ethanolic extract root bark an Indian medicinal plant, Eugenia jambolana, by in vitro methods and immunomodulatory vivo methods. Methods: collected E. jambolana (EJE) prepared tested for using concentrations 10-50 µg/mL through 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical superoxide anion scavenging assays. Further, effects EJE were assessed animal studies against experimental antigen, sheep RBC, oral administration at doses 100, 200, 400 mg/kg, measuring its impact antibody titer values antigen-antibody reaction paw thickness mice (delayed-type hypersensitivity [DTH] study) humoral cell-mediated immune responses, respectively. Results: exhibited properties DPPH radicals with IC50 43.79 ± 0.24 47.64 0.18 respective studies. mg/kg dose demonstrated significant (P<0.05) value DTH response These showed that produced 29.36% 39.06% immunity studies, Conclusion: experiments this potential bark.

Язык: Английский

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Evaluation of Herbal Anticoccidials on Growth Performance in Experimentally Infected Broiler Chickens

Agriculture, Год журнала: 2024, Номер 14(12), С. 2261 - 2261

Опубликована: Дек. 10, 2024

Avian diseases, especially coccidiosis, represent a significant threat to poultry production, demanding research into the use of herbal supplements in birds’ diets. So, aim this study was assess efficacy selected components mitigating coccidiosis broilers and examine their overall impact on productivity traits broilers. A 35-day feeding trial conducted with 1200 male ROSS 308 broiler chickens two facilities, one non-infected, using either usual coccidiostats (UC−) or 500 g/t additive (consisting Holarrhena antidysenterica, Ficus religiosa, Berberis aristata, Allium sativum, Embelia ribes, Azadirachta indica; HA−) other intentionally exposed Eimeria via drinking water at 7 days old, corresponding control experimental groups (UC+ HA+). Dietary interventions significantly influenced chicken body weight (BW) average daily gain (ADG) throughout trial, notably day 21, UC+ treatment yielding highest values. Herbal did not affect feed conversion ratio (FCR) liveability. Under infection, litter dry matter (DM) content differences were notable 14 favouring treatments (HA− also impacted presence duodenum jejunum between treatments. Despite several limitations, reveals that additions may effectively manage infection enhance quality since demonstrated improved development anatomy.

Язык: Английский

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