1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane (DOI): From an Obscure to Pivotal Member of the DOX Family of Serotonergic Psychedelic Agents – A Review
ACS Pharmacology & Translational Science,
Год журнала:
2024,
Номер
7(6), С. 1722 - 1745
Опубликована: Май 8, 2024
1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane
(DOI,
or
DOX
where
X
=
−I)
was
first
synthesized
in
1973
a
structure–activity
study
to
explore
the
effect
of
various
aryl
substituents
on
then
newly
identified,
and
subsequently
controlled,
hallucinogenic
agent
1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane
(DOM,
−CH3).
Over
time,
DOI
found
be
serotonin
(5-HT)
receptor
agonist
using
peripheral
5-HT
tissue
assays
later,
following
identification
multiple
families
central
receptors,
an
at
5-HT2
receptors
rat
and,
then,
human
brain.
Today,
classical
hallucinogens,
currently
referred
as
serotonergic
psychedelic
agents,
are
receiving
considerable
attention
for
their
potential
therapeutic
application
neuropsychiatric
disorders
including
treatment-resistant
depression.
Here,
we
review,
historical
current
developments
that
led
becoming
unique,
perhaps
landmark,
research.
Язык: Английский
Treatment-resistant depression: molecular mechanisms and management
Molecular Biomedicine,
Год журнала:
2024,
Номер
5(1)
Опубликована: Окт. 17, 2024
Due
to
the
heterogeneous
nature
of
depression,
underlying
etiological
mechanisms
greatly
differ
among
individuals,
and
there
are
no
known
subtype-specific
biomarkers
serve
as
precise
targets
for
therapeutic
efficacy.
The
extensive
research
efforts
over
past
decades
have
not
yielded
much
success,
currently
used
first-line
conventional
antidepressants
still
ineffective
close
66%
patients.
Most
clinicians
use
trial-and-error
treatment
approaches,
which
seem
beneficial
only
a
fraction
patients,
with
some
eventually
developing
resistance.
Here,
we
review
evidence
from
both
preclinical
clinical
studies
on
pathogenesis
depression
antidepressant
response.
We
also
discuss
efficacy
pharmacological
non-pharmacological
well
novel
emerging
therapies.
reveals
that
in
response,
specific,
but
rather
involve
an
interplay
between
various
neurotransmitter
systems,
inflammatory
mediators,
stress,
HPA
axis
dysregulation,
genetics,
other
psycho-neurophysiological
factors.
None
current
hypotheses
sufficiently
accounts
interactional
involved
its
etiology
could
partly
explain
limited
success
discovering
efficacious
treatment.
Effective
management
treatment-resistant
(TRD)
requires
targeting
several
mechanisms,
using
and/or
personalized
modalities,
could,
example,
include
multi-target
pharmacotherapies
augmentation
psychotherapy
approaches.
Future
guided
by
interaction
provide
more
insights
into
potential
etiologies
TRD,
precision
biomarker
targets,
modalities.
Язык: Английский
The immunomodulatory effects of classical psychedelics: A systematic review of preclinical studies
Progress in Neuro-Psychopharmacology and Biological Psychiatry,
Год журнала:
2024,
Номер
unknown, С. 111139 - 111139
Опубликована: Сен. 1, 2024
Язык: Английский
Investigating the causal relationship between inflammation and multiple types of hearing loss: a multi-omics approach combining Mendelian randomization and molecular docking
Jingqi Zhang,
Tao Guo,
Yaxin Chen
и другие.
Frontiers in Neurology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 28, 2024
Background
Hearing
loss
affects
over
10%
of
the
global
population.
Inflammation
is
a
key
factor
in
hearing
caused
by
noise,
infection,
and
aging,
damaging
various
hearing-related
tissues
(e.g.,
spiral
ligament,
stria
vascularis).
Mendelian
randomization
(MR)
can
help
identify
potential
causal
relationships
therapeutic
targets.
Methods
We
conducted
MR
analyses
on
91
inflammatory
proteins
(
n
=
14,824)
genome-wide
association
study
results
for
types
European
ancestry
populations,
including
sensorineural
(SNHL;
cases
15,952,
controls
196,592),
sudden
idiopathic
(SIHL;
1,491,
other
(OHL;
4,157,
196,592).
Additionally,
with
difficulty
14,654,
474,839)
served
as
validation
set.
To
predict
protein-enriched
pathways
tissues,
we
performed
enrichment
analysis,
functional
annotation,
tissue
using
“OmicsNet2.0”
“FUMA”
platforms.
also
combined
“CoreMine”
molecular
docking
to
explore
drugs
targeting
investigate
binding
efficacy.
Results
CCL19
was
identified
common
risk
SNHL
OHL,
which
validated
dataset.
Tissue
analysis
revealed
that
SIHL-related
were
enriched
amygdala.
Multi-omics
research
indicated
associations
between
neurodegenerative
diseases.
Molecular
studies
suggested
Chuanxiong
Rhizoma
Uncariae
Ramulus
Cumuncis
are
CCL19.
Conclusion
This
through
highlighting
crucial
role
loss.
The
related
amygdala
their
diseases
provide
new
insights
into
mechanisms
Язык: Английский