The relaxation effect of Ethanolic Extract of Temu Putih (Curcuma zedoaria) on the Histamine-1 Receptor in Isolated Guinea Pigs Tracheal
Research Journal of Pharmacy and Technology,
Год журнала:
2025,
Номер
unknown, С. 212 - 216
Опубликована: Янв. 27, 2025
Asthma
is
among
the
most
prevalent
non-communicable
diseases
worldwide,
affecting
approximately
235
million
individuals,
primarily
children.
The
major
risk
factors
for
asthma
include
genetic
predisposition
to
certain
airborne
allergens
and
environmental
exposure
these
allergens.
To
manage
asthma,
therapies
often
involve
relaxing
respiratory
tract's
smooth
muscles
by
counteracting
effect
of
phosphodiesterase
activity,
which
normally
induces
muscle
constriction.
This
enzyme
also
lowers
calcium
levels
phosphorylating
contractile
proteins.
Herbal
treatments
are
frequently
used
as
complementary
with
many
key
deriving
from
herbs,
such
B2-agonists,
anticholinergics,
methylxanthines,
chromones.
study
aimed
determine
if
white
turmeric
could
alleviate
contraction
in
isolated
tracheal
triggered
acetylcholine
an
organ
bath
setting.
found
that
ethanol
extract
Temu
Putih
(EETP),
contains
flavonoids,
was
effective
reducing
guinea
pig
trachea
induced
atropine
sulphate
at
a
concentration
1
x
10-6
M.
Moreover,
alone
compared
its
when
incubated
EETH
showed
significant
difference
(p
<
0.05),
suggesting
inhibition
PDE
responsible
muscle-relaxing
properties.
Язык: Английский
Coffea canephora var. Robusta Modulates Testosterone and CRISP-1 Levels in STZ-Induced Diabetic Rats
Research Journal of Pharmacy and Technology,
Год журнала:
2025,
Номер
unknown, С. 739 - 743
Опубликована: Фев. 27, 2025
Diabetes
mellitus
is
a
metabolic
disorder
characterized
by
hyperglycemia,
oxidative
stress,
and
inflammation,
which
can
lead
to
various
complications,
including
alterations
in
reproductive
function.
In
this
study,
we
aimed
investigate
the
effect
of
Coffea
canephora
var.
Robusta
ethanol
extract
on
testosterone
cysteine-rich
secretory
protein-1
(CRISP-1)
levels
streptozotocin
(STZ)-induced
diabetic
rats.
Male
Wistar
rats
were
divided
into
five
groups:
control,
diabetic,
treated
with
at
three
different
doses
(100,
200,
400mg/kg
body
weight).
After
four
weeks
treatment,
serum
CRISP-1
measured.
The
results
showed
that
STZ-induced
diabetes
significantly
decreased
increased
expression
compared
control
group.
However,
treatment
all
Furthermore,
highest
dose
(400mg/kg)
exhibited
most
significant
effect.
These
findings
suggest
may
have
therapeutic
potential
regulating
rats,
could
implications
for
management
diabetes-associated
complications.
Further
studies
are
needed
elucidate
underlying
mechanisms
evaluate
long-term
effects
its
Язык: Английский
Seagrass Meadows: Prospective Candidates for Bioactive Molecules
Molecules,
Год журнала:
2024,
Номер
29(19), С. 4596 - 4596
Опубликована: Сен. 27, 2024
Seagrass
meadows
consist
of
angiosperms
that
thrive
fully
submerged
in
marine
environments
and
form
distinct
ecosystems.
They
provide
essential
support
for
many
organisms,
acting
as
nursery
grounds
species
economic
importance.
Beyond
their
ecological
roles,
seagrasses
associated
microbiomes
are
rich
sources
bioactive
compounds
with
the
potential
to
address
numerous
human
healthcare
challenges.
Seagrasses
produce
molecules
responding
physical,
chemical,
biological
environmental
changes.
These
activities
can
treat
microbe-borne
diseases,
skin
diabetes,
muscle
pain,
helminthic
wounds.
also
offer
secondary
metabolites
be
used
societal
benefits.
Despite
results
on
presence
derivatives,
only
a
few
studies
have
explored
functional
therapeutic
properties
from
seagrass.
With
increasing
spread
epidemics
pandemics
worldwide,
demand
alternative
drug
discovery
has
become
an
indispensable
area
research.
present
reliable
natural
source,
making
this
opportune
moment
further
exploration
pharmacological
minimal
side
effects.
This
review
provides
comprehensive
overview
biochemical,
phytochemical,
biomedical
applications
globally
over
last
two
decades,
highlighting
prospective
areas
future
research
identifying
applications.
Язык: Английский
Exploring Nanoherbal Tomato: Assessing its Potential as an α-Glucosidase and α-Amylase Inhibitor, Antioxidant and Metabolite Profiling using LC-HRMS
Research Journal of Pharmacy and Technology,
Год журнала:
2024,
Номер
unknown, С. 4953 - 4960
Опубликована: Окт. 22, 2024
Nanoherbal
Tomato
(NT)
presents
a
compelling
avenue
for
exploring
its
multifaceted
potential
in
the
realms
of
metabolic
regulation
and
antioxidative
effects.
In
this
study,
NT
was
characterized
by
particle
size
(936
±
112.4
nm)
subjected
to
LC-HRMS
metabolite
profiling,
unveiling
key
compounds
such
as
ellagic
acid,
hexadecanamide,
dibenzylamin,
myricetin,
kaempferol,
various
carotenoids.
To
assess
therapeutic
potential,
evaluated
α-glucosidase
α-amylase
inhibition
capabilities.
exhibited
promising
inhibitory
activity
with
an
IC50
value
51.62
µg/mL,
surpassing
standard
drug
acarbose
(78.1
µg/mL).
Similarly,
assay,
demonstrated
competitive
62.31
μg/mL,
closely
aligned
that
(58.56
μg/mL).
These
findings
underscore
natural
agent
control.
Furthermore,
study
delves
into
properties
NT.
DPPH
scavenging
significant
antioxidant
48.281
µg/mL.
The
exploration
opens
avenues
NT's
utility
mitigating
oxidative
stress-related
conditions
enhancing
overall
health.
also
encompasses
determination
total
phenolic
content
(TPC)
flavonoid
(TFC)
Results
revealed
high
values
TPC
(300.21
15.20
mg
GAE/g)
TFC
(20.78
1.82
QE/g)
NT,
reflecting
rich
composition.
summary,
comprehensively
examines
size,
profile,
activities,
content.
shed
light
on
positioning
it
candidate
therapy.
Further
research
clinical
investigations
are
warranted
fully
harness
Tomato.
Язык: Английский
Antidiabetic Activity of Nano herbal Extract of Ocimum basilicum L on Rat Induced Streptozotocin
Research Journal of Pharmacy and Technology,
Год журнала:
2024,
Номер
unknown, С. 6107 - 6111
Опубликована: Дек. 27, 2024
Background:
antihyperglycemic
effects
of
a
nanoherbal
formulation
derived
from
Ocimum
basilicum
L
in
managing
Diabetes
Mellitus
(DM),
growing
global
health
concern.
With
DM
cases
projected
to
rise
sharply,
this
experimental
research
is
timely,
especially
Indonesia
which
has
high
prevalence
undiagnosed
diabetes.
Materials
And
Methods:
In
the
study,
seven
groups
rats
(each
with
five
weighing
200-250
grams)
were
utilized:
normal
group,
negative
control
positive
group
treated
metformin,
and
four
varying
doses
(25,
50,
100,
200
mg/kg
body
weight).
The
diabetic
state
was
induced
using
combination
Streptozotocin
(STZ)
Nicotinamide
(NCT),
elevating
blood
glucose
levels
above
mg/dL.
Results:
results
promising.
Superoxide
dismutase
(SOD)
levels,
an
indicator
oxidative
stress,
highest
receiving
weight
dose
treatment,
surpassing
even
metformin
group.
Similarly,
insulin
most
elevated
matching
suggesting
substantial
antidiabetic
effect.
Malondialdehyde
(MDA)
marker
lipid
peroxidation,
decreased
significantly
nearly
restoring
values.
Conclusion:
These
findings
highlight
potential
tomato-based
as
therapeutic
option
for
diabetes
management.
However,
mechanisms
action
human
application
require
further
investigation.
Язык: Английский