Molecules, Год журнала: 2024, Номер 29(21), С. 5054 - 5054
Опубликована: Окт. 26, 2024
Microorganisms and plants, particularly medicinal herbs, are abundant sources of diverse natural products, many which bioactive molecules with significant pharmaceutical or health benefits, include artemisinin [...]
Язык: Английский
Frontiers in Microbiology, Год журнала: 2024, Номер 15
Опубликована: Окт. 8, 2024
As the global male infertility rate continues to rise, there is an urgent imperative investigate underlying causes of sustained deterioration in sperm quality. The gut microbiota emerges as a pivotal factor host health regulation, with mounting evidence highlighting its dual influence on semen. This review underscores interplay between Testis-Gut axis and consequential effects sperm. Potential mechanisms driving impact encompass immune modulation, inflammatory responses mediated by endotoxins, oxidative stress, antioxidant defenses, microbiota-derived metabolites, epigenetic modifications, regulatory sex hormone signaling. Interventions such probiotics, prebiotics, synbiotics, fecal transplantation, Traditional natural herbal extracts are hypothesized rectify dysbiosis, offering avenues modulate enhance Spermatogenesis motility. Future investigations should delve into elucidating foundational principles governing interaction within Axis. Understanding modulating Axis may yield novel therapeutic strategies fertility combat decline
Язык: Английский
Процитировано
5
Pharmacological Research, Год журнала: 2025, Номер 214, С. 107694 - 107694
Опубликована: Март 10, 2025
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2025, Номер 15
Опубликована: Янв. 20, 2025
Acute lung injury (ALI) is a common respiratory disease, Cordycepin has been reported to reduce ALI, which an effective component in Cordyceps militaris solid medium extract (CMME). Therefore, we aimed explore the alleviating effect and mechanism of CMME on ALI. This study evaluated lipopolysaccharide (LPS)-induced ALI mice by analyzing intestinal flora metabolomics its potential mechanism. We assessed pulmonary changes, inflammation, oxidative stress, macrophage neutrophil activation levels, then analyzed gut microbiota through 16S rRNA profile UPLC-QTOF/MS. The results showed that treatment improved injury, reduced inflammatory factors stress decreased recruitment. revealed significantly increased richness diversity abundance Bacteroides compared with Mod group significantly. Metabolic analysis indicated reversed levels differential metabolites may ameliorate purine metabolism, nucleotide bile acid (BA) did reverse changes BA mice, were associated flora. improve regulating correcting metabolic disorders, providing new insights into action.
Язык: Английский
Процитировано
0
J — Multidisciplinary Scientific Journal, Год журнала: 2024, Номер 7(3), С. 351 - 372
Опубликована: Сен. 4, 2024
The discovery of natural products has been pivotal in drug development, providing a vast reservoir bioactive compounds from various biological sources. This narrative review addresses critical research gap: the largely underexplored role gut microbiota mediation and biotransformation medicinal herb-derived for therapeutic use. By examining interplay between products, this highlights potential microbiota-mediated to unveil novel agents. It delves into mechanisms by which microbes modify enhance efficacy with focus on herbal medicines Ayurveda traditional Chinese medicine, known their applications treating metabolic inflammatory diseases. also discusses recent advances microbiota-derived product research, including innovative methodologies such as culturomics, metagenomics, metabolomics. exploring intricate interactions microorganisms substrates, uncovers new strategies leveraging processes development groundbreaking therapeutics.
Язык: Английский
Процитировано
2
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 8769 - 8769
Опубликована: Авг. 12, 2024
Exposure to the space microenvironment has been found disrupt homeostasis of intestinal epithelial cells and alter composition microbiota. To investigate this in more detail examine impact ginsenoside Rb1, we utilized a mouse model hindlimb unloading (HU) for four weeks simulate effects microgravity. Our findings revealed that HU mice had ileum injury with decrease number stem (ISCs) level cell proliferation. The niche functions ISCs were also impaired mice, including reduction Paneth Wnt signaling, along an increase oxidative stress. administration Rb1 during entire duration alleviated observed defects, suggesting its beneficial influence on homeostasis. Hindlimb resulted gut dysbiosis. supplementation or addition derivative compound K bacterial culture vitro promoted growth probiotic species such as Akkermansia. co-housing experiment further showed treatment ground control alone could alleviate defects co-housed Rb1-treated mice. Together, these results underscore close relationship between dysbiosis ISC model. It highlights mitigating HU-induced by promoting expansion probiotics. These animal-based insights provide valuable knowledge development improved approaches maintaining astronauts.
Язык: Английский
Процитировано
1
Food & Function, Год журнала: 2024, Номер 15(18), С. 9037 - 9052
Опубликована: Янв. 1, 2024
The occurrence and progression of mild cognitive impairment (MCI) are closely related to dysbiosis the gut microbiota. Ginsenoside compound K (CK), a bioactive component ginseng, has been shown alleviate microbiota neural damage. However, mechanisms by which CK regulates improve MCI remain unexplored. In this study, an mouse model induced D-galactose was used, 16S rRNA gene sequencing, metabolomics, transcriptomics, integrative multi-omics analyses were employed investigate potential alleviates through modulation results demonstrated that repaired intestinal barrier dysfunction caused MCI, improved blood-brain (BBB) integrity, inhibited activation microglial cells astrocytes, significantly ameliorated MCI. Furthermore, enhanced diversity, notably enriched beneficial bacteria such as
Язык: Английский
Процитировано
1
RSC Advances, Год журнала: 2024, Номер 14(37), С. 27354 - 27364
Опубликована: Янв. 1, 2024
This investigation delves into the daucosterol-lecithin complex (DS-LC) and its effects on lipid homeostasis in hyperlipidemic mice. DS-LC was assessed for complexation efficiency, physicochemical properties (UV, XRD, FTIR, SEM, DSC), impact organ health serum levels. The results revealed that daucosterol formed an effective with lecithin at a 2 : 1 ratio, producing translucent beige distinctive aggregation. UV-vis spectra confirmed daucosterol's chromophore structure remained intact DS-LC, indicating no new compound formation. FTIR analysis identified hydrogen bonding increased molecular association without changing peaks, highlighting specific intermolecular interactions. SEM XRD showed transformed irregular form within matrix, forming phase demonstrating strong lecithin-daucosterol interaction. Thermal suggested homogeneous distribution due to treatment effectively alleviated hyperlipidemia, enhancing liver function reducing accumulation epididymal fat. It also significantly decreased total cholesterol, triglycerides, LDL-C, arteriosclerosis index mice, DS-LC's potential as therapeutic agent metabolism related metabolic disorders.
Язык: Английский
Процитировано
1
Food Research International, Год журнала: 2024, Номер 197, С. 115141 - 115141
Опубликована: Сен. 26, 2024
Язык: Английский
Процитировано
1
Molecules, Год журнала: 2024, Номер 29(21), С. 5054 - 5054
Опубликована: Окт. 26, 2024
Microorganisms and plants, particularly medicinal herbs, are abundant sources of diverse natural products, many which bioactive molecules with significant pharmaceutical or health benefits, include artemisinin [...]
Язык: Английский
Процитировано
0