Semiconductors, Год журнала: 2024, Номер 58(12), С. 1027 - 1048
Опубликована: Дек. 1, 2024
Язык: Английский
Journal of Macromolecular Science Part B, Год журнала: 2025, Номер unknown, С. 1 - 12
Опубликована: Янв. 9, 2025
Colon cancer is still a significant cause of cancer-related deaths and, therefore, new treatment approaches are required. As naturally derived polysaccharide, Chitosan has become one the most promising materials in polymer-based drug delivery systems because its outstanding biocompatibility, biodegradability, and pH-responsive release. This review explores expanding roles chemical modifications colon therapy, emphasizing relationship between macromolecular interactions structure-property dynamics. Recent progress Chitosan-based nanocarriers, including nanoparticles, nanogels hybrid systems, highlights their potential to overcome multidrug resistance minimize off-target toxicity. These advancements closely aligned with developments precision medicine, incorporating stimuli-responsive components targeted ligands for enhanced efficacy. While preclinical clinical studies yield results, critical challenges such as scalability, reproducibility regulatory compliance remain obstacles translation. emphasizes transformative addressing therapeutic barriers treatment. Looking ahead, future should focus on utilizing cutting-edge technologies, artificial intelligence 3D bioprinting, enhance formulations develop personalized solutions that more effective tailored individual needs.
Язык: Английский
Процитировано
1
OpenNano, Год журнала: 2024, Номер 21, С. 100220 - 100220
Опубликована: Ноя. 13, 2024
Язык: Английский
Процитировано
5
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Molecules, Год журнала: 2024, Номер 29(13), С. 3117 - 3117
Опубликована: Июнь 30, 2024
The prevalence of major bacterial infections has emerged as a significant menace to human health and life. Conventional treatment methods primarily rely on antibiotic therapy, but the overuse these drugs led decline in their efficacy. Moreover, bacteria have developed resistance towards antibiotics, giving rise emergence superbugs. Consequently, there is an urgent need for novel antibacterial agents or alternative strategies combat infections. Nanoantibiotics encompass class nano-antibacterial materials that possess inherent antimicrobial activity can serve carriers enhance drug delivery efficiency safety. In recent years, metal nanoclusters (M NCs) gained prominence field nanoantibiotics due ultra-small size (less than 3 nm) distinctive electronic optical properties, well biosafety features. this review, we discuss progress M NCs new generation agents. First, main synthesis characteristics are presented. Then, focus reviewing various detecting treating pathogenic using NCs, summarizing effects wound infections, biofilms, oral Finally, propose perspective remaining challenges future developments infectious therapy.
Язык: Английский
Процитировано
3
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 282, С. 136715 - 136715
Опубликована: Окт. 23, 2024
Язык: Английский
Процитировано
2
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 9889 - 9919
Опубликована: Сен. 1, 2024
With the in-depth knowledge of pathological and physiological characteristics intestinal barrier-portal vein/intestinal lymphatic vessels-systemic circulation axis, oral targeted drug delivery is frequently being renewed. many advantages, such as high safety, convenient administration, good patient compliance, researchers have begun to explore from intravenous injections administration. Over past few decades, fields materials science nanomedicine produced various platforms that hold great potential in overcoming multiple barriers associated with delivery. However, transport particles into systemic extremely difficult due immune rejection biochemical invasion intestine, which limits absorption entry bloodstream. The feasibility drugs sites outside gastrointestinal tract (GIT) unknown. This article reviews biological absorption, vivo fate mechanisms carriers, theoretical basis for impact carrier structural evolution on administration achieve this goal. Finally, different nano-delivery systems can enhance bioavailability therapeutics highlights their applications efficient creation anticancer nanomedicines.
Язык: Английский
Процитировано
1
Polymers for Advanced Technologies, Год журнала: 2024, Номер 36(1)
Опубликована: Дек. 26, 2024
ABSTRACT Numerous issues and concerns are associated with current cancer therapeutics, such as multidrug resistance tumors, drug toxicity, severe side effects, financial burden. Phytocompounds from plants have garnered significant interest alternatives adjunct therapies to mitigate these effects owing their safety, efficacy, cost‐effectiveness. As demonstrated by a number of preclinical clinical investigations, phytocompounds combinations doxorubicin mediate anticancer modulating multiple signaling pathways linked immune system mobilization, apoptosis promotion, inhibition excessive cellular proliferation. However, continue encounter challenges related inadequate bioavailability, pharmacokinetics, metabolism. To address challenges, the utilization different types nanoparticles has become in nanomedicine for targeted delivery, enhancing retention time, reducing toxicity. This field study showcases remarkable amalgamation nanotechnology chemo‐drugs (doxorubicin). Thus, this review focuses on recent developments nanocarriers based delivery systems, particularly those intended simultaneous chemotherapy medicines, synthesizing existing knowledge filling research gaps. also discussed combined therapy chemotherapeutic drugs other nanotechnology‐based carriers treatment.
Язык: Английский
Процитировано
1
Semiconductors, Год журнала: 2024, Номер 58(12), С. 1027 - 1048
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
1