Nanoparticles in wastewater: a comprehensive approach to understanding their ecotoxicity and genotoxicity

Desalination and Water Treatment, Год журнала: 2025, Номер unknown, С. 100988 - 100988

Опубликована: Янв. 1, 2025

Язык: Английский

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Glucose Reduced Nano-Se Mitigate Cu-Induced ROS by Upregulating Antioxidant Gene in Zebrafish Larvae

Nanoscale Advances, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

This study compares the therapeutic efficiency of bovine serum albumin-stabilized selenium nanoparticles in reducing oxidative stress and improving cellular health. The were synthesized using mussel-extracted with two agents: d-glucose orange. Inductively coupled plasma-optical emission spectroscopy X-ray diffraction analyses confirmed presence selenium. agent duration influenced nanoparticle size. Reduction for 1 hour revealed that particles exhibited an average size 10 nm. Copper sulfate-induced malformations such as yolk sac pericardial edema observed 25 μg ml-1 orange-reduced nanoparticles, while d-glucose-reduced mitigated these at ml-1. Treatment stabilized Se-NPs reduced 30 minutes showed 33% dose-dependent radical scavenging activities, upregulated approximately 2-fold superoxide dismutase, catalase, glutathione reductase, peroxidase encoding genes restored homeostasis by decreasing lipid peroxidation (27.32 nmol mg-1 ml-1) nitric oxide levels (6.71 μM). They also had potential to restore cognitive properties larval movement (93.40 m) without altering behaviour. Live cell imaging indicated a significant decrease reactive oxygen species gut liver. These findings suggest are promising candidates stress-induced neurodegeneration.

Язык: Английский

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Nanoparticle-Mediated Embryotoxicity: Mechanisms of Chemical Toxicity and Implications for Biological Development

Chemical Research in Toxicology, Год журнала: 2025, Номер unknown

Опубликована: Март 19, 2025

Nanoparticles, defined by their nanoscale dimensions and unique physicochemical properties, are widely utilized in healthcare, electronics, environmental sciences, consumer products. However, increasing evidence of potential embryotoxic effects during pregnancy underscores the need for a molecular-level understanding interactions embryonic development. Nanoparticles such as titanium dioxide, silver, cerium oxide, copper quantum dots can cross placental barrier interfere with crucial developmental processes. At molecular level, they disrupt signaling pathways like Wnt Hedgehog, induce oxidative stress inflammation, cause genotoxic effects, all critical sensitive phases, organogenesis. Furthermore, these nanoparticles interact directly cellular components, including DNA, proteins, lipids, impairing function viability. Innovative strategies to mitigate nanoparticle toxicity, surface modifications incorporation biocompatible coatings, discussed solutions reduce adverse interactions. Various laboratory animal models used investigate nanoparticle-induced embryotoxicity evaluated efficacy limitations, providing insights into applicability effects. This Account examines mechanisms which compromise development emphasizes importance designing safer minimize maternal-fetal exposure risks, particularly biomedical applications.

Язык: Английский

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Are food-derived carbon dots really edible? A potential harm versus potential benefits analysis

Trends in Food Science & Technology, Год журнала: 2025, Номер unknown, С. 105031 - 105031

Опубликована: Апрель 1, 2025

Язык: Английский

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Comparison of the effects of copper oxide nanoparticles (CuO-NPs) and copper (II) sulfate on oxidative stress parameters in rainbow trout hatchlings ( Oncorhynchus mykiss )

The European Zoological Journal, Год журнала: 2024, Номер 91(2), С. 897 - 905

Опубликована: Июль 2, 2024

Язык: Английский

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Toxicology of Nanomaterials With a Special Focus on the Nervous System

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Год журнала: 2024, Номер unknown, С. 27 - 64

Опубликована: Окт. 11, 2024

Nanomaterials possess different properties that make them suitable for application in numerous fields. Nonetheless, their toxicity, especially neurotoxic propensity, is a considerable area of investigation. In this chapter, nanomaterial neurotoxicity reviewed detail, with an emphasis on assessing levels exposure or routes entry to brain cells, mechanisms by which they cause damage, and specific types damage. addition, vitro, ex vivo, vivo models used measure are described. This chapter provides discussion matter considering challenges terms characterization, risk assessment, regulatory aspects. concludes underscoring the importance toxicological prediction safe-by-design solutions. Future research should address long-term effects using nanomaterials means preventing neurotoxicity.

Язык: Английский

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Inulin Improves the Redox Response in Rats Fed a Diet Containing Recommended Copper Nanoparticle (Cunps) Levels While Pectin or Psyllium in Rats Receiving Excessive Cunps Levels in the Diet

Опубликована: Янв. 1, 2024

Язык: Английский

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