Dihydroartemisinin suppresses COX-2-mediated apoptosis resistance in hepatocellular carcinoma under endoplasmic reticulum stress
Cytotechnology,
Год журнала:
2025,
Номер
77(2)
Опубликована: Фев. 13, 2025
Язык: Английский
Editorial: Drugs and methods that enhance the anti-cancer efficacy of artesunate
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Март 17, 2025
Ferroptosis,
a
regulated
cell
death
mechanism
triggered
by
iron-dependent
lipid
peroxidation,
has
emerged
as
promising
target
in
cancer
therapy.
This
process
is
distinct
from
other
forms
of
death,
such
apoptosis,
necrosis,
and
autolysis,
due
to
its
unique
morphological
biochemical
characteristics.
The
high
iron
demand
susceptibility
cells
ferroptosis
make
this
particularly
advantageous
addressing
drug
resistance
metastasis.
Liu
et
al.
have
explored
the
role
therapy
metastasis,
detailing
molecular
mechanisms
associated
with
potential
overcoming
preventing
metastasis
(Liu
al.).Several
studies
shown
that
reduced
sensitivity
leads
(9,10).
Conversely,
inducing
been
found
enhance
efficacy
standard
chemotherapy,
targeted
therapies,
radiotherapy,
immunotherapy
(11,12).
Furthermore,
biological
processes
epithelial-mesenchymal
transition
(EMT)
noncoding
RNAs
regulate
ferroptosis,
thereby
influencing
(13)(14)(15).
In
context,
targeting
represents
crucial
strategy
for
both
spread
re-sensitizing
resistant
therapy.As
an
antimalarial
drug,
artesunate
recently
gained
attention
researchers
effects
on
(16,17).
Artesunate
triggers
increasing
ROS
production
disrupting
metabolism
(17,18).
Particularly
ferroptosis-sensitive
types,
cytotoxic
are
further
enhanced
when
combined
treatments
platinum-based
drugs,
paclitaxel,
temozolomide
(19)(20)(21).The
extends
beyond
resistance.
It
also
capacity
inhibit
metastatic
cells.
For
example,
suppressing
EMT
production,
offers
significant
advantage
cells.While
ferroptosis-based
offer
strategies
treatment,
development
therapeutic
approaches
requires
innovative
designs
diversify
efficacy.
regard,
combining
different
pharmacophores
provides
novel
pathway
address
fundamental
challenges
selective
toxicity.
Pharmacophore
hybrids
represent
tools
not
only
complement
existing
treatment
but
expand
clinical
benefits
current
multiple
pathways
while
sparing
healthy
tissues.The
combination
active
advantages,
including
modulation
targets,
efficacy,
prevention
development,
reduction
side
effects.
Dong
designed
synthesized
15
dihydroartemisinin
isatin
derivatives
three-carbon
linker,
demonstrating
their
potent
anti-lung
activity.
These
were
extensively
tested
against
drug-sensitive
(A549),
doxorubicin-resistant
(A549/DOX),
cisplatin-resistant
(A549/DDP)
lung
lines
(Dong
al.).Biological
evaluations
revealed
6a
6e
exhibited
comparable
IC50
values
doxorubicin
cisplatin
lines.
non-toxic
profile
normal
epithelial
highlighted
selectivity.
Notably,
hybrid
displayed
demonstrated
good
stability
mouse
human
microsomes
superior
pharmacokinetic
properties,
making
it
candidate
preclinical
studies.The
study
underscores
developing
pharmacophore
solutions
enhancing
They
anticipated
hold
place
future
applications.In
study,
Lin
discussed
diverse
activities
artemisitin
(ATT),
natural
compound
isolated
Artemisia
annua
L.
analogue
artemisinin.
ATT,
identified
endoperoxide,
promise
diseases
inflammation,
oxidative
stress,
cancer.
instance,
ATT
bind
cysteine
residues
Keap1
protein,
stabilize
Nrf2,
reduce
stress-induced
damage.
Additionally,
reported
NLRP3
inflammasome
activation,
inflammatory
processes.
context
anticancer
effects,
induce
NEDD4/c-Myc/topoisomerase
pathways,
tumor
growth.
However,
unclear
proteins
remain
barrier
application.
emphasize
identifying
ATT's
critical
structural
optimization
elucidation
pharmacological
mechanisms.
Ma
comprehensively
investigated
(ART)
choroidal
melanoma
(CM)
using
network
pharmacology,
docking,
experimental
validation.
addressed
limited
options
poor
prognosis
CM,
highly
malignant
ocular
tumor.Artesunate,
broad-spectrum
antitumor
properties.
ART
targets
pharmacology
key
apoptosis
induction,
cycle
arrest,
stress
regulation.
Molecular
docking
confirmed
ART's
strong
binding
ability
these
pathways.Experimental
validation
supported
ART.
vitro
experiments
induced
via
p53
signaling
pathway,
inhibited
PI3K/AKT/mTOR
arrest
at
G0/G1
phase,
increased
levels
activate
NRF2/HO-1
pathway.
findings
corroborated
vivo
studies,
which
showed
suppression
CM
growth
ART.The
was
proposed
interfere
migration
through
interactions
MMP2
MMP9,
play
roles
extracellular
matrix
degradation
metastasis.In
conclusion,
presented
compelling
evidence
multifaceted
oncogenic
promoting
arresting
cycle,
levels.
highlight
agent
paving
way
strategies.The
scope
artemisinin
malaria
offering
opportunities
managing
complex
like
molecules
create
integration
into
strategies.
scientific
journey,
bridging
traditional
knowledge
modern
biotechnological
innovation,
demonstrates
profound
outcomes
can
arise
synthesis.
Successfully
translating
applications
challenges,
delivery
systems,
mechanisms,
improvement
formulation
bioavailability
Moreover,
deeper
understanding
clarification
safety
profiles
essential
ensure
effective
safe
implementation.
expected
pivotal
more
therapies.
Язык: Английский
Multidimensional regulation of transcription factors: decoding the comprehensive signals of plant secondary metabolism
Frontiers in Plant Science,
Год журнала:
2025,
Номер
16
Опубликована: Март 26, 2025
Plants
synthesize
an
extensive
array
of
secondary
metabolites
in
response
to
diverse
biotic
and
abiotic
stresses.
These
function
not
only
as
defensive
compounds
but
also
constitute
significant
sources
nutrition
pharmaceuticals.
However,
the
mechanisms
governing
synthesis
these
have
long
been
a
central
focus
research
continue
pose
challenges.
Transcription
factors
(TFs),
serving
key
regulators
metabolite
plants,
exhibit
action
that
are
still
fully
understood.
This
review
summarizes
latest
advancements
on
how
plant
transcription
mediate
regulation
biosynthesis
through
various
signaling
pathways,
including
light
signaling,
hormone
MAPK
ubiquitin-proteasome
pathway,
epigenetic
regulation,
microbial
interactions,
climate
change.
A
deeper
understanding
regulating
is
expected
provide
new
insights
into
metabolites.
Язык: Английский
New Roles of Artemisinins in Atherosclerosis Progression
Phytotherapy Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 8, 2025
ABSTRACT
Artemisinin
is
a
natural
compound
derived
from
the
Chinese
plant
Artemisia
annua
,
which
was
officially
approved
by
FDA
for
its
antimalarial
effects.
In
recent
years,
growing
body
of
studies
has
shown
novel
function
artemisinin
in
atherosclerosis
therapy.
vivo
have
that
can
inhibit
progression
plaque.
present
review,
evidence
showing
inhibitory
effects
on
plaque
and
underlying
mechanisms
discussed.
Mechanistically,
derivatives
act
modulating
various
atherosclerosis‐mediating
risk
factors,
including
hyperlipidemia,
inflammation,
oxidative
stress,
malfunctioning
vascular
smooth
muscle
cells
(VSMCs).
Notably,
artesunate,
but
not
artemisinin,
attenuate
plasma
levels
TG,
TC,
VLDL‐C,
LDL‐c,
along
with
substantial
decline
arterial
lipid
deposition
through
enhancing
LDPL
activity
via
inducing
KFL2/NRF2/TCF7L2
axis.
found
to
ameliorate
inflammation
reducing
monocyte
adhesion
subsequent
transmigration
intima,
inhibiting
expression
ICAM‐1
VCAM‐1,
diminishing
NLRP3
inflammasome
activation,
inflammatory
factors
such
as
IL‐1β,
IL‐18,
TNF‐α,
MCP‐1,
TGF‐β1
mechanistically
mainly
suppressing
NF‐κB
activity.
could
exert
antioxidant
activating
PI3K/Akt/eNOS
signaling
pathway
ROS‐mediated
signal
pathway.
also
improve
VSMC
These
findings
suggest
new
therapeutic
agent
treating
atherosclerosis;
however,
future
clinical
trials
are
warranted
validate
efficiency
patients
atherosclerosis.
Язык: Английский
Artemisinin-loaded polylactic acid nanoparticles alleviate 1.2 N,N-dimethylhydrazine-induced colorectal cancer in Albino rats
Cancer Nanotechnology,
Год журнала:
2025,
Номер
16(1)
Опубликована: Апрель 19, 2025
Язык: Английский
Updating the Pharmacological Effects of α-Mangostin Compound and Unraveling Its Mechanism of Action: A Computational Study Review
Drug Design Development and Therapy,
Год журнала:
2024,
Номер
Volume 18, С. 4723 - 4748
Опубликована: Окт. 1, 2024
α-Mangostin,
initially
identified
in
1855,
is
a
xanthone
derivative
compound
predominantly
located
the
pericarp
of
mangosteen
fruit
(
Язык: Английский
Anti-tumor mechanism of artesunate
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 25, 2024
Artesunate
(ART)
is
a
classic
antimalarial
drug
with
high
efficiency,
low
toxicity
and
tolerance.
It
has
been
shown
to
be
safe
good
anti-tumor
effect.
Existing
clinical
studies
have
that
the
mechanisms
of
ART
mainly
include
inducing
apoptosis
autophagy
tumor
cells,
affecting
microenvironment,
regulating
immune
response,
overcoming
resistance,
as
well
inhibiting
cell
proliferation,
migration,
invasion,
angiogenesis.
proven
fight
against
lung
cancer,
hepatocarcinoma,
lymphoma,
multiple
myeloma,
leukemia,
colorectal
ovarian
cervical
malignant
melanoma,
oral
squamous
carcinoma,
bladder
prostate
cancer
other
neoplasms.
In
this
review,
we
highlight
effects
on
various
tumors
an
emphasis
its
mechanism,
which
helpful
propose
potential
research
directions
expand
application.
Язык: Английский