Adiponectin and HMW Oligomers in Relation to Inflammatory Markers in Crohn’s Disease Patients
Biomedicines,
Год журнала:
2025,
Номер
13(2), С. 273 - 273
Опубликована: Янв. 23, 2025
Background/Objectives:
Crohn's
disease
(CD),
a
chronic
inflammatory
gastrointestinal
illness,
is
the
result
of
genetics
and
environmental
factors.
Adipose
tissue
has
recently
been
found
to
play
significant
role
in
CD.
Methods:
here,
we
examined
relationship
between
adiponectin,
HMW
oligomers,
CD
92
patients.
Results:
first,
verified
that
patients'
therapies
had
no
influence
on
nutritional
biochemical
variables.
Correlation
analysis
adiponectin
parameters
relationship;
therefore,
investigated
its
with
severity
markers.
Based
divided
patients
into
tertiles
CDAI
was
lowest
second
third
tertile
[I:
<19.3
(n
=
31);
II:
19.3-22.2
III:
>22.2
30)].
Furthermore,
IL-6
CRP
were
higher
tertile,
while
lymphocytes
lower
tertile.
showed
both
oligomers
inversely
related
directly
CRP.
A
ROC
curve
evidenced
carrying
values
≤
19
performed
well
predicting
worse
lymphocyte
(AUCs:
0.826
0.806).
Next,
based
finding
highest
Lymphocytes
substantially
higher.
Conclusions:
altogether,
these
data
suggest
biological
for
status.
However,
molecular
effects
remain
unclear
further
studies
are
needed
clarify
applicability
as
biomarker.
Язык: Английский
Immune modulation for the patterns of epithelial cell death in inflammatory bowel disease
International Immunopharmacology,
Год журнала:
2025,
Номер
154, С. 114462 - 114462
Опубликована: Апрель 7, 2025
Язык: Английский
3'-Sialyllactose and B. infantis synergistically alleviate gut inflammation and barrier dysfunction by enriching cross-feeding bacteria for short-chain fatty acid biosynthesis
Gut Microbes,
Год журнала:
2025,
Номер
17(1)
Опубликована: Апрель 7, 2025
Ulcerative
colitis
(UC)
poses
significant
threats
to
human
health
and
quality
of
life
worldwide,
as
it
is
a
chronic
inflammatory
bowel
disease.
3'-sialyllactose
(3'-SL)
key
functional
component
milk
oligosaccharides.
This
study
systematically
evaluates
the
prebiotic
effects
3'-SL
its
therapeutic
potential
in
combination
with
Bifidobacterium
infantis
(B.
infantis)
for
UC.
The
findings
reveal
that
B.
synergistically
mitigate
intestinal
inflammation
barrier
dysfunction
by
promoting
production
short-chain
fatty
acids
(SCFAs)
through
cross-feeding
mechanisms
among
gut
microbiota.
Individually,
3'-SL,
infantis,
synbiotic
treatment
all
effectively
alleviated
UC
symptoms,
including
reduced
weight
loss,
improved
disease
activity
scores,
prevention
colon
shortening.
Histopathological
immunofluorescence
analyses
further
demonstrated
significantly
ameliorated
colonic
injury,
enhanced
function,
restored
goblet
cell
counts,
increased
glycoprotein
content
crypt
cells,
upregulated
expression
tight
junction
proteins
(ZO-1,
occludin,
claudin-1).
Notably,
outperformed
individual
components
better
restoring
microbiota
balance,
elevating
SCFA
levels,
modulating
serum
cytokine
profiles,
thereby
reducing
inflammation.
These
provide
mechanistic
insights
into
protective
underscore
other
disorders.
Язык: Английский
Identification of potential novel targets for treating inflammatory bowel disease using Mendelian randomization analysis
Ji‐Chang Fan,
Yuan Lü,
Jin‐Heng Gan
и другие.
International Journal of Colorectal Disease,
Год журнала:
2024,
Номер
39(1)
Опубликована: Окт. 16, 2024
Inflammatory
bowel
disease
(IBD)
is
a
complex
autoimmune
disorder,
although
some
medications
are
available
for
its
treatment.
However,
the
long-term
efficacy
of
these
drugs
remains
unsatisfactory.
Therefore,
there
need
to
develop
novel
drug
targets
IBD
Язык: Английский
Activation of PPARγ regulates M1/M2 macrophage polarization and attenuates dextran sulfate sodium salt‐induced inflammatory bowel disease via the STAT‐1/STAT‐6 pathway
The Kaohsiung Journal of Medical Sciences,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 30, 2024
This
study
aimed
to
investigate
whether
activation
of
PPARγ
regulates
M1/M2
macrophage
polarization
attenuate
dextran
sulfate
sodium
salt
(DSS)-induced
inflammatory
bowel
disease
(IBD)
via
the
STAT-1/STAT-6
pathway
in
vivo
and
vitro.
We
first
examined
effect
on
LPS/IFN-γ-treated
M1
RAW264.7
cells
IL-4/IL-13-treated
M2
cells.
Then,
40
male
C57BL/6
mice
were
randomly
divided
into
five
groups:
Sham,
IBD,
IBD
+
fludarabine
(FLU),
IL-4,
pioglitazone
(PI)
groups.
The
received
2.5%
DSS
their
drinking
water
for
7
days
then
regular
2
establish
experimental
murine
model.
FLU,
PI
groups
intraperitoneally
injected
with
PI,
respectively,
9
days.
Clinical
symptoms,
intestinal
barrier
function,
polarization,
PPARγ,
analyzed.
Activation
decreased
marker
expression
STAT-1
phosphorylation
increased
STAT-6
attenuated
such
as
weight
loss,
diarrhea,
bloody
stool.
Histological
analysis
revealed
that
treatment
reduced
cell
infiltration,
restored
mucosal
architecture,
improved
tight
junction
proteins.
Moreover,
iNOS
Arg-1,
Fizz
1,
Ym
1
by
inhibiting
promoting
DSS-induced
IBD.
Язык: Английский
Multi‐Omics Biomarkers for Predicting Efficacy of Biologic and Small‐Molecule Therapies in Adults With Inflammatory Bowel Disease: A Systematic Review
United European Gastroenterology Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 10, 2024
ABSTRACT
The
heterogeneity
and
suboptimal
efficacy
of
biological
treatments
small
molecule
drugs
necessitate
their
precise
selection
based
on
biomarkers
that
predict
therapeutic
responses
in
inflammatory
bowel
disease.
Recent
studies
have
identified
numerous
novel
predictive
to
biologics
modulators,
utilizing
a
variety
omics
approaches
In
this
review,
we
systematically
examine
baseline
therapies
drugs,
drawing
literature
from
PubMed.
Our
analysis
spans
multiple
disciplines,
including
genomics,
transcriptomics
(both
bulk
RNA
single‐cell
sequencing),
proteomics,
microbiomics,
metabolomics,
with
particular
emphasis
the
impact
models
integrating
datasets.
Additionally,
further
field
precision
medicine,
evaluated
specific
may
exhibit
distinct
effects
interventions.
Язык: Английский