Efficacy of botanicals and entomopathogenic fungi in controlling khapra beetle (Trogoderma granarium) infestations in stored wheat DOI Creative Commons

Ulas Khan,

Farid Asif Shaheen, Fahd A. Al‐Mekhlafi

и другие.

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, Год журнала: 2025, Номер 77(2)

Опубликована: Янв. 1, 2025

ABSTRACT The khapra beetle (Trogoderma granarium) is a notorious pest causing significant damage to stored grains, leading substantial economic losses globally. This study investigates the insecticidal efficacy of methanolic extracts derived from two indigenous plants, Cannabis sativa and Cymbopogon citratus, alongside entomopathogenic fungi, Beauveria bassiana Metarhizium anisopliae, against T. granarium. assesses mortality rates, weight loss in infected wheat seeds, adult emergence. Results revealed that higher concentrations extended exposure periods all significantly increased rates while simultaneously reducing seed C. at 25mg/mL achieved highest rate 78.92% ± 5% after 72 hours, with citratus showing 60.52% 2.43% under similar conditions. fungi extracts, particularly 108 spores/mL, demonstrated efficacy, B. M. anisopliae emergence 42.11% 1.92% 41.17% 1.92%, respectively. These findings highlight potential these as effective biopesticides for managing granarium infestations offering natural alternative chemical pesticides.

Язык: Английский

Exploration of natural products for the development of promising Cholinesterase inhibitors in Alzheimer’s disease treatment DOI Creative Commons
Hassan Nour, Oussama Abchır,

Nouh Mounadi

и другие.

Heliyon, Год журнала: 2025, Номер 11(4), С. e42479 - e42479

Опубликована: Фев. 1, 2025

Cholinesterase enzymes (BuChE and AChE) are privileged biological targets for the symptomatic treatment of Alzheimer's disease. Indeed, inhibition cholinesterase has been proven to improve neurotransmission mechanisms in disease patients. In this investigation, we attempt highlight new inhibitors from natural products. For purpose, secondary metabolites (299 phytoconstituents) twenty-eight Medicinal plants were virtually screened using molecular docking, pharmacokinetic toxicological analysis. Ten phytoconstituents (L82, L86, L92, L121, L148, L187, L211, L221, L228) exhibited their high binding affinity with BuChE, five phytoconstituents, namely L119, L147, L149, L192 L193, strong ability AChE. Subsequently, these evaluated ADMET properties. As result, L221 is predicted be highly bioavailable readily absorbed by human intestinal tract without significant toxicity concerns, making it suitable oral administration. Crucially, can penetrate blood-brain barrier (BBB), allowing effectively reach central nervous system. Molecular dynamics simulations MM-PBSA analysis revealed that best-screened phytoconstituent form thermodynamically favorable stable complex BuChE site. The conducted investigations highlighted promising outcomes orient towards rational development effective inhibitors.

Язык: Английский

Процитировано

2
Efficacy of botanicals and entomopathogenic fungi in controlling khapra beetle (Trogoderma granarium) infestations in stored wheat DOI Creative Commons

Ulas Khan,

Farid Asif Shaheen, Fahd A. Al‐Mekhlafi

и другие.

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, Год журнала: 2025, Номер 77(2)

Опубликована: Янв. 1, 2025

ABSTRACT The khapra beetle (Trogoderma granarium) is a notorious pest causing significant damage to stored grains, leading substantial economic losses globally. This study investigates the insecticidal efficacy of methanolic extracts derived from two indigenous plants, Cannabis sativa and Cymbopogon citratus, alongside entomopathogenic fungi, Beauveria bassiana Metarhizium anisopliae, against T. granarium. assesses mortality rates, weight loss in infected wheat seeds, adult emergence. Results revealed that higher concentrations extended exposure periods all significantly increased rates while simultaneously reducing seed C. at 25mg/mL achieved highest rate 78.92% ± 5% after 72 hours, with citratus showing 60.52% 2.43% under similar conditions. fungi extracts, particularly 108 spores/mL, demonstrated efficacy, B. M. anisopliae emergence 42.11% 1.92% 41.17% 1.92%, respectively. These findings highlight potential these as effective biopesticides for managing granarium infestations offering natural alternative chemical pesticides.

Язык: Английский

Процитировано

0