In-depth analysis of lupeol: delving into the diverse pharmacological profile

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Ноя. 13, 2024

Lupeol, a naturally occurring lupane-type pentacyclic triterpenoid, is widely distributed in various edible vegetables, fruits, and medicinal plants. Notably, it found high concentrations plants like Tamarindus indica , Allanblackia monticola Emblica officinalis among others. Quantitative studies have highlighted its presence Elm bark, Olive fruit, Aloe leaf, Ginseng oil, Mango pulp, Japanese Pear bark. This compound synthesized from squalene through the mevalonate pathway can also be synthetically produced lab, addressing challenges natural product synthesis. Over past four decades, extensive research has demonstrated lupeol’s multifaceted pharmacological properties, including anti-inflammatory, antioxidant, anticancer, antibacterial effects. Despite significant therapeutic potential, clinical applications of lupeol been limited by poor water solubility bioavailability. Recent advancements focused on nano-based delivery systems to enhance bioavailability, development derivatives further amplified bioactivity. review provides comprehensive overview latest understanding benefits lupeol. It discusses innovative strategies improve thereby enhancing efficacy. The aim consolidate current knowledge stimulate into potential derivatives.

Язык: Английский

Thiazolidinedione-Conjugated Lupeol Derivatives as Potent Anticancer Agents Through a Mitochondria-Mediated Apoptotic Pathway

Molecules, Год журнала: 2024, Номер 29(20), С. 4957 - 4957

Опубликована: Окт. 20, 2024

To improve the potential of lupeol against cancer cells, a privileged structure, thiazolidinedione, was introduced into its C-3 hydroxy group with ester, piperazine-carbamate, or ethylenediamine as linker, and three series thiazolidinedione-conjugated compounds (

Язык: Английский

Synthesis and Anticancer Activity of Ergosterol Peroxide 3-Carbamate Pyrazole Side-Chain Derivatives

Russian Journal of General Chemistry, Год журнала: 2024, Номер 94(12), С. 3348 - 3362

Опубликована: Дек. 1, 2024

Язык: Английский