Targeting protein aggregation using a cocoa-bean shell extract to reduce α-synuclein toxicity in models of Parkinson’s disease DOI Creative Commons
Farida Tripodi, Alessia Lambiase, Hind Moukham

и другие.

Current Research in Food Science, Год журнала: 2024, Номер 9, С. 100888 - 100888

Опубликована: Янв. 1, 2024

Neurodegenerative diseases are among the major challenges in modern medicine, due to progressive aging of world population. Among these, Parkinson's disease (PD) affects 10 million people worldwide and is associated with aggregation presynaptic protein α-synuclein (α-syn). Here we use two different PD models, yeast cells neuroblastoma overexpressing α-syn, investigate protective effect an extract from cocoa shell, which a by-product roasting process beans. The LC-ESI-qTOF-MS NMR analyses allow identification amino acids (including essential ones), organic acids, lactate glycerol, confirming also presence methylxanthines, namely caffeine theobromine. present study demonstrates that supplementation bean shell (CBSE) strongly improves longevity expressing reducing level reactive oxygen species, activating autophagy intracellular aggresomes. These anti-aggregation properties confirmed cells, where CBSE treatment leads activation AMPK kinase significant reduction toxic α-syn oligomers. Results obtained by surface plasmon resonance (SPR) assay highlights binds concentration-dependent manner, supporting its inhibitory role on amyloid α-syn. findings suggest form nutraceuticals may represent promising way prevent neurodegenerative aggregation.

Язык: Английский

Characterization of Walnut Oil and Evaluation of Its Neuroprotective Effects in an In Vitro Model of Parkinson’s Disease DOI Creative Commons
Monica Filaferro, Rossella Avallone, Cecilia Rustichelli

и другие.

Molecules, Год журнала: 2024, Номер 29(23), С. 5718 - 5718

Опубликована: Дек. 4, 2024

Parkinson's disease (PD) is a common neurodegenerative disorder marked by the degeneration of dopaminergic neurons and buildup α-synuclein aggregates. The current treatments focus on symptom relief, with no drugs available to halt progression. This has prompted interest in plant-based extracts as alternative therapies. study examines neuroprotective antioxidant effects walnut oil (WO), extracted from

Язык: Английский

Процитировано

1
Targeting protein aggregation using a cocoa-bean shell extract to reduce α-synuclein toxicity in models of Parkinson’s disease DOI Creative Commons
Farida Tripodi, Alessia Lambiase, Hind Moukham

и другие.

Current Research in Food Science, Год журнала: 2024, Номер 9, С. 100888 - 100888

Опубликована: Янв. 1, 2024

Neurodegenerative diseases are among the major challenges in modern medicine, due to progressive aging of world population. Among these, Parkinson's disease (PD) affects 10 million people worldwide and is associated with aggregation presynaptic protein α-synuclein (α-syn). Here we use two different PD models, yeast cells neuroblastoma overexpressing α-syn, investigate protective effect an extract from cocoa shell, which a by-product roasting process beans. The LC-ESI-qTOF-MS NMR analyses allow identification amino acids (including essential ones), organic acids, lactate glycerol, confirming also presence methylxanthines, namely caffeine theobromine. present study demonstrates that supplementation bean shell (CBSE) strongly improves longevity expressing reducing level reactive oxygen species, activating autophagy intracellular aggresomes. These anti-aggregation properties confirmed cells, where CBSE treatment leads activation AMPK kinase significant reduction toxic α-syn oligomers. Results obtained by surface plasmon resonance (SPR) assay highlights binds concentration-dependent manner, supporting its inhibitory role on amyloid α-syn. findings suggest form nutraceuticals may represent promising way prevent neurodegenerative aggregation.

Язык: Английский

Процитировано

0