Assessment of the Anti-inflammatory Effects of Several Native Macrolichens on Carrageenan-Induced Paw Edema in Rats DOI Open Access

Sajedeh Narimani Zamanabadi,

Ali Asghar Hemmati,

Roya Zalaghi

и другие.

Jundishapur Journal of Natural Pharmaceutical Products, Год журнала: 2025, Номер 20(2)

Опубликована: Март 28, 2025

Background: Inflammation is a natural defense mechanism, but it also plays role in many chronic diseases such as diabetes, obesity, and cancer. While drugs like indomethacin are commonly used to reduce inflammation, their long-term use can lead side effects. Lichens, organisms, contain bioactive compounds that may inflammation while minimizing Objectives: To assess the anti-inflammatory effects of lichen extracts at different doses compare efficacy with reducing carrageenan-induced rat model. Methods: A total 30 male albino Wistar rats, each weighing between 200 - 250 g, were randomly assigned into five groups six animals. Groups 1 3 administered test extract 20, 40, 80 mg/kg, respectively. Group 4 served positive control received 10 group 5, negative control, an equivalent volume normal saline (vehicle). All treatments prior induction inflammation. was elicited via intraplantar injection 100 µL 1% (w/v) carrageenan solution prepared 0.9% saline. We measured paw volumes using plethysmometer baseline (time zero) again 1, 2, 3, 4, 5 hours after injection. Changes relative recorded evaluate treatments. Results: The study demonstrated increasing significantly reduced swelling, particularly mg/kg dosage. However, not strong indomethacin. Still, could be safer option for because likely causes fewer than synthetic drugs. Conclusions: Lichen have good potential alternative More research needed explore higher doses, understand how work, improve formulations make them more effective.

Язык: Английский

Chemical Profiling and In Vitro Evaluation of Bioactive Properties of Evernia prunastri Extract: Implications for Therapeutic Applications DOI Creative Commons
Dejan Stojković, Jelena Živković, Stefani Bolevich

и другие.

Plants, Год журнала: 2025, Номер 14(4), С. 583 - 583

Опубликована: Фев. 14, 2025

Evernia prunastri (L.) Ach. (Parmeliaceae), an edible lichen commonly known as oakmoss, was traditionally used by Egyptians to make bread. In this study, the ethyl-acetate (EtOAc) extract of E. investigated for its potential therapeutic applications in diabetes mellitus, Alzheimer's and Parkinson's diseases, oxidative stress, bacterial infections. The exhibited significant vitro enzyme inhibition activities, including anti-amylase anti-glucosidase activities linked anti-cholinesterase anti-tyrosinase associated with diseases. antioxidant activity evaluated through multiple assays, free radical scavenging (DPPH ABTS), reducing power (CUPRAC FRAP), metal chelation, phosphomolybdenum methods, demonstrating strong stress relief potential. antibacterial properties were also confirmed testing, showing efficacy against a range strains. Total phenolic flavonoid contents quantified, while chemical profile EtOAc determined LC-HRMS/MS analysis. composition predominantly characterized depsides (evernic acid atranorin), acids (orsellinic acid), dibenzofurans, revealing diverse array bioactive secondary metabolites. demonstrated broad spectrum biological inhibition, effects, properties. This study highlights functional food, providing rich source compounds numerous health-promoting it suggests relevance chronic diseases such diabetes, Alzheimer's,

Язык: Английский

Процитировано

0
Assessment of the Anti-inflammatory Effects of Several Native Macrolichens on Carrageenan-Induced Paw Edema in Rats DOI Open Access

Sajedeh Narimani Zamanabadi,

Ali Asghar Hemmati,

Roya Zalaghi

и другие.

Jundishapur Journal of Natural Pharmaceutical Products, Год журнала: 2025, Номер 20(2)

Опубликована: Март 28, 2025

Background: Inflammation is a natural defense mechanism, but it also plays role in many chronic diseases such as diabetes, obesity, and cancer. While drugs like indomethacin are commonly used to reduce inflammation, their long-term use can lead side effects. Lichens, organisms, contain bioactive compounds that may inflammation while minimizing Objectives: To assess the anti-inflammatory effects of lichen extracts at different doses compare efficacy with reducing carrageenan-induced rat model. Methods: A total 30 male albino Wistar rats, each weighing between 200 - 250 g, were randomly assigned into five groups six animals. Groups 1 3 administered test extract 20, 40, 80 mg/kg, respectively. Group 4 served positive control received 10 group 5, negative control, an equivalent volume normal saline (vehicle). All treatments prior induction inflammation. was elicited via intraplantar injection 100 µL 1% (w/v) carrageenan solution prepared 0.9% saline. We measured paw volumes using plethysmometer baseline (time zero) again 1, 2, 3, 4, 5 hours after injection. Changes relative recorded evaluate treatments. Results: The study demonstrated increasing significantly reduced swelling, particularly mg/kg dosage. However, not strong indomethacin. Still, could be safer option for because likely causes fewer than synthetic drugs. Conclusions: Lichen have good potential alternative More research needed explore higher doses, understand how work, improve formulations make them more effective.

Язык: Английский

Процитировано

0