Therapeutic efficacy of plant-based hydrogels in burn wound healing: focus on Satureja montana L. and Origanum vulgare L DOI Creative Commons
Grigory Demyashkin, Mikhail Parshenkov,

Alibek Tokov

и другие.

SCRIPTA MEDICA, Год журнала: 2025, Номер 56(1), С. 27 - 35

Опубликована: Янв. 1, 2025

Background/Aim: Burn injuries present a critical issue for healthcare systems worldwide. They often lead to numerous complications, including persistent inflammation, impaired healing and heightened infection risks. The growing challenge of antibiotic resistance further complicates treatment, making bacterial infections harder control wound less effective. Existing treatment methods are limited, highlighting the need alternative approaches. Aim this study was analyse influence hydrolate-based gels derived from Satureja montana L. Origanum vulgare on burn wounds. Methods: New Zealand white rabbits (n = 25) with standardised Grade IIIa thermal burns were assigned groups receiving (Satureja or L.), conventional therapy (Betadine (povidone-iodine) Levomecol (methyluracil, chloramphenicol)), no treatment. Inflammatory responses tracked by collecting blood samples at study's begin, day 3 oneand two-weeks post-burn, subsequent ELISA analysis. Histological evaluation tissue regeneration inflammatory response conducted using haematoxylin eosin staining days 3, 7 14. Results: By 14, demonstrated most effective reduction in interleukin 6 (IL-6), tumour necrosis factor alpha (TNF-a) C-reactive protein (CRP) levels, nearing baseline values. This biochemical improvement correlated histological findings, showing advanced epithelial regeneration, reduced cell infiltration clearer dermal-epidermal boundaries. results highlight as both inflammation repair compared therapy. Conclusion: Hydrolate-based represent promising option adjunctive group significant improvements while showed comparable standard

Язык: Английский

The Role of Elderberry Hydrolate as a Therapeutic Agent in Palliative Care DOI Creative Commons
Sara Gonçalves, Ana Caramelo

Antioxidants, Год журнала: 2025, Номер 14(2), С. 233 - 233

Опубликована: Фев. 18, 2025

Elderberry hydrolate, derived from the berries of Sambucus nigra, has gained attention for its therapeutic properties, particularly in skincare. This review explores potential applications palliative care, where patients often experience compromised skin health due to illness or treatment. The bioactive compounds elderberry including phenylacetaldehyde, 2-acetyl-pyrrole, n-hexanal, furfural, and (E)-beta-damascenone, contribute anti-inflammatory, antioxidant, antimicrobial, skin-healing effects. These properties make it a promising option addressing common dermatological issues such as irritation, dryness, pruritus, inflammation. For example, phenylacetaldehyde's antimicrobial anti-inflammatory actions help soothe irritated skin, while 2-acetyl-pyrrole's antioxidant effects protect sensitive oxidative stress. Additionally, n-hexanal's reduce infection risks furfural aids regeneration. (E)-beta-damascenone's maintain prevent further damage. Despite these effects, barriers widespread implementation hydrolate care exist, cost, accessibility, patient sensitivities, regulatory challenges. Future research focusing on standardized chemical profiling, clinical trials, practical concerns will be crucial integrating into regimens. highlights natural, supportive therapy enhancing comfort quality life settings.

Язык: Английский

Процитировано

0

A comprehensive review on progression and innovations in microwave assisted extraction technology for essential oils DOI Open Access
Irsha Dhotre

Journal of Chemical Technology & Biotechnology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 22, 2025

Abstract This Review Paper provides a comprehensive analysis of extraction methods for essential oils, focusing particularly on the innovative Microwave Assisted Extraction (MAE) technology. Essential derived from various plant parts, are highly valued their aromatic and therapeutic properties, finding applications in industries such as perfumery, aromatherapy, cosmetics, food flavoring. Traditional often face challenges, including prolonged times, excessive solvent usage, risk degrading sensitive compounds. In contrast, MAE has emerged superior alternative, offering significant advantages expedited processes, reduced consumption, enhanced preservation volatile study highlights key findings, optimal parameters MAE, microwave power, time, solvent‐to‐raw material ratios, which collectively influence yield quality oils. Notably, findings this survey, indicates that can achieve up to 40% increase oil compared conventional methods. The review also discusses evolution techniques, initial simple heating advanced systems incorporating infrared temperature sensors magnetic stirrers, improve precision efficiency. By elucidating these advancements, paper underscores transformative impact paving way future research development field. © 2025 Society Chemical Industry (SCI).

Язык: Английский

Процитировано

0

Therapeutic efficacy of plant-based hydrogels in burn wound healing: focus on Satureja montana L. and Origanum vulgare L DOI Creative Commons
Grigory Demyashkin, Mikhail Parshenkov,

Alibek Tokov

и другие.

SCRIPTA MEDICA, Год журнала: 2025, Номер 56(1), С. 27 - 35

Опубликована: Янв. 1, 2025

Background/Aim: Burn injuries present a critical issue for healthcare systems worldwide. They often lead to numerous complications, including persistent inflammation, impaired healing and heightened infection risks. The growing challenge of antibiotic resistance further complicates treatment, making bacterial infections harder control wound less effective. Existing treatment methods are limited, highlighting the need alternative approaches. Aim this study was analyse influence hydrolate-based gels derived from Satureja montana L. Origanum vulgare on burn wounds. Methods: New Zealand white rabbits (n = 25) with standardised Grade IIIa thermal burns were assigned groups receiving (Satureja or L.), conventional therapy (Betadine (povidone-iodine) Levomecol (methyluracil, chloramphenicol)), no treatment. Inflammatory responses tracked by collecting blood samples at study's begin, day 3 oneand two-weeks post-burn, subsequent ELISA analysis. Histological evaluation tissue regeneration inflammatory response conducted using haematoxylin eosin staining days 3, 7 14. Results: By 14, demonstrated most effective reduction in interleukin 6 (IL-6), tumour necrosis factor alpha (TNF-a) C-reactive protein (CRP) levels, nearing baseline values. This biochemical improvement correlated histological findings, showing advanced epithelial regeneration, reduced cell infiltration clearer dermal-epidermal boundaries. results highlight as both inflammation repair compared therapy. Conclusion: Hydrolate-based represent promising option adjunctive group significant improvements while showed comparable standard

Язык: Английский

Процитировано

0