Exploring NUP62’s role in cancer progression, tumor immunity, and treatment response: insights from multi-omics analysis DOI Creative Commons
Lihong Chen, Youfu He,

Menghui Duan

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 3, 2025

Background NUP62, a key component of the nuclear pore complex, is closely associated with cellular functions and cancer progression. However, its expression patterns, prognostic value, relationship tumour immunity drug sensitivity across multiple cancers have not been systematically studied. This study used multi-omics analyses combined experimental validation in gastric to investigate expression, functional characteristics, clinical relevance NUP62 cancer. Methods Data from TCGA, GTEx, CPTAC databases were analyse mutation associations NUP62. Tools such as SangerBox, TIMER 2.0, GSEA employed evaluate between immune microenvironment, well involvement signalling pathways. Immunohistochemistry RT-PCR validate tissues. PRISM CTRP utilised assess correlation sensitivity. Results was significantly upregulated poor prognosis clear cell renal carcinoma (KIRC), lower-grade glioma (LGG), adrenocortical (ACC), while playing protective role others, bladder (BLCA) stomach (STAD). Functional showed that involved cycle regulation, DNA damage repair, immunity. High correlated increased infiltration cells, macrophages T higher response rate immunotherapy. Drug analysis identified marker various chemotherapeutic agents. Validation experiments demonstrated mRNA protein levels tissues than adjacent normal Conclusions plays critical shows potential biomarker for diagnosis, prognosis, therapeutic prediction. Its pathways highlights target immunotherapy precision medicine.

Язык: Английский

Strategies for the Viral Exploitation of Nuclear Pore Transport Pathways DOI Creative Commons
Xin Zhang, Keesiang Lim,

Yujia Qiu

и другие.

Viruses, Год журнала: 2025, Номер 17(2), С. 151 - 151

Опубликована: Янв. 23, 2025

Viruses frequently exploit the host’s nucleocytoplasmic trafficking machinery to facilitate their replication and evade immune defenses. By encoding specialized proteins other components, they strategically target host nuclear transport receptors (NTRs) nucleoporins within spiderweb-like inner channel of pore complex (NPC), enabling efficient access nucleus. This review explores intricate mechanisms governing import export viral with a focus on interplay between factors determinants that are essential for these processes. Given pivotal role shuttling in life cycle, we also examine therapeutic strategies aimed at disrupting pathways. includes evaluating efficacy pharmacological inhibitors impairing assessing potential as antiviral treatments. Furthermore, emphasize need continued research develop targeted therapies leverage vulnerabilities trafficking. Emerging high-resolution techniques, such advanced imaging computational modeling, transforming our understanding dynamic interactions viruses NPC. These cutting-edge tools driving progress identifying novel opportunities uncovering deeper insights into pathogenesis. highlights importance advancements paving way innovative strategies.

Язык: Английский

Процитировано

0
Exploring NUP62’s role in cancer progression, tumor immunity, and treatment response: insights from multi-omics analysis DOI Creative Commons
Lihong Chen, Youfu He,

Menghui Duan

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 3, 2025

Background NUP62, a key component of the nuclear pore complex, is closely associated with cellular functions and cancer progression. However, its expression patterns, prognostic value, relationship tumour immunity drug sensitivity across multiple cancers have not been systematically studied. This study used multi-omics analyses combined experimental validation in gastric to investigate expression, functional characteristics, clinical relevance NUP62 cancer. Methods Data from TCGA, GTEx, CPTAC databases were analyse mutation associations NUP62. Tools such as SangerBox, TIMER 2.0, GSEA employed evaluate between immune microenvironment, well involvement signalling pathways. Immunohistochemistry RT-PCR validate tissues. PRISM CTRP utilised assess correlation sensitivity. Results was significantly upregulated poor prognosis clear cell renal carcinoma (KIRC), lower-grade glioma (LGG), adrenocortical (ACC), while playing protective role others, bladder (BLCA) stomach (STAD). Functional showed that involved cycle regulation, DNA damage repair, immunity. High correlated increased infiltration cells, macrophages T higher response rate immunotherapy. Drug analysis identified marker various chemotherapeutic agents. Validation experiments demonstrated mRNA protein levels tissues than adjacent normal Conclusions plays critical shows potential biomarker for diagnosis, prognosis, therapeutic prediction. Its pathways highlights target immunotherapy precision medicine.

Язык: Английский

Процитировано

0