Inflammation-driven biomimetic nano-polyphenol drug delivery system alleviates severe acute pancreatitis by inhibiting macrophage PANoptosis and pancreatic enzymes oversecretion DOI Creative Commons
Junyong Wu, Hai Huang, W. Xu

и другие.

Journal of Advanced Research, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Severe acute pancreatitis (SAP) is a critical inflammatory disease with high morbidity and mortality. Current treatments focused on symptomatic relief but failed to prevent inflammation progression in cellular level. In order develop an SAP-targeting drug delivery system alleviate SAP level illustrate its mechanism, we explored the use of proanthocyanidin (PYD) pentoxifylline (PTX) loaded into macrophage membrane-coated self-assembly nanoparticles (FePTX@CM NPs) for targeted treatment. The combination application these two drugs was innovative aid. We developed NPs by strategy cell membrane coating. Its particle size zeta potential were measured dynamic light scatter (DLS). morphology observed transmission electron microscopy (TEM). And encapsulation efficiency evaluated nano-flow cytometry. total protein profile determined via Coomassie brilliant blue. explore mechanism our against animal levels. Bioinformatics approaches, TEM, immunofluorescent assay co-immunoprecipitation performed comprehensively explain specific anti-SAP FePTX@CM NPs. After inflammation-driven targeting, PYD inhibited pancreatic amylase lipase release suppressing mitochondrial reactive oxygen species (mtROS)/Golgi stress, while PTX prevented SAP-associated PANoptosis inhibiting Zbp1 signal pathway. protection effect biomimetic worked from different aspects symptoms relative cells. demonstrated effective pancreas reduced systemic especially pro-inflammatory recruitment activation, minimized tissue damage mouse models, offering promising therapeutic clinical management.

Язык: Английский

Effect of Antioxidants on the Gut Microbiome Profile and Brain Functions: A Review of Randomized Controlled Trial Studies DOI Creative Commons
Aleksandra Hyży, Hanna Rozenek, Ewa Gondek

и другие.

Foods, Год журнала: 2025, Номер 14(2), С. 176 - 176

Опубликована: Янв. 8, 2025

Antioxidants are widely recognized for their potential health benefits, including impact on cognitive function and gut microbiome modulation. Understanding these effects is essential exploring broader clinical applications. This review aims to evaluate the of antioxidants function, with a focus findings from randomized controlled trials (RCTs). The studies involved human participants across range age groups, interventions encompassing natural antioxidant sources, such as berries, well specific vitamins. An extensive search PubMed, SCOPUS, Web Science databases identified six relevant RCTs, each evaluated bias. These focused variety antioxidant-rich products, both naturally derived sources supplemental forms. Antioxidants, vitamins C, B2, D, along polyphenols xanthohumol, fermented papaya, peanuts, berry extracts, demonstrate support promote through mechanisms that modulate diversity reduce inflammation. However, observed changes in were modest inconsistent studies. While preliminary evidence suggests may benefit heterogeneity existing limits immediate applicability. Additionally, more robust RCTs needed substantiate guide future interventions.

Язык: Английский

Процитировано

2
Inflammation-driven biomimetic nano-polyphenol drug delivery system alleviates severe acute pancreatitis by inhibiting macrophage PANoptosis and pancreatic enzymes oversecretion DOI Creative Commons
Junyong Wu, Hai Huang, W. Xu

и другие.

Journal of Advanced Research, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Severe acute pancreatitis (SAP) is a critical inflammatory disease with high morbidity and mortality. Current treatments focused on symptomatic relief but failed to prevent inflammation progression in cellular level. In order develop an SAP-targeting drug delivery system alleviate SAP level illustrate its mechanism, we explored the use of proanthocyanidin (PYD) pentoxifylline (PTX) loaded into macrophage membrane-coated self-assembly nanoparticles (FePTX@CM NPs) for targeted treatment. The combination application these two drugs was innovative aid. We developed NPs by strategy cell membrane coating. Its particle size zeta potential were measured dynamic light scatter (DLS). morphology observed transmission electron microscopy (TEM). And encapsulation efficiency evaluated nano-flow cytometry. total protein profile determined via Coomassie brilliant blue. explore mechanism our against animal levels. Bioinformatics approaches, TEM, immunofluorescent assay co-immunoprecipitation performed comprehensively explain specific anti-SAP FePTX@CM NPs. After inflammation-driven targeting, PYD inhibited pancreatic amylase lipase release suppressing mitochondrial reactive oxygen species (mtROS)/Golgi stress, while PTX prevented SAP-associated PANoptosis inhibiting Zbp1 signal pathway. protection effect biomimetic worked from different aspects symptoms relative cells. demonstrated effective pancreas reduced systemic especially pro-inflammatory recruitment activation, minimized tissue damage mouse models, offering promising therapeutic clinical management.

Язык: Английский

Процитировано

0